Bone Formation

Presentation Slides

Chinese Medicine Research Hub

Experimental Study

Chrysanthemum coronarium L. extract can both stimulate bone building cells and inhibit bone breaking cells, so has potential as a natural treatment for osteoporosis.

2020 Evidence-Based Complementary and Alternative Medicine Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo
Kim SA, Lee AS, Hur HJ, Lee SH, Sung MJ

Chinese Medicine Research Hub

Review Article

Catechins in green tea potentially counteract osteoporosis by negatively affecting bone loss processes and enhancing bone formation processes.

2020 Antioxidants Osteoprotective Roles of Green Tea Catechins
Huang HT, Cheng TL, Lin SY, Ho CJ, Chyu JY, Yang RS, Chen CH, Shen CL

Chinese Medicine Research Hub

Review Article

Cherries and their products have antioxidant properties, the capacity to inhibit the acute inflammatory response to urate crystals, and the ability to decrease bone resorption that is characteristic of gouty bone erosions.

2019 Therapeutic Advances in Musculoskeletal Disease Is there a role for cherries in the management of gout?
Collins MW, Saag KG, Singh JA

Chinese Medicine Research Hub

Review Article

Dried plums, or prunes, have potential to exert beneficial effects on bone health and may help in combating osteoporosis in postmenopausal women, if consumed as part of their recommended fruit intake.

2017 Nutrients Dried Plums, Prunes and Bone Health: A Comprehensive Review
Wallace T

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Bone Formation" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Bone Formation" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Bone Formation" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Experimental Study published in 2020 in the journal Evidence-Based Complementary and Alternative Medicine found that Chrysanthemum coronarium L. extract can both stimulate bone building cells and inhibit bone breaking cells, so has potential as a natural treatment for osteoporosis. The study examined the effects of Chrysanthemum coronarium L. extracts on in vitro cell cultures and animal models with bone loss. This was done by observing the increase and decrease of bone formation markers in different cell lines, specifically the murine preosteoblastic cell line MC3T3-E1, and the murine macrophage-like cell line RAW264.7 respectively. The results showed that the extract stimulated the differentiation of osteoblasts, cells responsible for bone formation, and inhibited osteoclast differentiation, cells that break down bone. In osteoporotic animal models, the extract prevented bone loss, preserved the structure of the small bones and improved serum bone turnover markers. This implies that the extract has promising potential as a natural therapy for osteoporotic bone loss.

A Review Article published in 2020 in the journal Antioxidants found that Catechins in green tea potentially counteract osteoporosis by negatively affecting bone loss processes and enhancing bone formation processes. The research paper explores the role of catechins, a key compound found in green tea, in combating osteoporosis. In an endeavour to understand the cellular processes, the research focuses on the two critical processes involved in the onset of osteoporosis: osteoblastogenesis, the process of bone formation, and osteoclastogenesis, the process of bone resorption. Specifically, the research emphasizes that inflammation and high reactive oxygen levels enhance osteoclastogenesis while concurrently reducing osteoblastogenesis. Green tea catechins, which have strong antioxidant and anti-inflammatory properties, are assumed to rebalance these two processes. The discussions revolve around the potential of green tea catechins to curb osteoclastogenesis by increasing the rate of osteoclast apoptosis, hampering osteoclastogenesis, and impeding bone resorption in a controlled environment. This is achieved directly through interactions with pre-osteoclasts/osteoclasts or indirectly through regulation of pre-osteoclasts via mesenchymal stem cells (MSCs) or stromal cells. Furthermore, catechins are credited with boosting osteoblastogenesis by enhancing the osteogenic differentiation of MSCs and improving osteoblastic survival, proliferation, differentiation, and mineralization. The paper verifies the positive in-vitro effects of catechins on osteogenesis through various animal models and human observational studies.

A Review Article published in 2019 in the journal Therapeutic Advances in Musculoskeletal Disease found that Cherries and their products have antioxidant properties, the capacity to inhibit the acute inflammatory response to urate crystals, and the ability to decrease bone resorption that is characteristic of gouty bone erosions. Phenolics, and more specifically, the anthocyanins found abundantly in cherries, have been linked to the inhibition of IL-6, TNF-α, IL-1β, IL-8, COX-I and COX-II, as well as the downregulation of NFkB-mediated osteoclastogenesis, suggesting that cherries may have the ability to reduce both acute and chronic inflammation that play a role in recurrent gout flares and chronic destructive arthropathy. Additionally, cyanidin-3-glucoside enhanced genes related to osteoblast differentiation, suggesting that anthocyanins may also play a role in bone formation.

A Review Article published in 2017 in the journal Nutrients found that Dried plums, or prunes, have potential to exert beneficial effects on bone health and may help in combating osteoporosis in postmenopausal women, if consumed as part of their recommended fruit intake. The research process involved a comprehensive review of scientific literature available in the PubMed database up until January 24, 2017. This literature included cell studies, animal studies, population and clinical studies that examined effects of dried plums or their extracts on markers of bone health. In total, 24 research papers were reviewed and their findings are summarized. Discussing the results, animal, cell, and clinical studies suggest that dried plums or their extracts positively impact bone formation and limit bone breakdown. This is likely due to the influence of dried plums on cell signaling pathways that dictate osteoblast (bone-building cells) and osteoclast (bone-destroying cells) differentiation. Clinical studies also indicate that consumption of dried plums could have beneficial effects on bone mineral density, particularly in postmenopausal women. There were no adverse effects reported in these studies, further suggesting that they could safely be included in regular dietary routines.

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