Dang Gui Shao Yao San

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Chinese Medicine Research Hub

Review Article

The widely-used herbal formula Dang Gui Shao Yao San can alleviate cognitive dysfunction in Alzheimer's disease by improving the function of various central nervous systems.

2015 Aging & Disease Danggui-Shaoyao-San: New Hope for Alzheimer's Disease
Fu X, Wang Q, Wang Z, Kuang H, Jiang P

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A Review Article published in 2015 in the journal Aging & Disease found that The widely-used herbal formula Dang Gui Shao Yao San can alleviate cognitive dysfunction in Alzheimer's disease by improving the function of various central nervous systems. The study examines the impact of the herbal formula Danggui-Shaoyao-San (DSS), commonly used for treating various gynecological conditions, on neurological disorders, particularly Alzheimer's disease. DSS has been observed to exert beneficial effects on the central monoamine neurotransmitter systems, improving the functionality of dopaminergic, adrenergic, and serotonergic nervous systems. Furthermore, it has shown a mitigating effect on the dysfunction of the central cholinergic nervous system and a scopolamine-induced decrease in Acetylcholine levels. In the discussion of results, it was discerned that DSS demonstrates anti-inflammatory and antioxidant activities, while also reducing cell apoptosis in the hippocampus. Additionally, it's suggested DSS could play a role in moderating free radical-mediated neurological diseases. Of major significance was the observation that DSS can potentially alleviate cognitive dysfunction in Alzheimer's patients, positioning it as a potentially effective treatment for this disease.

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