Dang Gui Si Ni Decoction

Presentation Slides

Chinese Medicine Research Hub

Network Pharmacology

The Danggui Sini Decoction, a Traditional Chinese Medicine, may prevent myocardial infarction by positively influencing cell proliferation, inflammatory responses, and aging processes.

2024 Medicine Exploring the mechanism of Danggui Sini Decoction in the treatment of myocardial infarction: A systematic review, network pharmacology, and molecular docking
Li Z, Liu S, Zhang R, Li B

Chinese Medicine Research Hub

Network Pharmacology

Dang Gui Si Ni formula moderates intervertebral disc degeneration by primarily interacting with stress responses and apoptotic signaling pathways.

2021 BioMed Research International Pharmacological Mechanism of Danggui-Sini Formula for Intervertebral Disc Degeneration: A Network Pharmacology Study
Wang L, Lin J, Li W

Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Dang Gui Si Ni Decoction" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

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A Network Pharmacology published in 2024 in the journal Medicine found that The Danggui Sini Decoction, a Traditional Chinese Medicine, may prevent myocardial infarction by positively influencing cell proliferation, inflammatory responses, and aging processes. The researchers utilized network pharmacology and molecular docking to uncover the main components and targets of Danggui Sini Decoction (DSD) in the treatment of myocardial infarction. They examined myocardial infarction-related genes using the Genecards database and screened the active ingredients of DSD based on criteria relating to oral bioavailability and drug likeness. To understand the relationship between these components and their potential targets, the researchers generated a protein-protein interaction network diagram using the STRING database. Findings of the investigation led to the identification of 120 primary active ingredients and 561 putative active target genes. The main therapeutic targets were a number of genes associated with processes such as inflammation and cell proliferation. Furthermore, the researchers conducted gene ontology and Kyoto encyclopedia of gene and genome analyses to understand the pathways that DSD acts upon in treating myocardial infarction. The results indicated that DSD treatment involves the positive regulation of certain cellular cascades signifying positive impact on cell proliferation, inflammatory responses, aging, and other biological processes. Molecular docking results indicate potential interactions between DSD and certain genes, suggesting its role in treatment.

A Network Pharmacology published in 2021 in the journal BioMed Research International found that Dang Gui Si Ni formula moderates intervertebral disc degeneration by primarily interacting with stress responses and apoptotic signaling pathways. The study used traditional Chinese medicine SP (TCMSP), UniProt, and five disease gene databases to identify a gene set possibly responsive to DSF treatment of IVDD. In order to establish a protein interaction network involving DSF and IVDD, the STRING database was used. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the R platform, in order to deduce potential mechanisms. Molecular docking including the calculation of binding energy, was validated with AutoDock Vina. Subsequent to the identification of 119 active ingredients and 136 shared genes, the study reveals 10 core genes that are involved. Enrichment analysis signposts that DSF's therapeutic targets are primary focusses on certain signaling pathways relating to diabetic complications, Interleukin (IL)-17, Tumor Necrosis Factor (TNF), Toll-like receptor, apoptosis, cellular senescence, PI3K-Akt, and FoxO. Reactive oxygen species and stress responses as well as the controlling of apoptotic signalling pathways are the main biological processes these focus on. A stable affinity between the key components and the core genes was shown by molecular docking. Overall, the study used a combination of network pharmacology and molecular docking to affirm the multi-target and multi-pathway attributes of DSF for IVDD treatment.

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