Adenomyosis

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Chinese Medicine Research Hub

Review Article

Green tea helps alleviate symptoms in multiple benign gynecological disorders, primarily due to a compound called Epigallocatechin-3-gallate.

2023 Nutrients Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
Hazimeh D, Massoud G, Parish M, Singh B, Segars J, Islam MS

Chinese Medicine Research Hub

Network Pharmacology

Gui Zhi Fu Ling Wan can lessen the expression of certain proteins, which may be key to its ability to impede abnormal tissue invasion and metastasis in adenomyosis.

2022 Evidence-Based Complementary and Alternative Medicine Analysis of the Mechanism of GuizhiFuling Wan in Treating Adenomyosis Based on Network Pharmacology Combined with Molecular Docking and Experimental Verification
Shi Y, Zhang C, Wang X, Wang Z, Zhang Y, Liu Z, Wang X, Shi W

Chinese Medicine Research Hub

Systematic Review

Acupuncture shows promising potential in providing symptom relief for women with adenomyosis and may be considered as an alternative treatment to surgery and pharmacological medicine, based on a systematic review and meta-analysis of randomized controlled trials.

2022 Acupuncture & Electro-Therapeutics Research Short-term Outcomes of Acupuncture Interventions on Uterine Adenomyosis: A Systematic Review and Meta-analysis
Li Q, Li YX, Fan L, Yuan SE

Chinese Medicine Research Hub

Network Pharmacology

Gui Zhi Fu Ling Wan treats adenomyosis by intervening in local estrogen signalling pathways and affecting estrogen resistance via myometrium signalling pathways.

2021 Evidence-Based Complementary and Alternative Medicine Integrating Network Pharmacology and Experimental Validation Deciphers the Mechanism of Guizhi Fuling Wan against Adenomyosis
Wang H, Zhang J, Zhu Q, Fu X, Li C

Chinese Medicine Research Hub

Systematic Review

Endometriosis and Adenomyosis can have impact on miscarriage risk in pregnancy.

2020 BioMed Research International Miscarriage on Endometriosis and Adenomyosis in Women by Assisted Reproductive Technology or with Spontaneous Conception: A Systematic Review and Meta-Analysis
Yangxue Huang, Xianhong Zhao, Yiyuan Chen, Jie Wang, Weilin Zheng, Lixing Cao

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Adenomyosis" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Adenomyosis" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Adenomyosis" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2023 in the journal Nutrients found that Green tea helps alleviate symptoms in multiple benign gynecological disorders, primarily due to a compound called Epigallocatechin-3-gallate. The paper reviews the role of the compound Epigallocatechin-3-gallate found in green tea, and its effects on various benign gynecological conditions. The compound is noted for its antioxidant and prooxidant qualities, allowing it to interact with multiple cellular pathways that are crucial for disease pathogenesis. The studied conditions include uterine fibroids, endometriosis, dysmenorrhea, adenomyosis, menopause, and polycystic ovary syndrome. The research accounts for the specific mechanisms through which the compound might affect each condition, such as anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms. The results suggest that green tea consumption can lead to improved symptom management in these disorders. It was found to lessen the intensity of symptoms associated with uterine fibroids and endometriosis, by invoking anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms. It also helped manage pain linked with dysmenorrhea and adenomyosis through reducing uterine contractility and widely felt pain. Additionally, it showed efficacy in weight and osteoporosis control during menopause, and showed potential benefits in managing polycystic ovary syndrome. However, claims regarding its influence on fertility were deemed controversial.

