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2017 The Lancet
Cervical Cancer EGCG HPV
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Chinese Medicine Research Hub
The major bioactive polyphenol in green tea, EGCG, could potentially reverse the abnormal changes induced by oncogenic HPV strains.
2017 The Lancet The effectiveness of epigallocathechin-3-gallate for treatment of human papillomavirus-driven epithelial neoplasms: a preclinical study
Yap J, Luesley D, Woodman C, Dawson C
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Neoplasm" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Neoplasm" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Neoplasm" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A published in 2017 in the journal The Lancet found that The major bioactive polyphenol in green tea, EGCG, could potentially reverse the abnormal changes induced by oncogenic HPV strains. Methodology: This research involved organotypic raft cultures of keratinocytes infected with HPV18. The culture was established at an air-liquid interface for 10 days and then treated with EGCG for an additional 10 days. The treated raft sections were stained using antibodies specifically targeting cell proliferation, keratinocyte differentiation markers, and tumor suppressor genes. Further, western blotting was utilized on EGCG-treated cells to determine the levels of HPV18 E6 and E7 protein expression.
Results: It was observed that the EGCG treatment blocked the ability of HPV18-positive keratinocytes to produce hyperplastic epithelium within the raft culture. EGCG allowed for a decline in cell proliferation as confirmed by bromodeoxyuridine label incorporation and Ki67 staining, and it led to the upregulated expression of various tumor suppressor genes. Meanwhile, productive viral replication was impaired. Importantly, the treatment did not significantly impact keratinocyte differentiation. Rather, EGCG treatment in the culture encouraged the degradation of E6 and E7 proteins and reinstated the tumor suppressor gene expression.
Full Text not available. —Ve-Vinn L 24 Sep 2021