Isoflavone
Recent Insights
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
Cholesterol High Blood Pressure Isoflavone
Equol, a powerful estrogen-like compound derived from soy, could be key to better health in postmenopausal women if gut microbiome could be altered to facilitate its production.
Gut Microbiota Isoflavone Oestrogen
Isoflavone supplementation noticeably impacts menopausal symptoms and hormonal changes in postmenopausal women.
Isoflavone Menopause Soybean
Natto and Miso, Japanese fermented soy foods, contain health-promoting bioactive components, including nattokinase, bacillopeptidase F, vitamin K2, dipicolinic acid, γ-polyglutamic acid, isoflavones, and phenolic acids.
Isoflavone Miso Natto
Isoflavones, mainly found in soy-derived products, show beneficial effects on bone health, potential cancer risk reduction, and alleviation of menopausal symptoms, but not on cardiovascular risk.
Breast Cancer Hot Flushes Isoflavone
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Estrogenic activity of fermented soymilk extracts and soy compounds
2023 Dec Applied Food Research Nishi K, Imamura I, Takemoto T, Iga K, Kiyama R
The study demonstrates the estrogenic activity of soymilk extracts and soy compounds, with greater activity observed after fermentation, highlighting complex mechanisms at the transcription level. RNA-sequencing analysis revealed up-regulation of genes related to cell division/cell cycle and DNA replication/DNA repair and down-regulation of genes associated with autophagy, suggesting enhanced cell proliferation. The estrogenic activity of soymilk extracts and soy flavonoids, especially after fermentation, offers potential pharmacological benefits, including bone protection, cancer chemoprevention, neuroprotection, and the treatment of menopausal syndromes.
Experimental Study Soy Milk MenopauseSoy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits
2023 Sep PharmaNutrition Tan ST, Tan SS, Tan CX
Review Article Type 2 Diabetes Soybean Osteoporosis Isoflavone Cholesterol High Blood PressureSoy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
Evaluating estrogenic activity of isoflavones inmisousing yeast two‐hybrid method
2023 Jun 06 Journal of Food Science Higa Y, Nagano R, Kanauchi M
Genistein in miso samples, particularly in Mame miso, showed high estrogenic activity against Y187-ββ modeling hERββ. Isoflavones in miso inhibited the estrogenic activity of 17β-estradiol against Y187-αα but activated the activity against Y187-αβ and Y187-ββ, modeling hER-αβ and hER-ββ. Genistein was identified as an antagonist of estrogenic activity against hERαα but an agonist against hERαβ and hERββ.
Experimental Study Miso
Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss
2023 Jan 01 JAMA Dermatology Drake L, Reyes-Hadsall S, Martinez J, Heinrich C, Huang K, Mostaghimi A
Dietary and nutritional interventions, including Viviscal, Nourkrin, Nutrafol, Lamdapil, Pantogar, capsaicin and isoflavone, omegas 3 and 6 with antioxidants, apple nutraceutical, total glucosides of paeony and compound glycyrrhizin tablets, zinc, tocotrienol, pumpkin seed oil, Kimchi and cheonggukjang, vitamin D3, and Forti5, showed varying levels of evidence for potential benefits in improving disease course, with rare and mild adverse effects.
Systematic Review Randomised Controlled Trial
Black soybean (Glycine max(L.) Merr.): paving the way toward new nutraceutical
2022 Feb 10 Critical Reviews in Food Science and Nutrition Kumar M, Suhag R, Hasan M, Dhumal S, Radha , Pandiselvam R, et al.
Review Article Black SoybeanModern extraction techniques improve the extraction of bioactive compounds from black soybeans, which have potential use in functional foods and nutraceutical components.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
2023 PharmaNutrition Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits Tan ST, Tan SS, Tan CX
Review Article Cholesterol High Blood Pressure Osteoporosis
Methodology: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. It began with a sophisticated multi-database search, featuring resources like Google Scholar, Scopus, and others. This search targeted articles published from 2017 to March 2023 and used specific keywords for accuracy. Forty-three articles were handpicked from this process after excluding reviews, conference reports, duplicates, inaccessible texts, and any non-English publications.
Discussion of Results: A thorough examination of the chosen articles resulted in the conclusion that soy proteins, soy bioactive peptides, and soy isoflavones are typically safe for human consumption. Furthermore, it was found that the consumption of these compounds may have beneficial effects, potentially lowering risk factors for ailments such as osteoporosis, various cancers, hypertension, atherosclerosis, and more.
