Ellagic Acid

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Chinese Medicine Research Hub

Review Article

Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects.

2022 Phytomedicine Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment
Xue P, Zhang G, Zhang J, Ren L

Chinese Medicine Research Hub

Ellagic acid, found naturally in pomegranates, significantly inhibits growth and migration of gastric cancer cells without causing notable side effects.

2022 Human & Experimental Toxicology The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells
Cheshomi H, Bahrami AR, Rafatpanah H, Matin MM

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Ellagic Acid" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Ellagic Acid" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Ellagic Acid" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2022 in the journal Phytomedicine found that Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects. The presented review compiled in vitro and in vivo experimental evidence of the synergistic effect of Ellagic acid (EA) in cancer therapy from multiple databases including PubMed, Web of Science, and Google Scholar. The focus was on the use of EA in conjunction with conservative treatment methods such as chemotherapy and radiotherapy. The results suggest that EA, a polyphenolic compound found in various plant foods, has the potential to enhance the effectiveness of these treatment methods. It was found to improve treatment outcomes when combined with a low dosage of therapeutic drugs or optimized radiation levels. Additionally, EA appears to have a preventative effect against the adverse reactions normally associated with chemotherapy, possibly due to its antioxidant and anti-inflammatory properties. This makes it a promising candidate as a drug adjuvant in cancer treatment.

A published in 2022 in the journal Human & Experimental Toxicology found that Ellagic acid, found naturally in pomegranates, significantly inhibits growth and migration of gastric cancer cells without causing notable side effects. In the methodology of this study, High Performance Liquid Chromatography (HPLC) was employed to detect the presence of Ellagic Acid (EA) in samples. Various methods were then used to determine the various anti-cancer properties of different concentrations of pomegranate fruit juice, pomegranate peel extract, and pure EA. This included an MTT assay, apoptosis and scratch assay, gelatin zymography and quantitative RT-PCR. Additionally, the study examined the impact of these compounds on immunocompromised C57BL/6 mice carrying human gastric cancer tumors. Extending to discussing the results, it was found that EA inhibited both the proliferation and migration of gastric cancer cells in mice and altered gene expressions related to apoptosis and inflammation. The treatments with EA or pomegranate extract resulted in a noticeable decrease in tumor size in the lab mice. No significant side effects were reported from EA use. In sum, the results showed EA's potential as a safe and effective anti-cancer agent specific to gastric adenocarcinoma.

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