Renal Fibrosis
Recent Insights
Jian-Pi-Yi-Shen formula has shown potential in delaying kidney deterioration in chronic kidney disease by rejuvenating the process of creating nicotinamide adenine dinucleotide.
Chronic Kidney Disease Jian Pi Yi Shen Formula Renal Fibrosis
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Jian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis in vivo and in vitro
2023 Dec 28 Aging Gao L, Huang X, Deng R, Wu S, Peng Y, Xiong G, et al.
Experimental Study Animal Study Renal Fibrosis Jian Pi Yi Shen Formula Chronic Kidney DiseaseJian-Pi-Yi-Shen formula has shown potential in delaying kidney deterioration in chronic kidney disease by rejuvenating the process of creating nicotinamide adenine dinucleotide.
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics
2023 Jan Phytomedicine Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, et al.
Zhen Wu Decoction (ZWD) maintains mitochondrial integrity and improves oxidative phosphorylation (OXPHOS) which represents an innovative insight into “strengthening Yang-Qi” theory. ZWD limits tubular fibrogenesis by reinvigorating tubular bioenergetic capacity.
Animal Study Zhen Wu Decoction
Plant flavonoids bioavailability in vivo and mechanisms of benefits on chronic kidney disease: a comprehensive review
2022 Sep 22 Phytochemistry Reviews Lin Y, Fang J, Zhang Z, Farag MA, Li Z, Shao P
Plant flavonoids exhibit an alleviating effect on CKD through various mechanisms, including the reduction of oxidative stress, immune modulation, anti-inflammation, inhibition of renal fibrosis, anti-apoptosis, and regulation of gut flora. The study explores how plant flavonoids contribute to the improvement of renal health in CKD patients by regulating the intestinal flora through the gut-kidney axis. Additionally, the review introduces the products and development prospects of plant flavonoids in the context of CKD.
Review Article Cucumber Chronic Kidney Disease
Tetramethylpyrazine: An Active Ingredient of Chinese Herbal Medicine With Therapeutic Potential in Acute Kidney Injury and Renal Fibrosis
2022 Jan 25 Frontiers in Pharmacology Li J, Gong X
The study concludes that TMP may effectively prevent AKI by reducing oxidative stress injury, inhibiting inflammation, preventing apoptosis of intrinsic renal cells, and regulating autophagy. Additionally, TMP shows potential in impeding the progression of CKD through its anti-renal fibrosis effects.
Review Article Renal Fibrosis Tetramethylpyrazine Acute Kidney Injury Chuan XiongDeciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo
2020 Apr 15 Frontiers in Pharmacology Zhou S, Ai Z, Li W, You P, Wu C, Li L, et al.
This study identified the potential ingredients of the n-butanol extract of Taohe-Chengqi decoction (NE-THCQ) by UPLC-Q/TOF-MS/MS and explained the possible mechanisms of NE-THCQ against renal fibrosis by integrating network pharmacology and experimental validation.
Network Pharmacology Renal Fibrosis Tao He Cheng Qi DecoctionResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Jian-Pi-Yi-Shen formula has shown potential in delaying kidney deterioration in chronic kidney disease by rejuvenating the process of creating nicotinamide adenine dinucleotide.
2023 Aging Jian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis in vivo and in vitro Gao L, Huang X, Deng R, Wu S, Peng Y, Xiong G, et al.
Experimental Study Chronic Kidney Disease Jian Pi Yi Shen Formula
The study was conducted utilizing an adenine-diet feeding model for inducing chronic kidney disease in a breed of mice. For 4 weeks, these mice were given Jian-Pi-Yi-Shen formula orally. Human proximal tubular epithelial cells were stimulated with a growth factor, with or without the formula. Assessments were made of renal function via serum creatinine and blood urea nitrogen levels, with renal histopathological changes evaluated through specific staining techniques. Further, cell viability and NAD+ concentrations were monitored with assay kits.
The Jian-Pi-Yi-Shen formula did not only help in the improvement of renal function and reduction of pathological injury but it also inhibited renal fibrosis in the mice with chronic kidney disease. Moreover, the same formula was found to reverse fibrotic responses induced by a growth factor in human proximal tubular epithelial cells. Importantly, the formula was observed to recover the decreased NAD+ content in the chronic kidney disease mice and the human cells, bringing about the restoration of the expression of vital enzymes in the NAD+ synthesis process.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Plant flavonoids bioavailability in vivo and mechanisms of benefits on chronic kidney disease: a comprehensive review
2022 Sep 22 Phytochemistry Reviews Lin Y, Fang J, Zhang Z, Farag MA, Li Z, Shao P
Plant flavonoids exhibit an alleviating effect on CKD through various mechanisms, including the reduction of oxidative stress, immune modulation, anti-inflammation, inhibition of renal fibrosis, anti-apoptosis, and regulation of gut flora. The study explores how plant flavonoids contribute to the improvement of renal health in CKD patients by regulating the intestinal flora through the gut-kidney axis. Additionally, the review introduces the products and development prospects of plant flavonoids in the context of CKD.
Review Article Cucumber Chronic Kidney DiseaseTetramethylpyrazine: An Active Ingredient of Chinese Herbal Medicine With Therapeutic Potential in Acute Kidney Injury and Renal Fibrosis
2022 Jan 25 Frontiers in Pharmacology Li J, Gong X
The study concludes that TMP may effectively prevent AKI by reducing oxidative stress injury, inhibiting inflammation, preventing apoptosis of intrinsic renal cells, and regulating autophagy. Additionally, TMP shows potential in impeding the progression of CKD through its anti-renal fibrosis effects.
Review Article Renal Fibrosis Tetramethylpyrazine Acute Kidney Injury Chuan XiongPresentation Slides
Jian-Pi-Yi-Shen formula has shown potential in delaying kidney deterioration in chronic kidney disease by rejuvenating the process of creating nicotinamide adenine dinucleotide.
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