Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Dietary strategies, such as caloric restriction and ketogenic diets, can alleviate chronic pain and enhance quality of life.
Systematic Review Caloric Restriction Intermittent Fasting Mediterranean Diet
This systematic review selected 16 articles from various databases including PubMed, Web of Sciences, ProQuest, and Scopus that were published within the last 6 years. These consisted of randomized clinical trials (RCTs), observational studies, and systematic reviews evaluating the effectiveness of different dietary strategies in the treatment of chronic pain. A range of assessment scales—PEDro, PVI, QUALSYT and the Quality Assessment Tool of Systematic Reviews scale— were utilized to gauge the risk of bias in these studies.
The findings indicate an inconclusive consensus on the impact of an intermittent fasting (IF) diet on pain improvement. However, a caloric restriction diet emerged as a potential long-term treatment option for pain. Additionally, time-restricted food and ketogenic diets showed promising results in improving life quality in chronic conditions. Despite some studies indicating opposite results, the majority of the selected articles exhibited good methodological quality on their respective assessment scales.
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The ketogenic diet, by reducing carbohydrate intake, shows potential in weight loss, insulin requirement reduction, and mitigation of inflammatory symptoms in patients with inflammatory arthritis.
Review Article Cardiovascular Disease Rheumatoid Arthritis
The ketogenic diet operates on the principle of substantially limiting carbohydrate consumption with a daily calorie percentage between 5-10%, facilitating a metabolic switch towards the use of ketone bodies. Studies indicate promise in a variety of applications including weight loss, insulin requirement minimization in diabetes, cancer protocol supplementation, neurological treatment, and control optimization for metabolic and cardiovascular diseases. Although literature on the anti-inflammatory properties of the ketogenic diet on rheumatic diseases is somewhat limited, their beneficial effects on weight loss are evidenced by related biomechanical and biochemical factors.
Obesity is recognized to stimulate macrophage activation and generate pro-inflammatory cytokines including TNF-α, IL-1b, and IL-6. Furthermore, scientists believe that the ketogenic diet’s primary clinical effect could be linked to the enhancement of insulin sensitivity. Insulin resistance demonstrates a correlation with increased TNF-α, IL-1α, IL-1β, IL-6, and leptin. Additionally, reduction in body adipose tissue and weight loss contribute to the anti-inflammatory effects and their impact on cardiovascular health.
Within the context of rheumatoid arthritis, fasting has been shown to reduce disease symptoms, potentially through the production of a key ketone body, β-hydroxybutyrate, which may also stifle IL-17. This, combined with intermittent fasting, was shown to provide symptomatic improvements in psoriatic arthritis. However, the current literature does not allow for definitive conclusions regarding the effects of a ketogenic diet on ankylosing spondylitis.
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Presentation Slides
Chinese Medicine Research Hub
Systematic Review
Dietary strategies, such as caloric restriction and ketogenic diets, can alleviate chronic pain and enhance quality of life.
2022 International Journal of Environmental Research and Public Health The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review
Cuevas-Cervera M, Perez-Montilla J, Gonzalez-Muñoz A, Garcia-Rios M, Navarro-Ledesma S
Chinese Medicine Research Hub
Review Article
The ketogenic diet, by reducing carbohydrate intake, shows potential in weight loss, insulin requirement reduction, and mitigation of inflammatory symptoms in patients with inflammatory arthritis.
2021 Frontiers in Medicine The Effect of Ketogenic Diet on Inflammatory Arthritis and Cardiovascular Health in Rheumatic Conditions: A Mini Review
Ciaffi J, Mitselman D, Mancarella L, Brusi V, Lisi L, Ruscitti P, Cipriani P, Meliconi R, Giacomelli R, Borghi C, Ursini F
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Ketogenic Diet" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Ketogenic Diet" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Ketogenic Diet" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Systematic Review published in 2022 in the journal International Journal of Environmental Research and Public Health found that Dietary strategies, such as caloric restriction and ketogenic diets, can alleviate chronic pain and enhance quality of life. This systematic review selected 16 articles from various databases including PubMed, Web of Sciences, ProQuest, and Scopus that were published within the last 6 years. These consisted of randomized clinical trials (RCTs), observational studies, and systematic reviews evaluating the effectiveness of different dietary strategies in the treatment of chronic pain. A range of assessment scales—PEDro, PVI, QUALSYT and the Quality Assessment Tool of Systematic Reviews scale— were utilized to gauge the risk of bias in these studies.
The findings indicate an inconclusive consensus on the impact of an intermittent fasting (IF) diet on pain improvement. However, a caloric restriction diet emerged as a potential long-term treatment option for pain. Additionally, time-restricted food and ketogenic diets showed promising results in improving life quality in chronic conditions. Despite some studies indicating opposite results, the majority of the selected articles exhibited good methodological quality on their respective assessment scales.
A Review Article published in 2021 in the journal Frontiers in Medicine found that The ketogenic diet, by reducing carbohydrate intake, shows potential in weight loss, insulin requirement reduction, and mitigation of inflammatory symptoms in patients with inflammatory arthritis. The ketogenic diet operates on the principle of substantially limiting carbohydrate consumption with a daily calorie percentage between 5-10%, facilitating a metabolic switch towards the use of ketone bodies. Studies indicate promise in a variety of applications including weight loss, insulin requirement minimization in diabetes, cancer protocol supplementation, neurological treatment, and control optimization for metabolic and cardiovascular diseases. Although literature on the anti-inflammatory properties of the ketogenic diet on rheumatic diseases is somewhat limited, their beneficial effects on weight loss are evidenced by related biomechanical and biochemical factors.
Obesity is recognized to stimulate macrophage activation and generate pro-inflammatory cytokines including TNF-α, IL-1b, and IL-6. Furthermore, scientists believe that the ketogenic diet’s primary clinical effect could be linked to the enhancement of insulin sensitivity. Insulin resistance demonstrates a correlation with increased TNF-α, IL-1α, IL-1β, IL-6, and leptin. Additionally, reduction in body adipose tissue and weight loss contribute to the anti-inflammatory effects and their impact on cardiovascular health.
Within the context of rheumatoid arthritis, fasting has been shown to reduce disease symptoms, potentially through the production of a key ketone body, β-hydroxybutyrate, which may also stifle IL-17. This, combined with intermittent fasting, was shown to provide symptomatic improvements in psoriatic arthritis. However, the current literature does not allow for definitive conclusions regarding the effects of a ketogenic diet on ankylosing spondylitis.