ST36
Also known as: Zu San Li, Zusanli
Recent Insights
ST36 acupoint injections with dexamethasone outperforms conventional western medicine in treating chemotherapy-induced myelosuppression, significantly improving clinical efficacy and recovery.
ST36
Acupuncture at Zusanli (ST36) might be effective in reducing injuries induced by sepsis in various organs by reducing oxidative stress and inflammation.
ST36
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Brain Activities Responding to Acupuncture at ST36 (zusanli) in Healthy Subjects: A Systematic Review and Meta-Analysis of Task-Based fMRI Studies
2022 Jul 22 Frontiers in Neurology Huang H, Yue X, Huang X, Long W, Kang S, Rao Y, et al.
Acupuncture at ST36 in healthy individuals positively activates the opercular part of right inferior frontal gyrus (IFG.R), left superior temporal gyrus (STG.L), and right median cingulate/paracingulate gyri (MCG.R). The left olfactory cortex may exhibit positive needle retention time-dependent activities.
Systematic Review Meta-Analysis
Efficacy of Press Needle at PC6 Neiguan and ST36 Zusanli as Adjuvant Therapy in Reducing Symptoms of Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients Undergoing Chemotherapy
2022 Apr 01 Medical Acupuncture Bintoro DA, Nareswari I, Andriastuti M
Press needle acupuncture is able to reduce the Rhodes index of nausea, vomiting, and retching (RINVR) score and can be applied to pediatric patients because of its minimal side effects, but further research is needed to determine the appropriate treatment time.
Randomised Controlled Trial Chemotherapy-Induced Nausea and Vomiting Vomiting Nausea
Anti-Inflammatory Effects of Acupuncture at ST36 Point: A Literature Review in Animal Studies
2022 Jan 12 Frontiers in Immunology Oh JE, Kim SN
ST36 has clinical benefits in relieving inflammation through several mechanisms such as vagus nerve activation, toll-like receptor 4 (TLR4)/NF-κB signaling, macrophage polarization, mitogen-activated protein kinase (MAPK) signaling pathway, and cholinergic anti-inflammatory pathway.
Animal Study Review Article
The effect of acupuncture and selection of acupoints on myelosuppression after chemotherapy
2022 Jan TMR Non-Drug Therapy Wang XZ, Zhang XY, Zhang YN, Xia L
Acupuncture significantly inhibited the decline in blood cell components (white blood cell count, platelet count, red blood cell count, and hemoglobin) except for neutrophils in patients with myelosuppression after chemotherapy. Acupoints, mainly from the bladder meridian, stomach meridian, and spleen meridian, were distributed in the limbs and back. Specific points such as ST36 and SP6 were frequently used, with ST36-SP6-RN6-SP10-RN4 identified as a central combination in acupuncture prescriptions for this population.
Systematic Review Meta-Analysis Acupuncture Myelosuppression
Efficacy and Safety of Acupuncture with Western Medicine for Rheumatoid Arthritis: A Systematic Review and Meta-analysis
2021 Aug 24 Acupuncture & Electro-Therapeutics Research Huo X, Liang L, Ding X, Bihazi A, Xu H
Systematic Review Meta-AnalysisTreatment of rheumatoid arthritis using acupuncture with Western medicine was associated with higher efficacy and lower risks than treatment with Western medicine alone.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Treatment of rheumatoid arthritis using acupuncture with Western medicine was associated with higher efficacy and lower risks than treatment with Western medicine alone.
2021 Acupuncture & Electro-Therapeutics Research Efficacy and Safety of Acupuncture with Western Medicine for Rheumatoid Arthritis: A Systematic Review and Meta-analysis Huo X, Liang L, Ding X, Bihazi A, Xu H
Systematic Review
In total, 9 RCTs involving 698 patients were included for analysis. VAS, ESR, CRP, and RF were all shown to favor the combination of acupuncture with Western medicine compared to Western medicine alone. ST36 (Zusanli), EX-UE9 (Baxie), Ll11 (Quchi), GB34 (Yanglingquan), TE14 (Jianliao) and TE4 (Yangchi) were frequently used in 9 clinical trials.
