Dang Shen
Also known as: Radix Codonopsis
Recent Insights
Zhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties.
Dang Shen Ge Gen Goji Berry
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Protective effect of ZYMT, a traditional Chinese patent medicine in a mouse model of retinitis pigmentosa
2023 Jun Biomedicine & Pharmacotherapy Huang Z, Huang Q, Xu K, Liang L, Li Y, Zhou W, et al.
Experimental Study Animal Study Dang Shen Shu Di Huang Huang Qi Ge Gen Goji Berry Zhang Yan Ming Tablets Retinitis PigmentosaZhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties.
Network pharmacology unveils spleen-fortifying effect of Codonopsis Radix on different gastric diseases based on theory of “same treatment for different diseases” in traditional Chinese medicine
2021 Apr Chinese Herbal Medicines He R, Jin Z, Ma R, Hu F, Dai J
Dangshen achieves spleen-fortifying effect on gastric diseases including gastric ulcer, gastritis and gastric cancer through multiple targets in multiple pathways, especially PI3K-AKT pathway and HIF-1 pathway. It could provide a scientific basis for understanding the strategy of “Same treatment for different diseases” in traditional Chinese medicine.
Network Pharmacology Dang Shen Gastric Diseases
Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial
2019 Dec 13 Phytotherapy Research Shin YK, Hsieh YS, Han AY, Lee KW, Seol GH
In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.
Randomised Controlled Trial High Blood Pressure Dang ShenResearch Insights
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Zhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties.
2023 Biomedicine & Pharmacotherapy Protective effect of ZYMT, a traditional Chinese patent medicine in a mouse model of retinitis pigmentosa Huang Z, Huang Q, Xu K, Liang L, Li Y, Zhou W, et al.
Experimental Study Ge Gen Goji Berry Huang Qi
Eighty mice with Retinitis Pigmentosa (RP) were divided into two groups, with one group receiving Zhangyanming Tablets (ZYMT) and a control group getting distilled water. After a period of 7 and 14 days, the researchers conducted tests through electroretinogram, fundus photography, and histological examination to assess the retinal function and structure of the subjects. They furthered the study using TUNEL, immunofluorescence and qPCR to evaluate cell apoptosis and the expressions of particular genes.
The ZYMT-treated mice displayed a notable enhancement in retinal reactions and overall preservation of retinal structure when compared to the control group. Particularly noticeable were increases in retinal thickness and cell count, alongside a significantly lowered rate of cell death. A comprehensive follow-up shows the altered expressions of several genes in the retina following the application of ZYMT. These results, combined, suggest a key role of ZYMT in mitigating the effects of RP especially in early stages.
Clinical Trials
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Zhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties.
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Zhangyanming Tablets (ZYMT) has been in clinical use for almost 4 decades. The main components of this medicine include Fructus Lycii (wolfberry), Radix Codonopsis, Radix Astragali, Radix Puerariae Lobatae, Radix Rehmanniae Praeparata and so on. —Jinnan C 25 Apr 2024