Sesame

Presentation Slides

Chinese Medicine Research Hub

Systematic Review

Consumption of sesame seeds and its products positively influences human glucose metabolism, potentially making it a beneficial addition to glucose-lowering diets.

2022 Phytotherapy Research Consumption of sesame seeds and sesame products has favorable effects on blood glucose levels but not on insulin resistance: A systematic review and meta‐analysis of controlled clinical trials
Sohouli MH, Haghshenas N, Hernández‐Ruiz , Shidfar F

Chinese Medicine Research Hub

Systematic Review

Sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants.

2019 Food Reviews International Sesame Seed and Its Fractions for Improving Oxidative Stress in Adults: A Systematic Review and Meta-analysis of Controlled Clinical Trials
Moghtaderi F, Ramezani-Jolfaie N, Raeisi-Dehkordi H, Salehi-Abargouei A

Chinese Medicine Research Hub

Systematic Review

Sesame oil intake was associated with reduced body weight and body mass index.

2018 Journal of Functional Foods Do sesame seed and its products affect body weight and composition? A systematic review and meta-analysis of controlled clinical trials
Raeisi-Dehkordi H, Mohammadi M, Moghtaderi F, Salehi-Abargouei A

Chinese Medicine Research Hub

Systematic Review

The biomarkers that were significantly different between black seeds and white sesame seeds are highly related to the functions recorded in traditional Chinese medicine.

2018 Molecules Identification of Nutritional Components in Black Sesame Determined by Widely Targeted Metabolomics and Traditional Chinese Medicines
Wang D, Zhang L, Huang X, Wang X, Yang R, Mao J, Wang X, Wang X, Zhang Q, Li P.

Chinese Medicine Research Hub

Systematic Review

Of the 7 clinical trials included, five evaluating individuals with hypertension observed a significant reduction in systolic and/or diastolic blood pressure. The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile.

2017 Critical Reviews in Food Science and Nutrition The effect of dietary intake of sesame (Sesamumindicum L.) derivatives related to the lipid profile and blood pressure: A systematic review
Carolina Alves Cardoso, Gláucia Maria Moraes de Oliveira, Luciana de Almeida Vittori Gouveia, Annie Seixas Bello Moreira & Glorimar Rosa

Chinese Medicine Research Hub

Systematic Review

The studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied.

2016 Journal of Medicinal Food Effects of the Intake of Sesame Seeds (Sesamum indicum L.) and Derivatives on Oxidative Stress: A Systematic Review
Gouveia Lde A, Cardoso CA, de Oliveira GM, Rosa G, Moreira AS.

Chinese Medicine Research Hub

Systematic Review

These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress.

2011 Nutrition Journal Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans
Wichitsranoi, J., Weerapreeyakul, N., Boonsiri, P. et al.

Executive Summary

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Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Sesame" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2022 in the journal Phytotherapy Research found that Consumption of sesame seeds and its products positively influences human glucose metabolism, potentially making it a beneficial addition to glucose-lowering diets. The methodology involved conducting a systematic review and meta-analysis on the effect of sesame seeds consumption on blood glucose and insulin resistance in adults. The researchers gathered data from recognized academic resources like PubMed/MEDLINE, SCOPUS, Web of Science, Google Scholar, and EMBASE, which included controlled clinical trials up until February 2021. The sesame products in these trials ranged from sesame oil, sesamin, and tahini, with the intervention period lasting from 45 days to 9 weeks. The results illustrate that the intake of sesame and its products significantly improved fasting blood glucose and Hemoglobin A1c levels. Nonetheless, the results regarding fasting serum insulin and the homeostatic model assessment for insulin resistance were not found to have any significant relation. Hence, the consumption of sesame might be a beneficial supplement for managing glucose levels in humans.

