Antifungal
Recent Insights
Fennel exhibits antifungal, antibacterial, antioxidant, antithrombotic and hepatoprotective activities.
Antifungal Antioxidant Fennel Seed
The bioactive compounds in Chrysanthemums can be used to develop next generation, multi-functional drugs for various diseases including diabetes and prostate cancer.
Anti-Inflammatory Antibacterial Antifungal
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Chemical Properties and Biological Activity of Bee Pollen
2023 Nov 25 Molecules Rodríguez-Pólit C, Gonzalez-Pastor R, Heredia-Moya J, Carrera-Pacheco SE, Castillo-Solis F, Vallejo-Imbaquingo R, et al.
Review ArticleBee pollen showcases a range of biological activities, such as anti-inflammatory, antimicrobial, and potential antiviral properties, which could contribute to the creation of innovative therapies.
New tocopherol and acylphloroglucinol derivatives from Dryopteris crassirhizoma and their antimicrobial activities
2023 Mar Fitoterapia Hai P, He Y, Wang R, Gao Y, Wu X, Chen X, et al.
When combined with fluconazole (FLC), compound 3 showed significant antifungal activity against standard Candida albicans. Furthermore, the anti-plant pathogenic fungi and bacterial activities have been evaluated in vitro, compounds 5 and 8 showed anti-Verticillium dahlia and Sclerotinia sclerotiorum with MIC value and compounds 1 and 5 exhibited moderate antibacterial activities against Micrococcus luteus.
Network Pharmacology Guan Zhong Antimicrobial
Isolation of essential oil from Mosla chinensis Maxim by surfactant-enzyme pretreatment in high-solid system and evaluation of its biological activity
2022 Dec Industrial Crops and Products Li Z, Wang H, Wang F, Li H, Cao F, Luo D, et al.
The inhibitory enzyme activity and antifungal activity of M. chinensis EO were evaluated, the results indicated that EO had no obvious inhibitory activity on α-amylase and acetylcholinesterase, but had spectral antifungal activity. In general, the SEHS-MHD developed in this work is a potential and powerful alternative to traditional techniques for the sufficient isolation of EO from natural plant and crop materials.
Network Pharmacology Xiang Ru
Research Note: Study on the antibacterial activity of Chinese herbal medicine against Aspergillus flavus and Aspergillus fumigatus of duck origin in laying hens
2022 May Poultry Science Xue W, Li Y, Zhao Q, Liang T, Wang M, Sun P, et al.
The Chinese herbal medicine mixture, composed of Acorus gramineus, Phellodendron chinensis, and Cassia obtusifolia, demonstrated preventive and therapeutic effects on chickens infected with Aspergillus flavus and Aspergillus fumigatus, as evidenced by reduced granulomatous lesions in the liver, lower levels of Glutamic oxaloacetic transaminase (GOT) and Glutamate pyruvic transaminase (GPT), and decreased neutrophil count in blood smears.
Experimental Study Antifungal
Antifungal Mechanisms of a Chinese Herbal Medicine, Cao Huang Gui Xiang, Against Candida Species
2022 Mar 09 Frontiers in Pharmacology Yue H, Xu X, He S, Cui X, Guo Y, Zhao J, et al.
The CHGX formula demonstrated potent antifungal activities against Candida species both in vitro and in vivo, with efficacy in treating C. albicans infection in mice without causing noticeable toxicity. The formula inhibited biofilm formation, filament development, and disrupted cell membrane integrity in C. albicans, leading to the accumulation of reactive oxygen species (ROS) and depletion of adenosine triphosphate (ATP), ultimately resulting in fungal cell death. The study highlights the potential of CHGX as a therapeutic option for Candida infections and elucidates its antifungal mechanisms involving multiple pathways, including the Ras1-cAMP pathway and mitochondrial protein Mcu1.
Experimental StudyResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Bee pollen showcases a range of biological activities, such as anti-inflammatory, antimicrobial, and potential antiviral properties, which could contribute to the creation of innovative therapies.
2023 Molecules Chemical Properties and Biological Activity of Bee Pollen Rodríguez-Pólit C, Gonzalez-Pastor R, Heredia-Moya J, Carrera-Pacheco SE, Castillo-Solis F, Vallejo-Imbaquingo R, et al.
Review Article
The methodology used in the study involved analysing a diverse array of pollen types, in combination with their various chemical compositions. The primary aim of this was to updatedly assess the bioactive constituents present in bee pollen and consider the therapeutic possibilities they present. A focus of the study was on beehive pollen since it is a rich natural source of proteins and nutrients and exhibits immense chemical and therapeutic potential.
Discussion of results emphasized that the range of biological activities associated with bee pollen is truly remarkable. This activity ranges from anti-inflammatory and antimicrobial properties to potential antiviral and anticancer applications. Despite the challenge presented in fully understanding the vast array of biological properties across various pollen sources, this study has succeeded in emphasizing the potential extent of the therapeutic effectiveness of bee pollen. Its potential contribution on the path to discovering innovative therapies cannot be underestimated.
