Bu Zhong Yi Qi Tang

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Chinese Medicine Research Hub

Randomised Controlled Trial

Using a combined treatment of modified Buzhong Yiqi decoction and Gangtai ointment improves wound healing and anal function for circumferential mixed hemorrhoid patients.

2021 American Journal of Translational Research The effects of modified Buzhong Yiqi decoction combined with Gangtai ointment on the wound healing and anal function in circumferential mixed hemorrhoid patients
Lu B, Du J, Wu X

Chinese Medicine Research Hub

Randomised Controlled Trial

The herbal medicine Bu Zhong Yi Qi Yang can potentially promote healing in chronic wounds resistant to standard treatments, especially in malnourished patients.

2019 Wound Repair and Regeneration The beneficial effect of traditional Japanese herbal (Kampo) medicine, Hochu‐ekki‐to (Bu‐Zhong‐Yi‐Qi‐Tang), for patients with chronic wounds refractory to conventional therapies: A prospective, randomized trial
Akita S, Namiki T, Kawasaki Y, Rikihisa N, Ogata H, Tokumoto H, Tezuka T, Kubota Y, Kuriyama M, Nakamura M, Mitsukawa N

Chinese Medicine Research Hub

Systematic Review

Bu Zhong Yi Qi Tang treatment improves clinical symptoms, exercise capacity, lung function and quality of life for patients with stable chronic obstructive pulmonary disease.

2016 Complementary Therapies in Medicine A systematic review and meta-analysis of the herbal formula Buzhong Yiqi Tang for stable chronic obstructive pulmonary disease
Yuanbin Chen, Johannah Linda Shergis, Lei Wu, Xuhua Yu, Qigang Zeng, Yinji Xu, Xinfeng Guo, Anthony Lin Zhang, Charlie Changli Xue, Lin Lin

Executive Summary

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A Randomised Controlled Trial published in 2021 in the journal American Journal of Translational Research found that Using a combined treatment of modified Buzhong Yiqi decoction and Gangtai ointment improves wound healing and anal function for circumferential mixed hemorrhoid patients. The researchers enrolled 120 patients with circumferential mixed hemorrhoids into this trial. After undergoing a surgical procedure, these participants were randomly sorted into two groups for treatment. The control group received chitosan hydrogels for wound healing on a daily basis. Meanwhile, the research group was treated with a daily oral dose of modified Buzhong Yiqi decoction together with Gangtai ointment applied externally twice a day for two weeks. Observations for comparison between groups included effective rates, pain indexes, perianal edema scores, quality of life score, wound healing and pain resolution times, anal functions, wound exudate scores, as well as adverse reactions. In comparing the results of the experiment, it was found that the modified Buzhong Yiqi and Gangtai ointment combination gave better results across most measured outcomes. The research group showed a higher effective rate, reduced pain, and less perianal edema. The group's quality of life was improved, and their wounds healed more quickly with less pain experienced during recovery. Being able to maintain anal function was found to be more successful in the research group, and they had fewer incidences of adverse reactions. Furthermore, changes in wound exudate scores at 7 and 14 days post-treatment were lesser than those observed in the control group.

A Randomised Controlled Trial published in 2019 in the journal Wound Repair and Regeneration found that The herbal medicine Bu Zhong Yi Qi Yang can potentially promote healing in chronic wounds resistant to standard treatments, especially in malnourished patients. In this investigation, a prospective, randomized trial was conducted on 18 patients with unresponsive chronic wounds. These patients were split into two groups: a medication group treated daily with 7.5g of oral Hochu-ekki-to, and a control group who didn't receive this treatment. The status of wound healing was assessed over a 12-week period, where it was scored based on factors such as depth, inflammation/infection, size, granulation tissue, necrotic tissue, exudate, and pocket size. In the study, all patients in the medication group showed progress in wound healing at the end of 12 weeks. Conversely, only three patients in the control group showed comparable progress. This marked healing in the medication group was significantly noticeable after the 8-week mark. Hence, the study concluded that Hochu-ekki-to can be considered a beneficial adjunct therapy in managing chronic wounds, especially for patients suffering from malnutrition.

A Systematic Review published in 2016 in the journal Complementary Therapies in Medicine found that Bu Zhong Yi Qi Tang treatment improves clinical symptoms, exercise capacity, lung function and quality of life for patients with stable chronic obstructive pulmonary disease. Methodology: The researchers performed a systematic review of three English databases (PubMed, EMBASE and CENTRAL) and four Chinese databases (CBM, CNKI, CQVIP and WFMO), with selection ending on 30th June 2016. Participants in the reviewed studies were diagnosed with chronic obstructive pulmonary disease according to recognized guidelines and were in a stable stage of the disease. Included were randomized controlled trials of oral Buzhong Yiqi Tang, whether alone or combined with conventional treatment, compared to conventional treatment alone or with a placebo. Various outcome measures were used to evaluate the efficacy of the treatment. Discussion of Results: Sixteen studies involving 1400 participants were included. In general, patients treated with Buzhong Yiqi Tang alone or in combination with conventional treatments showed significant improvement in their condition. This improvement was noted in areas such as clinical symptoms, exercise capacity, lung function, and quality of life compared to those on conventional treatment alone or with a placebo. The treatment also reduced the number of acute exacerbations of the disease. There were very few reported adverse events, inferring a good safety profile for this treatment regimen.

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