ST36 acupoint injections with dexamethasone outperforms conventional western medicine in treating chemotherapy-induced myelosuppression, significantly improving clinical efficacy and recovery.
2021 Frontiers in Oncology Zusanli (ST36) Acupoint Injection With Dexamethasone for Chemotherapy-Induced Myelosuppression: A Systematic Review and Meta-Analysis Chen J, Lin Z, Ding J
Systematic Review
The study executed a systematic evaluation of the efficacy of ST36 acupoint injection with dexamethasone in treating chemotherapy-induced myelosuppression. A total of 17 randomized controlled trials from eight different databases were extracted for this meta-analysis. A detailed examination and analysis of various data gathered were performed using the Cochrane Collaboration tool for bias, Excel 2010 for creating an information extraction database, and RevMan 5.3.0 software for analyzing test data. The quality of evidence was graded using GRADE profiler 3.6 software.
The results indicated that compared to conventional western medicine, ST36 acupoint injection with dexamethasone vastly improved the clinical aggregate effective rate. Notably, it increased the white blood cell count and hemoglobin levels in patients, further enhancing their Karnofsky performance status. The treatment also shortened the recovery time of myelosuppression. However, there were no significant differences observed in platelet elevation between the ST36 acupoint injection with dexamethasone and conventional western medicine.
Acupuncture at Zusanli (ST36) might be effective in reducing injuries induced by sepsis in various organs by reducing oxidative stress and inflammation.
2020 Evidence-Based Complementary and Alternative Medicine Acupuncture at Zusanli (ST36) for Experimental Sepsis: A Systematic Review Lai F, Ren Y, Lai C, Chen R, Yin X, Tan C, et al.
Systematic Review
The researchers conducted a systematic review of seven databases, covering the inception of each to May 2019. They identified 54 studies that used acupuncture at ST36, a specific acupuncture point, for treating experimental sepsis, drawing from both English and Chinese literature resources.
The studies reviewed suggest that acupuncture could serve as a complementary strategy in treating sepsis by reducing damage in multiple body systems: cardiac, lung, kidney, liver, gastrointestinal tract, and the immune system. It's thought to achieve these results through several mechanisms: limiting oxidative stress, managing inflammation, improving microcirculation, and upholding immune balance with the help of dopamine. Worth noting, however, is that these positive findings must be carefully considered due to the methodological quality and potential publication bias of the included studies.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Brain Activities Responding to Acupuncture at ST36 (zusanli) in Healthy Subjects: A Systematic Review and Meta-Analysis of Task-Based fMRI Studies
2022 Jul 22 Frontiers in Neurology Huang H, Yue X, Huang X, Long W, Kang S, Rao Y, et al.
Acupuncture at ST36 in healthy individuals positively activates the opercular part of right inferior frontal gyrus (IFG.R), left superior temporal gyrus (STG.L), and right median cingulate/paracingulate gyri (MCG.R). The left olfactory cortex may exhibit positive needle retention time-dependent activities.
Systematic Review Meta-AnalysisAnti-Inflammatory Effects of Acupuncture at ST36 Point: A Literature Review in Animal Studies
2022 Jan 12 Frontiers in Immunology Oh JE, Kim SN
ST36 has clinical benefits in relieving inflammation through several mechanisms such as vagus nerve activation, toll-like receptor 4 (TLR4)/NF-κB signaling, macrophage polarization, mitogen-activated protein kinase (MAPK) signaling pathway, and cholinergic anti-inflammatory pathway.
Animal Study Review ArticleThe effect of acupuncture and selection of acupoints on myelosuppression after chemotherapy
2022 Jan TMR Non-Drug Therapy Wang XZ, Zhang XY, Zhang YN, Xia L
Acupuncture significantly inhibited the decline in blood cell components (white blood cell count, platelet count, red blood cell count, and hemoglobin) except for neutrophils in patients with myelosuppression after chemotherapy. Acupoints, mainly from the bladder meridian, stomach meridian, and spleen meridian, were distributed in the limbs and back. Specific points such as ST36 and SP6 were frequently used, with ST36-SP6-RN6-SP10-RN4 identified as a central combination in acupuncture prescriptions for this population.
