Suan Zao Ren
Also known as: Jujube Seed
Recent Insights
The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
GABA Jujube Sleep
Consumption of jujube seed had a positive impact on improving the sleep quality of postmenopausal women and could be recommended as a useful herbal medication.
Jujube Sleep Suan Zao Ren
Jujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
Anxiety GABA system Serotonin
The study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba.
Anti-Ageing Anti-Inflammatory Anticancer
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Sleep-Enhancing Effect of Water Extract from Jujube (Zizyphus jujuba Mill.) Seeds Fermented by Lactobacillus brevis L32
2023 Jul 27 Foods Bae GY, Ahn Y, Hong KB, Jung EJ, Suh HJ, Jo K
Experimental Study GABA Jujube Suan Zao Ren SleepThe fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
Investigation the effect of jujube seed capsule on sleep quality of postmenopausal women: A double-blind randomized clinical trial
2020 Dec 1 BioMedicine Mahmoudi R, Ansari S, Haghighizadeh MH, Maram NS, Montazeri S.
Randomised Controlled Trial Sleep Jujube Suan Zao RenConsumption of jujube seed had a positive impact on improving the sleep quality of postmenopausal women and could be recommended as a useful herbal medication.
Regulation of GABAA and 5-HT Receptors Involved in Anxiolytic Mechanisms of Jujube Seed: A System Biology Study Assisted by UPLC-Q-TOF/MS and RT-qPCR Method
2020 Oct 15 Frontiers in Pharmacology Chen L, Zhang X, Hu C, Zhang Y, Zhang L, Kan J, et al.
Experimental Study Anxiety GABA system Suan Zao Ren SerotoninJujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review
2020 Jul 10 Evidence-Based Complementary and Alternative Medicine Su-Rong He, Chong-Bo Zhao, Jing-Xia Zhang, Jing Wang, Bo Wu, Chun-Jie Wu, et al.
Systematic Review Anti-Inflammatory Antioxidant Jujube Anti-Ageing Suan Zao Ren Anticancer High Blood Pressure Cognitive FunctionThe study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba.
Targets and underlying mechanisms related to the sedative and hypnotic activities of saponin extracts from semen Ziziphus jujube
2020 Jan Food & Function Shen CY, Wan L, Zhu JJ, Jiang JG
Both SZJ-I and SZJ-II demonstrated significant sedative-hypnotic activities, as evidenced by shortened immobility time and potentiation of sodium pentobarbital-induced sleep. SZJ-II, with a higher saponin content, exhibited greater potency. SZJ-I and SZJ-II also protected against PCPA-induced neuropathological damages in the brain and modulated neurotransmitter levels (5-HT, dopamine, noradrenaline, glutamate), inflammatory markers (IL-6, IL-1β), and other signaling molecules (nitric oxide, prostaglandin D2) in plasma. Furthermore, SZJ-I and SZJ-II differentially regulated the expression of various receptors and enzymes in the hypothalamus and hippocampus, suggesting multiple mechanisms contributing to their sedative-hypnotic effects.
Experimental Study Animal Study Suan Zao RenResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
2023 Foods Sleep-Enhancing Effect of Water Extract from Jujube (Zizyphus jujuba Mill.) Seeds Fermented by Lactobacillus brevis L32 Bae GY, Ahn Y, Hong KB, Jung EJ, Suh HJ, Jo K
Experimental Study GABA Jujube Sleep
Methodology: An aqueous extract of jujube seeds (ZW) was fermented, following a starch-removing enzymatic degradation process, to increase its γ-aminobutyric acid (GABA) content, resulting in a fermented product (ZW-FM). The sleep-promoting effect of ZW-FM was evaluated using rodent models; specifically, sleep tests were performed on ICR mice with pentobarbital-induced sleep, while the electroencephalography analysis was undertaken in Sprague Dawley rats. Awakening relief effects of ZW-FM were assessed using a caffeine-induced insomnia model. To understand the mechanism, GABA receptor type A (GABA) antagonists were used.
Results: The groups given ZW-FM treatment displayed a longer sleep duration, particularly increased δ-wave time during non-rapid eye movement sleep, and reduced sleep latency. Particularly, the model treated with ZW-FM showed an increase in non-rapid-eye-movement sleep and a reduction in the REM sleep duration, brought about by caffeine treatment. The enhanced sleep induction caused by ZW-FM was hindered by GABA receptor antagonists, thereby validating the involvement of a GABAergic mechanism in promoting sleep.
Consumption of jujube seed had a positive impact on improving the sleep quality of postmenopausal women and could be recommended as a useful herbal medication.