A Network Pharmacology published in 2022 in the journal Evidence-Based Complementary and Alternative Medicine found that Gui Zhi Fu Ling Wan can lessen the expression of certain proteins, which may be key to its ability to impede abnormal tissue invasion and metastasis in adenomyosis. Firstly, an approach called network pharmacology was utilized which involved identifying active components of GuizhiFuling Wan (GFW), its drug targets and disease targets through public databases, and finding shared targets. The biological function and pathway of GFW in treating adenomyosis were analyzed. Then, the interaction and strength of binding between key components and targets of GFW were verified by a method known as molecular docking. In the animal part of the study, the impact of GFW on the expression of several proteins in mice with adenomyosis was observed using different staining, protein analysis, and immunohistochemical techniques. Through collecting and intersecting data, 26 common targets were identified, with the key active compounds being baicalein, sitosterol, and -sitosterol, and the key targets being certain proteins. Enrichment analyses showed that processes such as the positive regulation of vascular endothelial migration and signaling pathways were involved in regulating angiogenesis, invasion, and metastasis in adenomyosis. Furthermore, the molecular docking results suggested that the key active compounds had substantial binding potential with the key proteins. In vivo analysis suggested that GFW could decrease the serum content and protein expression of certain proteins in mice with adenomyosis. These findings reinforce the hypothesis that reducing the expression of these proteins might be a significant mechanism for GFW in inhibiting the invasion and metastasis of atypical tissues associated with adenomyosis.

A Systematic Review published in 2022 in the journal Acupuncture & Electro-Therapeutics Research found that Acupuncture shows promising potential in providing symptom relief for women with adenomyosis and may be considered as an alternative treatment to surgery and pharmacological medicine, based on a systematic review and meta-analysis of randomized controlled trials. This systematic review examined the effects of acupuncture on relieving adenomyosis symptoms. Eleven randomized controlled trials involving 942 women were included. Acupuncture was found to significantly reduce uterine size and CA125 levels compared to pharmacological medicine alone. It also improved dysmenorrheal symptoms after three months of treatment. Additionally, the incidence of adverse events, especially hot flashes, was lower in the acupuncture group. The study suggests that acupuncture holds promise as an alternative treatment for adenomyosis, but further rigorous trials are required to confirm these findings.

A Network Pharmacology published in 2021 in the journal Evidence-Based Complementary and Alternative Medicine found that Gui Zhi Fu Ling Wan treats adenomyosis by intervening in local estrogen signalling pathways and affecting estrogen resistance via myometrium signalling pathways. This study utilized network pharmacology, molecular docking and animal experiments to understand the treatment mechanisms of Guizhi Fuling Wan on adenomyosis. Initially, key indices and target components of the traditional Chinese medicine were identified through various databases, which resulted in isolation of 55 active ingredients and 44 targets specifically related to adenomyosis treatment. These components were then subjected to protein interaction analysis and compound-hub target network constructions. Main active elements and hub targets were subsequently studied with molecular docking tech. The pathway enrichment analysis showed that the medicinal effects were primarily linked to estrogen signaling, endocrine resistance, and a specific tyrosine kinase signaling pathway. The molecular docking revealed that significant compounds of Guizhi Fuling Wan had a strong binding ability with a couple of cellular receptors. Animal trials indicated that this medicine could reduce abnormal infiltration of specific cells without interrupting normal sexual cycles. These results point towards the importance of the estrogen signaling pathway and cell receptors in the treatment capabilities of Guizhi Fuling Wan.

A Systematic Review published in 2020 in the journal BioMed Research International found that Endometriosis and Adenomyosis can have impact on miscarriage risk in pregnancy. The study analyzed 39 publications involving 697,984 women to assess the impact of endometriosis (EMS) and adenomyosis (AD) on miscarriage risk. Women with EMS showed increased miscarriage risk in spontaneous conception (SC), but similar risk in assisted reproductive technology (ART) compared to tubal infertility. AD was associated with higher miscarriage risk in ART. Sensitivity analyses supported these conclusions. EMS staging did not significantly alter miscarriage risk. Early-stage EMS showed higher early abortion risk. No significant associations were found between EMS and low birthweight, placental abruption, intrauterine growth restriction, or preeclampsia. EMS correlated with higher odds of antepartum hemorrhage, postpartum hemorrhage, preterm birth, placenta praevia, and stillbirth. SUP and DIE were linked to increased miscarriage risk, while OMA showed no significant association. The findings suggest the need for closer monitoring and follow-up for pregnant women with EMS or AD, particularly in early pregnancy. Standardized recording of EMS types, stages, and miscarriage timing is recommended for future studies.

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