Premature ovarian failure (POF)
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Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure
2022 Nov 26 Evidence-Based Complementary and Alternative Medicine Li M, Xiao YB, Wei L, Liu Q, Liu PY, Yao JF
Studies had shown that TCM prescription had therapeutic benefits by inhibiting apoptosis, slowing the aging process, promoting angiogenesis, and improving immunity to treat premature ovarian failure (POF).
Review Article
A Network Pharmacology Study on the Similarities and Differences in the Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of Premature Ovarian Failure
2022 Oct 18 Combinatorial Chemistry & High Throughput Screening Shanshan Mei, Chaoqin Yu, Jie Ding, Wen Cheng
Network Pharmacology Ovarian InsufficiencyThe Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
Current Research on Complementary and Alternative Medicine in the Treatment of Premature Ovarian Failure: An Update Review
2022 Jun 23 Evidence-Based Complementary and Alternative Medicine Li Y, Yan MY, Chen QC, Xie YY, Li CY, Han FJ
In recent years, clinical and scientific researchers have paid more attention to POF and its associated symptoms such as amenorrhea and infertility. As the research has progressed, more and more CAM therapies have become widely accepted and well used, including herbal medicine, acupuncture, psychology, exercise, vitamins, massage, diet, etc. These therapies can significantly improve the patient's symptoms and hormone levels and can be used in combination with other treatments to enhance their efficacy.
Review Article Complementary Medicine
Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure
2021 Nov Journal of Ethnopharmacology Zhou F, Song Y, Liu X, Zhang C, Li F, Hu R, et al.
Our findings indicated that Si-Wu-Tang (SWT) protected ovarian function of Cy-induced premature ovarian failure (POF) mice by improving the antioxidant ability and promoting ovarian angiogenesis, thereby providing scientific evidence for the treatment of POF using SWT.
Network Pharmacology Si Wu TangThe Treatment of Complementary and Alternative Medicine on Premature Ovarian Failure
2021 Apr 15 Evidence-Based Complementary and Alternative Medicine Lin J, Wu D, Jia L, Liang M, Liu S, Qin Z, et al.
In conclusion, although the effectiveness of herbal therapy and acupuncture therapy has been well documented, it is difficult to make definitive recommendations for clinical guidance. Most of these studies are hindered by a small sample size or limited to one ethnic group, and there are few studies on adverse reactions, so it is not clear whether the effects of these treatments span all ethnic groups and nationalities. Existing studies have shown that interventions such as psychotherapy, exercise therapy, and dietary supplement therapy can reduce the related symptoms caused by POF, and there are almost no adverse reactions, which seems to provide safe treatment options worth considering; however, due to the limited number of studies, the specific treatment mechanism is not clear and there is lack of empirical support.
Review ArticleResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
2022 Combinatorial Chemistry & High Throughput Screening A Network Pharmacology Study on the Similarities and Differences in the Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of Premature Ovarian Failure Shanshan Mei, Chaoqin Yu, Jie Ding, Wen Cheng
Network Pharmacology Ovarian Insufficiency
This study used a public database to identify the active ingredients and potential targets of the Zuo Gui Wan and You Gui Wan compounds. These were analyzed in relation to premature ovarian failure (POF) related genes obtained from OMIM and GeneCards. A protein-protein interaction network was established using STRING, and a drug-active ingredient-target gene network was constructed. The study thus identified similarities and differences in potential targets, active ingredients, and enriched pathways between the two compounds.
Analyzing the drug-target-pathway network revealed that both compounds contain multiple common active ingredients, as well as unique components, and share several targets in the treatment of POF, showing similar core mechanisms of action. However, each compound also targets some unique pathways, which indicates their differential approaches to POF treatment.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure
2022 Nov 26 Evidence-Based Complementary and Alternative Medicine Li M, Xiao YB, Wei L, Liu Q, Liu PY, Yao JF
Studies had shown that TCM prescription had therapeutic benefits by inhibiting apoptosis, slowing the aging process, promoting angiogenesis, and improving immunity to treat premature ovarian failure (POF).
Review ArticleCurrent Research on Complementary and Alternative Medicine in the Treatment of Premature Ovarian Failure: An Update Review
2022 Jun 23 Evidence-Based Complementary and Alternative Medicine Li Y, Yan MY, Chen QC, Xie YY, Li CY, Han FJ
In recent years, clinical and scientific researchers have paid more attention to POF and its associated symptoms such as amenorrhea and infertility. As the research has progressed, more and more CAM therapies have become widely accepted and well used, including herbal medicine, acupuncture, psychology, exercise, vitamins, massage, diet, etc. These therapies can significantly improve the patient's symptoms and hormone levels and can be used in combination with other treatments to enhance their efficacy.
Review Article Complementary MedicineThe Treatment of Complementary and Alternative Medicine on Premature Ovarian Failure
2021 Apr 15 Evidence-Based Complementary and Alternative Medicine Lin J, Wu D, Jia L, Liang M, Liu S, Qin Z, et al.
In conclusion, although the effectiveness of herbal therapy and acupuncture therapy has been well documented, it is difficult to make definitive recommendations for clinical guidance. Most of these studies are hindered by a small sample size or limited to one ethnic group, and there are few studies on adverse reactions, so it is not clear whether the effects of these treatments span all ethnic groups and nationalities. Existing studies have shown that interventions such as psychotherapy, exercise therapy, and dietary supplement therapy can reduce the related symptoms caused by POF, and there are almost no adverse reactions, which seems to provide safe treatment options worth considering; however, due to the limited number of studies, the specific treatment mechanism is not clear and there is lack of empirical support.
Review ArticlePresentation Slides
The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
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