Modern extraction techniques improve the extraction of bioactive compounds from black soybeans, which have potential use in functional foods and nutraceutical components.
2022 Critical Reviews in Food Science and Nutrition Black soybean (Glycine max(L.) Merr.): paving the way toward new nutraceutical Kumar M, Suhag R, Hasan M, Dhumal S, Radha , Pandiselvam R, et al.
Review Article Black Soybean
These modern extraction techniques involve the application of technologies such as microwaves, ultrasounds, and enzymes. Contrary to traditional methods that depend on simple yet toxic solvents, these contemporary options yield higher amounts of bioactive substances from black soybeans, are quicker, and are less damaging to the environment. The exact bioactive compounds extracted include anthocyanins, phenolic acids, isoflavones, and flavones, among others.
Researchers discovered that black soybeans, and specifically their seed coat, are rich in various bioactive compounds. These compounds have been reported to possess numerous health benefits, showing antioxidant, anti-cancer, anti-diabetic, anti-obesity, anti-inflammatory, cardio and neuroprotective activities. The study also explores how these soybean extracts have been used in the manufacture of food products like noodles, in the development of biodegradable films with pH sensitivity, and in therapeutic applications such as promoting wound healing and alleviating inflammation. The comprehensive review, therefore, serves as a handy reference for food manufacturers and scientists, showcasing the vast potential of black soybeans in the development of functional foods and nutraceuticals.
Equol, a powerful estrogen-like compound derived from soy, could be key to better health in postmenopausal women if gut microbiome could be altered to facilitate its production.
2022 Nutrients Maximizing the Estrogenic Potential of Soy Isoflavones through the Gut Microbiome: Implication for Cardiometabolic Health in Postmenopausal Women Leonard LM, Choi MS, Cross TWL
Review Article Gut Microbiota Oestrogen Soybean
The methodology of this research involved looking closely at the properties and actions of equol, a metabolite of the soy isoflavone daidzein. This substance is produced through the process of intestinal bacterial metabolism, but the ability to produce it is not present in over half of the human population due to the absence of specific equol-producing bacteria in the gastrointestinal tract. Given that the make up of the gut microbiome varies from person to person, understanding the effects of equol and daidzein in the human body has been a complex task. Furthermore, the fact that rodents easily produce equol complicates the matter, as findings from rodent models may not directly apply to humans.
While interpreting the results, it was found that equol, due to its strong estrogenic activity, could potentially be an excellent means to manage postmenopausal symptoms and overall health. However, the ability to produce equol varies significantly among people, based on the bacterial microflora of their gut. Therefore, the benefits of equol could potentially be amplified by finding effective methods to manipulate the gut microbiome to foster equol production, a strategy that could lead to improved health outcomes for postmenopausal women.
Isoflavone supplementation noticeably impacts menopausal symptoms and hormonal changes in postmenopausal women.
2022 Nutrition Research and Practice Effect of isoflavone supplementation on menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials Kang I, Rim CH, Yang HS, Choe JS, Kim JY, Lee M
Meta-Analysis Menopause Soybean
In order to examine isoflavones effects on menopausal symptoms and the associated hormonal alterations, a systematic review and meta-analysis were conducted. To do this, the PubMed and EMBASE databases were used, but the selected studies were restricted to random controlled trials (RCTs) assessing isoflavone supplementation's impact on menopausal symptoms. Overall, 11 studies were chosen for the final quantitative evaluation, and the isoflavone intervention amount varied among these studies.
The Meta-analysis displayed that supplementing isoflavones meaningfully increased estradiol levels and the Kupperman index (a composite scoring of multiple menopausal symptoms intensity). Yet, there were no significant impacts observed on hot flashes, or the release of two specific hormones: follicle-stimulating hormone and luteinizing hormone. It should be noted that there was a significant inconsistency in estradiol levels and Kupperman index findings among different studies.
Natto and Miso, Japanese fermented soy foods, contain health-promoting bioactive components, including nattokinase, bacillopeptidase F, vitamin K2, dipicolinic acid, γ-polyglutamic acid, isoflavones, and phenolic acids.
