Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
How to submit an article:
- Registered users can submit any published journal article that has a unique DOI (Digital Object Identifier) name or link to Research Hub.
- For example, you can paste the full DOI link:
https://doi.org/10.1109/5.771073
or just the DOI name: 10.1109/5.771073
into the field above and click submit.
- The person who is first to submit a valid article to Research Hub will forever be credited for it, and every article submission earns you +6 Research Points.
Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment
2022 May Phytomedicine Xue P, Zhang G, Zhang J, Ren L
Review Article Experimental Study Pomegranate Radiotherapy Chemotherapy Ellagic Acid Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects.
The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells
2022 Jan Human & Experimental Toxicology Cheshomi H, Bahrami AR, Rafatpanah H, Matin MM
Experimental Study Animal Study Ellagic Acid Stomach Cancer Pomegranate Ellagic acid, found naturally in pomegranates, significantly inhibits growth and migration of gastric cancer cells without causing notable side effects.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects.
Review Article Chemotherapy Pomegranate Radiotherapy
The presented review compiled in vitro and in vivo experimental evidence of the synergistic effect of Ellagic acid (EA) in cancer therapy from multiple databases including PubMed, Web of Science, and Google Scholar. The focus was on the use of EA in conjunction with conservative treatment methods such as chemotherapy and radiotherapy.
The results suggest that EA, a polyphenolic compound found in various plant foods, has the potential to enhance the effectiveness of these treatment methods. It was found to improve treatment outcomes when combined with a low dosage of therapeutic drugs or optimized radiation levels. Additionally, EA appears to have a preventative effect against the adverse reactions normally associated with chemotherapy, possibly due to its antioxidant and anti-inflammatory properties. This makes it a promising candidate as a drug adjuvant in cancer treatment.
View Article
Ellagic acid, found naturally in pomegranates, significantly inhibits growth and migration of gastric cancer cells without causing notable side effects.
Experimental Study Pomegranate Stomach Cancer
In the methodology of this study, High Performance Liquid Chromatography (HPLC) was employed to detect the presence of Ellagic Acid (EA) in samples. Various methods were then used to determine the various anti-cancer properties of different concentrations of pomegranate fruit juice, pomegranate peel extract, and pure EA. This included an MTT assay, apoptosis and scratch assay, gelatin zymography and quantitative RT-PCR. Additionally, the study examined the impact of these compounds on immunocompromised C57BL/6 mice carrying human gastric cancer tumors.
Extending to discussing the results, it was found that EA inhibited both the proliferation and migration of gastric cancer cells in mice and altered gene expressions related to apoptosis and inflammation. The treatments with EA or pomegranate extract resulted in a noticeable decrease in tumor size in the lab mice. No significant side effects were reported from EA use. In sum, the results showed EA's potential as a safe and effective anti-cancer agent specific to gastric adenocarcinoma.
View Article
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Chinese Medicine Research Hub
Review Article
Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects.
2022 Phytomedicine Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment
Xue P, Zhang G, Zhang J, Ren L
Chinese Medicine Research Hub
Experimental Study
Ellagic acid, found naturally in pomegranates, significantly inhibits growth and migration of gastric cancer cells without causing notable side effects.
2022 Human & Experimental Toxicology The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells
Cheshomi H, Bahrami AR, Rafatpanah H, Matin MM
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Ellagic Acid" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Ellagic Acid" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Ellagic Acid" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Review Article published in 2022 in the journal Phytomedicine found that Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects. The presented review compiled in vitro and in vivo experimental evidence of the synergistic effect of Ellagic acid (EA) in cancer therapy from multiple databases including PubMed, Web of Science, and Google Scholar. The focus was on the use of EA in conjunction with conservative treatment methods such as chemotherapy and radiotherapy.
The results suggest that EA, a polyphenolic compound found in various plant foods, has the potential to enhance the effectiveness of these treatment methods. It was found to improve treatment outcomes when combined with a low dosage of therapeutic drugs or optimized radiation levels. Additionally, EA appears to have a preventative effect against the adverse reactions normally associated with chemotherapy, possibly due to its antioxidant and anti-inflammatory properties. This makes it a promising candidate as a drug adjuvant in cancer treatment.
A Experimental Study published in 2022 in the journal Human & Experimental Toxicology found that Ellagic acid, found naturally in pomegranates, significantly inhibits growth and migration of gastric cancer cells without causing notable side effects. In the methodology of this study, High Performance Liquid Chromatography (HPLC) was employed to detect the presence of Ellagic Acid (EA) in samples. Various methods were then used to determine the various anti-cancer properties of different concentrations of pomegranate fruit juice, pomegranate peel extract, and pure EA. This included an MTT assay, apoptosis and scratch assay, gelatin zymography and quantitative RT-PCR. Additionally, the study examined the impact of these compounds on immunocompromised C57BL/6 mice carrying human gastric cancer tumors.
Extending to discussing the results, it was found that EA inhibited both the proliferation and migration of gastric cancer cells in mice and altered gene expressions related to apoptosis and inflammation. The treatments with EA or pomegranate extract resulted in a noticeable decrease in tumor size in the lab mice. No significant side effects were reported from EA use. In sum, the results showed EA's potential as a safe and effective anti-cancer agent specific to gastric adenocarcinoma.