A Systematic Review published in 2019 in the journal Food Reviews International found that Sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants. Meta-analyses revealed that sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants. However, no significant effect was observed on malondialdehyde (MDA), total antioxidant capacity and α-tocopherol levels. It was shown that MDA levels significantly decreases only when sesame seeds were used for supplementation. Sesame consumption is associated with improved oxidative status. High quality randomized controlled clinical trials from diverse regions are still needed.

A Systematic Review published in 2018 in the journal Journal of Functional Foods found that Sesame oil intake was associated with reduced body weight and body mass index. A number of studies suggested that sesame products improve body weight and composition. This was the first meta-analysis of the effect of sesame on body weight and composition. Ten controlled clinical trials were eligible to be included in the systematic review. Sesame supplementation improved body fat percent and body adiposity index. Sesame oil intake was associated with reduced body weight and body mass index. Sesame consumption did not affect other indices of body composition.

A Systematic Review published in 2018 in the journal Molecules found that The biomarkers that were significantly different between black seeds and white sesame seeds are highly related to the functions recorded in traditional Chinese medicine. Chemical composition of secondary metabolites is of great importance for quality control of agricultural products. Black sesame seeds are significantly more expensive than white sesame seeds, because it is thought that black sesame seeds are more beneficial to human health than white sesame seeds. However, the differences in nutrient composition between black sesame seeds and white sesame seeds are still unknown. The current study examined the levels of different metabolites in black and white sesame seeds via the use of a novel metabolomics strategy. Using widely targeted metabolomics data, we obtained the structure and content of 557 metabolites, out of which 217 metabolites were identified, and discovered 30 metabolic pathways activated by the secondary metabolites in both black and white sesame seeds. Our results demonstrated that the main pathways that were differentially activated included: phenylpropanoid biosynthesis, tyrosine metabolism, and riboflavin metabolism. More importantly, the biomarkers that were significantly different between black seeds and white sesame seeds are highly related to the functions recorded in traditional Chinese medicine. The results of this study may serve as a new theoretical reference for breeding experts to promote the genetic improvement of sesame seeds, and therefore the cultivation of higher quality sesame varieties.

A Systematic Review published in 2017 in the journal Critical Reviews in Food Science and Nutrition found that Of the 7 clinical trials included, five evaluating individuals with hypertension observed a significant reduction in systolic and/or diastolic blood pressure. The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile. The mechanisms of action are still being studied. Regarding the bias risk analysis, clinical trials included showed few descriptions of the methods applied. There are few studies about sesame ingestion, and it was observed high risk for bias in the selected studies. More standardized methods with attention to the design of studies are needed to improve the level of the evidence.

A Systematic Review published in 2016 in the journal Journal of Medicinal Food found that The studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied. In conclusion, despite the limitations and biases of this systematic review, the studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied (individuals with dyslipidemia, diabetes, and hypertension), as well as in its different presentations (oil, seed flour, and capsule). However, better-controlled studies still lack to assess the positive effects on different populations. There are few clinical trials assessing the effect of sesame on oxidative stress. The studies included in this review, mainly those with sesame oil and black sesame meal capsules administered to hypertensive and prehypertensive populations, respectively, showed an increase in enzymatic (SOD, GSH, GPx, and CAT) and nonenzymatic antioxidants (vitamin C, vitamin E, and beta-carotene), as well as a reduction in oxidative stress markers (TBARS and MDA). Although several studies have reported that the exact mechanisms of oxidative stress reduction remain to be fully explained, this review showed that sesame can have a significant positive impact on the health of different popula- tions.

A Systematic Review published in 2011 in the journal Nutrition Journal found that These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. This study suggests a beneficial effect of dietary black sesame meal on a reduction in blood pressure in pre-hypertensive humans. It is likely that the antihypertensive effect is due to decreased oxidative stress. Taken together with the absence of side effects and inexpensive preparation, the regular ingestion of dietary black sesame meal may be beneficial for CVD prevention in individuals with prehypertension, or even those with hypertension. A future study that investigates this advantageous effect is suggested.

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