2021 Food Research Natto and miso: an overview on their preparation, bioactive components and health-promoting effects Chan EWC, Wong SK, Kezuka M, Oshiro N, Chan HT
Review Article Miso Natto
The process of preparing natto involves fermenting cooked soybeans with Bacillus subtilis natto. This gives the soybeans a sticky appearance, a slippery texture, a sour aroma and a nutty flavour, and results in the production of bioactive components such as nattokinase, bacillopeptidase F, vitamin K2, dipicolinic acid, and γ-polyglutamic acid. Miso, on the other hand, refers to a paste produced by fermenting cooked soybeans with koji, which is steamed rice inoculated with Aspergillus oryzae.
The health benefits of these bioactive components, produced during the fermentation process of both natto and miso, have been identified and accentuated. These components add value to traditional soy foods, boosting their potential in promoting health. The wealth of bioactive nutrients in these foods indicate the reiterate the importance of traditional fermented foods in dietary practices.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits
2023 Sep PharmaNutrition Tan ST, Tan SS, Tan CX
Review Article Type 2 Diabetes Soybean Osteoporosis Isoflavone Cholesterol High Blood PressureSoy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss
2023 Jan 01 JAMA Dermatology Drake L, Reyes-Hadsall S, Martinez J, Heinrich C, Huang K, Mostaghimi A
Dietary and nutritional interventions, including Viviscal, Nourkrin, Nutrafol, Lamdapil, Pantogar, capsaicin and isoflavone, omegas 3 and 6 with antioxidants, apple nutraceutical, total glucosides of paeony and compound glycyrrhizin tablets, zinc, tocotrienol, pumpkin seed oil, Kimchi and cheonggukjang, vitamin D3, and Forti5, showed varying levels of evidence for potential benefits in improving disease course, with rare and mild adverse effects.
Systematic Review Randomised Controlled TrialBlack soybean (Glycine max(L.) Merr.): paving the way toward new nutraceutical
2022 Feb 10 Critical Reviews in Food Science and Nutrition Kumar M, Suhag R, Hasan M, Dhumal S, Radha , Pandiselvam R, et al.
Review Article Black SoybeanModern extraction techniques improve the extraction of bioactive compounds from black soybeans, which have potential use in functional foods and nutraceutical components.
Effect of isoflavone supplementation on menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials
2022 Jan Nutrition Research and Practice Kang I, Rim CH, Yang HS, Choe JS, Kim JY, Lee M
Meta-Analysis Systematic Review Isoflavone Soybean MenopauseIsoflavone supplementation noticeably impacts menopausal symptoms and hormonal changes in postmenopausal women.
Maximizing the Estrogenic Potential of Soy Isoflavones through the Gut Microbiome: Implication for Cardiometabolic Health in Postmenopausal Women
2022 Jan 27 Nutrients Leonard LM, Choi MS, Cross TWL
Review Article Gut Microbiota Oestrogen Soybean IsoflavoneEquol, a powerful estrogen-like compound derived from soy, could be key to better health in postmenopausal women if gut microbiome could be altered to facilitate its production.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Presentation Slides
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
Modern extraction techniques improve the extraction of bioactive compounds from black soybeans, which have potential use in functional foods and nutraceutical components.
Equol, a powerful estrogen-like compound derived from soy, could be key to better health in postmenopausal women if gut microbiome could be altered to facilitate its production.
Isoflavone supplementation noticeably impacts menopausal symptoms and hormonal changes in postmenopausal women.
Natto and Miso, Japanese fermented soy foods, contain health-promoting bioactive components, including nattokinase, bacillopeptidase F, vitamin K2, dipicolinic acid, γ-polyglutamic acid, isoflavones, and phenolic acids.
Isoflavones found in soybeans can reduce risks of certain cancers and alleviate menopause-related symptoms among women, such as vasomotor syndromes, spinal bone loss, and hypertension.
Isoflavones, mainly found in soy-derived products, show beneficial effects on bone health, potential cancer risk reduction, and alleviation of menopausal symptoms, but not on cardiovascular risk.
Soybean isoflavones, whether extracted or synthesized, prove significantly effective in reducing the frequency and severity of hot flashes in perimenopausal and postmenopausal women.
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The ability to produce it is not present in over half of the human population due to the absence of specific equol-producing bacteria in the gastrointestinal tract. —Jinnan C 22 Jan 2024