2020 BioMedicine Investigation the effect of jujube seed capsule on sleep quality of postmenopausal women: A double-blind randomized clinical trial Mahmoudi R, Ansari S, Haghighizadeh MH, Maram NS, Montazeri S.
Randomised Controlled Trial Jujube Sleep
The results show that the medicinal jujube seed capsule improved the sleep quality of postmenopausal women. Thus, it could be recommended as a safe plant with fewer complications compared to chemical and hormone drugs for the treatment of sleep disorders. Also, during the period of consuming jujube seed capsule in this study, except for a few cases of gastrointestinal disorders and in similar studies with this herbal medicine, consumers have reported no specific side effects. Therefore, considering that about one-third of adults in the world suffer from sleep disorders, the high prevalence of sleep disorders in postmenopausal women, and the lower cost of treatment by jujube seed capsule compared to other treatments, it is suggested implementing this treatment as a useful method in improving sleep quality in postmenopausal women.
Jujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
2020 Frontiers in Pharmacology Regulation of GABAA and 5-HT Receptors Involved in Anxiolytic Mechanisms of Jujube Seed: A System Biology Study Assisted by UPLC-Q-TOF/MS and RT-qPCR Method Chen L, Zhang X, Hu C, Zhang Y, Zhang L, Kan J, et al.
Experimental Study Anxiety GABA system Serotonin
The research relied on a system biology method supported by Ultra Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry (UPLC-Q-TOF/MS) and Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR). Initially, 35 phytochemicals were identified from the Jujube seed extract, which related to 71 anxiolytic targets. Further investigations, including protein-protein interaction, gene cluster, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analyses, were conducted to identify the anxiolytic mechanisms of the extract.
The results highlighted that the main anxiolytic mechanisms of the Jujube seed extract were linked to the regulation of serotonergic and GABAergic synapse pathways. The extract's impact on the mRNA expressions of multiple gamma-aminobutyric acid type A (GABA) and serotonin (5-HT) receptors subtypes was verified in human neuroblastoma cells. Surprisingly, the extract (250 μg/mL) not only amplified the mRNA level of GABRA1 and GABRA3 alongside HTR1A, HTR2A, and HTR2B in untreated cells but also suppressed the overexpressed mRNA of GABRA1, GABRA2, HTR1A, and HTR2A in stress-induced cells.
The study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba.
2020 Evidence-Based Complementary and Alternative Medicine Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review Su-Rong He, Chong-Bo Zhao, Jing-Xia Zhang, Jing Wang, Bo Wu, Chun-Jie Wu, et al.
Systematic Review Anti-Ageing Anti-Inflammatory Anticancer
The methodology of the research was primarily a comprehensive literature review of Ziziphi Spinosae Semen (aka Suan Zao Ren). The team explored the botanical characteristics, traditional uses, pharmacology, and discovered compounds in the seeds of Ziziphus Jujuba.
In regards to the results of the review, more than 150 compounds were identified in Ziziphi Spinosae Semen. These compounds, which mainly include terpenoids, flavonoids and others, show various biological activities. It was found that the seeds are particularly prominent in having sedative and hypnotic effects. Other properties discovered include antitumor potential, improvement to learning and memory, anti-inflammatory, antioxidative, anti-aging, alongside lower blood pressure and lipid levels. Traditional usage of the seeds for the treatment of insomnia, forgetfulness, headaches and dizziness were confirmed by the review.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review
2020 Jul 10 Evidence-Based Complementary and Alternative Medicine Su-Rong He, Chong-Bo Zhao, Jing-Xia Zhang, Jing Wang, Bo Wu, Chun-Jie Wu, et al.
Systematic Review Anti-Inflammatory Antioxidant Jujube Anti-Ageing Suan Zao Ren Anticancer High Blood Pressure Cognitive FunctionThe study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba.
Traditional Use of Chinese Herbal Medicine for Insomnia and Priorities Setting of Future Clinical Research
2019 Jan The Journal of Alternative and Complementary Medicine Ni X, Shergis JL, Zhang AL, Guo X, Lu C, Li Y, et al.
A number of herbal formulae for insomnia were cited in the historical literature. The commonly cited formulae such as Wen dan tang and Suan zao ren tang are consistent with current clinical practice and are good prospects for further therapeutic development.
Systematic Review Suan Zao Ren Suan Zao Ren Tang Gui Pi Tang Wen Dan Tang InsomniaClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Presentation Slides
The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
Consumption of jujube seed had a positive impact on improving the sleep quality of postmenopausal women and could be recommended as a useful herbal medication.
Jujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
The study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba.
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