You Gui Wan
Recent Insights
The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
Ovarian Insufficiency Premature ovarian failure (POF) You Gui Wan
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
A Network Pharmacology Study on the Similarities and Differences in the Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of Premature Ovarian Failure
2022 Oct 18 Combinatorial Chemistry & High Throughput Screening Shanshan Mei, Chaoqin Yu, Jie Ding, Wen Cheng
Network Pharmacology Premature ovarian failure (POF) You Gui Wan Ovarian InsufficiencyThe Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
HPLC-MS/MS based comparative pharmacokinetics of 12 bioactive components in normal and osteoporosis rats after oral administration of You-Gui-Wan
2021 Dec 21 Journal of Separation Science Hua Yin, Yahong Wang, Ling Wang, Xue Bai, Jianhua Zhang
Thus, the optimized analytical method, along with the pharmacokinetic evaluation in the osteoporotic model may offer a more comprehensive understanding to elucidate the anti-osteoporosis mechanism of You-Gui-Wan. These findings may aid in developing a more effective treatment plan for osteoporosis.
Animal Study Osteoporosis You Gui Wan
An experimental research into the potential therapeutic effects of Anti-Osteoporosis Decoction and Yougui Pill on ovariectomy-induced osteoporosis
2019 Sep 15 American Journal of Translational Research Gu F, Jiang J, Wang S, Feng T, Zhou Y, Ma Y, et al.
In conclusion, Anti-Osteoporosis Decoction (AOD) and Yougui Pill (YGP) exert regulatory effects on osteoporosis in ovariectomized rats. They may be potential candidates for the therapy and cure of human osteoporosis.
Animal Study You Gui Wan Osteoporosis
Integrated Systems Pharmacology, Urinary Metabonomics, and Quantitative Real-Time PCR Analysis to Uncover Targets and Metabolic Pathways of the You-Gui Pill in Treating Kidney-Yang Deficiency Syndrome
2019 Jul 26 International Journal of Molecular Sciences Chen R, Wang J, Zhan R, Zhang L, Wang X
The mechanism of action mainly involved energy metabolism, oxidative stress, ammonia metabolism, amino acid metabolism, and fatty acid metabolism. In short, our study demonstrated that targets and metabolic pathways for the treatment of KYDS by YGP can be effectively found via combining with systems pharmacology and urinary metabonomics. In addition to this, common and specific targets and metabolic pathways of KYDS treated by YGP can be found effectively by integration with the analysis of different biological samples (e.g., serum, urine, feces, and tissue). It is; therefore, important that this laid the foundation for deeper mechanism research and drug-targeted therapy of KYDS in future.
Network Pharmacology You Gui Wan Kidney-Yang Deficiency
Effect of Zuogui pill and Yougui pill on osteoporosis: a randomized controlled trial
2018 Feb Journal of Traditional and Complementary Medicine Wenxiong L, Kuaiqiang Z, Zhu L, Li L, Yan C, Jichao Y, et al.
Zuogui pill or Yougui pill could improve bone mineral density (BMD), ease pain, relieve Kidney deficiency syndrome, improve the quality of life osteoporosis patients, inhibit bone conversion and regulate the coupling balance of bone formation and bone resorption.
Randomised Controlled Trial You Gui WanResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
2022 Combinatorial Chemistry & High Throughput Screening A Network Pharmacology Study on the Similarities and Differences in the Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of Premature Ovarian Failure Shanshan Mei, Chaoqin Yu, Jie Ding, Wen Cheng
Network Pharmacology Ovarian Insufficiency Premature ovarian failure (POF)
This study used a public database to identify the active ingredients and potential targets of the Zuo Gui Wan and You Gui Wan compounds. These were analyzed in relation to premature ovarian failure (POF) related genes obtained from OMIM and GeneCards. A protein-protein interaction network was established using STRING, and a drug-active ingredient-target gene network was constructed. The study thus identified similarities and differences in potential targets, active ingredients, and enriched pathways between the two compounds.
Analyzing the drug-target-pathway network revealed that both compounds contain multiple common active ingredients, as well as unique components, and share several targets in the treatment of POF, showing similar core mechanisms of action. However, each compound also targets some unique pathways, which indicates their differential approaches to POF treatment.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
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The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
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