Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Pumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress.
Animal Study Chronic Stress Depression Pumpkin Seed
The researchers used forty male albino rats, split into four different groups: a negative control group, a chronic unpredictable mild stress (CUMS) group, a fluoxetine-treated group, and a pumpkin-treated group. These rats were exposed to CUMS for 28 days, with the treatments applied during the last 14 days of this exposure period. After these 28 days, the scientists evaluated the behavioral, biochemical, and histopathological alterations in these rats.
The application of pumpkin extract significantly reduced markers of stress and inflammation, while increasing antioxidant levels. Additionally, the extract helped reduce structural damage in the hippocampal region of the brain caused by exposure to CUMS. These effects were comparable to those observed by administering fluoxetine, a conventional antidepressant.
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Acupuncture in postpartum depression was at least as effective as fluoxetine hydrochloride, supporting the notion that acupuncture may be a safe and effective option.
Systematic Review Pregnancy
Of the 1592 studies reviewed, three met the inclusion criteria for quantitative analysis. Two studies reported no significant differences between acupuncture and fluoxetine for depression, while the third reported significant improvements.
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Clinical Trials
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Study Protocols
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Presentation Slides
Chinese Medicine Research Hub
Animal Study
Pumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress.
2021 Oxidative Medicine and Cellular Longevity L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus
Ayuob N, Shaker SA, Hawuit E, Al-Abbas N, Shaer NA, Al Jaouni S, Mahdi MR
Chinese Medicine Research Hub
Systematic Review
Acupuncture in postpartum depression was at least as effective as fluoxetine hydrochloride, supporting the notion that acupuncture may be a safe and effective option.
2018 British Journal of Midwifery Acupuncture versus antidepressants in the management of postpartum depression: A systematic review
Akari Komori, David Arthur, Samara Radford, Hsiewe Ying Tan, Li Zheng, Mira An, Rika Umeda, and Zhen Zheng
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Fluoxetine" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Fluoxetine" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Fluoxetine" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Animal Study published in 2021 in the journal Oxidative Medicine and Cellular Longevity found that Pumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress. The researchers used forty male albino rats, split into four different groups: a negative control group, a chronic unpredictable mild stress (CUMS) group, a fluoxetine-treated group, and a pumpkin-treated group. These rats were exposed to CUMS for 28 days, with the treatments applied during the last 14 days of this exposure period. After these 28 days, the scientists evaluated the behavioral, biochemical, and histopathological alterations in these rats.
The application of pumpkin extract significantly reduced markers of stress and inflammation, while increasing antioxidant levels. Additionally, the extract helped reduce structural damage in the hippocampal region of the brain caused by exposure to CUMS. These effects were comparable to those observed by administering fluoxetine, a conventional antidepressant.
A Systematic Review published in 2018 in the journal British Journal of Midwifery found that Acupuncture in postpartum depression was at least as effective as fluoxetine hydrochloride, supporting the notion that acupuncture may be a safe and effective option. Of the 1592 studies reviewed, three met the inclusion criteria for quantitative analysis. Two studies reported no significant differences between acupuncture and fluoxetine for depression, while the third reported significant improvements.