Systematic Review Meta-Analysis Acupuncture MyelosuppressionEfficacy and Safety of Acupuncture with Western Medicine for Rheumatoid Arthritis: A Systematic Review and Meta-analysis
2021 Aug 24 Acupuncture & Electro-Therapeutics Research Huo X, Liang L, Ding X, Bihazi A, Xu H
Systematic Review Meta-AnalysisTreatment of rheumatoid arthritis using acupuncture with Western medicine was associated with higher efficacy and lower risks than treatment with Western medicine alone.
Zusanli (ST36) Acupoint Injection With Dexamethasone for Chemotherapy-Induced Myelosuppression: A Systematic Review and Meta-Analysis
2021 Jul 06 Frontiers in Oncology Chen J, Lin Z, Ding J
Systematic Review Meta-Analysis ST36ST36 acupoint injections with dexamethasone outperforms conventional western medicine in treating chemotherapy-induced myelosuppression, significantly improving clinical efficacy and recovery.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Efficacy of Press Needle at PC6 Neiguan and ST36 Zusanli as Adjuvant Therapy in Reducing Symptoms of Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients Undergoing Chemotherapy
2022 Apr 01 Medical Acupuncture Bintoro DA, Nareswari I, Andriastuti M
Press needle acupuncture is able to reduce the Rhodes index of nausea, vomiting, and retching (RINVR) score and can be applied to pediatric patients because of its minimal side effects, but further research is needed to determine the appropriate treatment time.
Randomised Controlled Trial Chemotherapy-Induced Nausea and Vomiting Vomiting NauseaAcupuncture and Related Therapies for Treatment of Postoperative Ileus in Colorectal Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
2018 Jul 29 Evidence-Based Complementary and Alternative Medicine Liu, Y., May, B. H., Zhang, A. L., et al.
The addition of an acupuncture intervention following surgery for colorectal cancer improved outcomes for recovery of gastrointestinal function based on pooled data from four blinded good quality RCTs (281 participants) and 17 nonblinded lower quality RCTs (1,265 participants). The best available evidence was for interventions that included electroacupuncture at ST36 Zusanli (with or without other points). There is also supporting evidence for other types of acupuncture therapies (manual acupuncture, acupressure, warming needling, etc.) that involve stimulation of this point. Further well-designed blinded studies are needed to confirm these findings and determine optimal acupuncture interventions for postoperative ileus.
Systematic Review Randomised Controlled Trial Postoperative Ileus Postoperative Care Colorectal Cancer
Effects of Electroacupuncture Administered 24 hours Prior to Surgery on Postoperative Nausea and Vomiting and Pain in Patients Undergoing Gynecologic Laparoscopic Surgery: A Feasibility Study
2017 Sep Explore: The Journal of Science & Healing Li S, Zheng M, Wu W, Guo J, Ji F, Zheng Z
In a randomized controlled trial with 40 patients, EA was delivered at bilateral neiguan (PC6) and zusanli (ST36) points within 24 hours prior to surgery. The EA group exhibited a lower incidence of postoperative nausea and vomiting in the first six hours compared to the usual care (UC) group. Postoperative pain was significantly lower in the EA group at six hours postoperative, and the EA group had a shorter time to pass the first flatus compared to the UC group. Adverse effects of EA were minor and well-tolerated. The study suggests that one-session preoperative EA is feasible, safe, and may reduce postoperative pain and accelerate gastrointestinal motility.
Randomised Controlled TrialPresentation Slides
Treatment of rheumatoid arthritis using acupuncture with Western medicine was associated with higher efficacy and lower risks than treatment with Western medicine alone.
ST36 acupoint injections with dexamethasone outperforms conventional western medicine in treating chemotherapy-induced myelosuppression, significantly improving clinical efficacy and recovery.
Acupuncture at Zusanli (ST36) might be effective in reducing injuries induced by sepsis in various organs by reducing oxidative stress and inflammation.
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