Curcumin, derived from turmeric, exhibits an extensive range of biological and medicinal properties, including anti-inflammatory, antioxidant, and antifungal qualities.
2021 Journal of the Science of Food and Agriculture Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability Abd El‐Hack ME, El‐Saadony MT, Swelum AA, Arif M, Abo Ghanima MM, Shukry M, et al.
Review Article Health Benefits
The research examines turmeric extracts, specifically focusing on curcumin, a yellow biocomponent. An array of its medicinal and biological properties is explored, particularly anti-inflammatory, antioxidant, and antifungal attributes. Traditionally used in various cultures for a range of health issues like inflammation, cough, wounds, liver disorders, and cancers, curcumin's extensive application in treating a variety of diseases potentially positions it as a significant component in modern medicine. The study also notes the successful tolerance of curcumin at high doses with no adverse effects.
The analysis extends to the preferred methods for the encapsulation of curcumin, detailing techniques such as nanocomplexing, gelation, complex coacervation, electrospraying, and solvent-free pH-driven encapsulation. These methods have demonstrated effectiveness in encapsulating curcuminoids. Moreover, the chemical traits of curcumin are also highlighted, providing a basis for further potential applications in the development of health-promoting functional products.
Star anise is the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu®), an antiviral medication for influenza A and influenza B.
2020 Phytotherapy Research Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance Jayanta Kumar Patra, Gitishree Das, Sankhadip Bose, Sabyasachi Banerjee, Chethala N. Vishnuprasad, Maria del Pilar Rodriguez-Torres, et al.
Review Article
Besides, several other molecules with numerous biological benefits including the antiviral effects have been reported from the same plant. Except the antiviral potential, star anise possesses a number of other potentials such as antioxidant, antimicrobial, antifungal, anthelmintic, insecticidal, secretolytic, antinociceptive, anti-inflammatory, gastroprotective, sedative properties, expectorant and spasmolytic, and estrogenic effects.
Honey, a natural food supplement, emerges as a potent therapeutic antioxidant with diverse medicinal effects, including wound healing, antibacterial, anti-inflammatory, antifungal, antiviral, and antidiabetic properties, suggesting its potential as a novel antioxidant in managing oxidative stress-related diseases.
2018 Oxidative Medicine and Cellular Longevity Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action Ahmed S, Sulaiman SA, Baig AA, Ibrahim M, Liaqat S, Fatima S, et al.
Review Article Antibacterial Honey Type 2 Diabetes
The research extensively reviews honey's medicinal effects, emphasizing its role as a therapeutic antioxidant. The study explores various mechanisms, including the modulation of multiple signaling pathways and molecular targets.
The evidence-based research underscores honey's role in alleviating diseases linked to oxidative stress. The reviewed pathways include caspase induction, cytokine stimulation, cell cycle regulation, and modulation of inflammatory markers. The comprehensive exploration of honey's therapeutic potential indicates its promise as a standalone or adjuvant antioxidant, necessitating further experimental and clinical investigation.
Fennel exhibits antifungal, antibacterial, antioxidant, antithrombotic and hepatoprotective activities.
2016 Arabian Journal of Chemistry Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety Manzoor A.Rather, Bilal A.Dar, Shahnawaz N.Sofia, Bilal A.Bhat, Mushtaq A.Qurishi
Review Article Antioxidant Fennel Seed
Fennel is a medicinal and aromatic plant with a diverse pharmacological spectrum and having considerable importance in particular to food industry. Its aroma active compounds such as anethole (and its polymers like dianethole and photoanethole) estragole, (+)-Fenchone and P-anisaldehyde have been recognised as the biologically active molecules possessing oestrogenic, acaricidal and antithrombotic activities. The phenolic molecules present in fennel have been shown to possess potent antioxidant activity in a number of experiments. These bioactive molecules in fennel can be developed as novel pharmacological lead molecules provided their bioavailability, pharmacokinetics, physiological pathways, and importance to human health are known with sufficient detail.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Chemical Properties and Biological Activity of Bee Pollen
2023 Nov 25 Molecules Rodríguez-Pólit C, Gonzalez-Pastor R, Heredia-Moya J, Carrera-Pacheco SE, Castillo-Solis F, Vallejo-Imbaquingo R, et al.
Review ArticleBee pollen showcases a range of biological activities, such as anti-inflammatory, antimicrobial, and potential antiviral properties, which could contribute to the creation of innovative therapies.
Antioxidant Properties and Structure-Antioxidant Activity Relationship of Allium Species Leaves
2021 Nov 26 Molecules Kurnia D, Ajiati D, Heliawati L, Sumiarsa D
Allium species such as A. cepa, A. sativum, A. fistulosum, A. schoenoprasum, A. ursinum, A. flavum, A. scorodoprasum, A. vineale and A. atroviolaceum have a great role in the health field. Those contain secondary metabolites that have several bioactivities such as antioxidant, antimicrobial, antibacterial, antifungal, anti-inflammatory and others. Their bioactivities are influenced by certain structure and functional groups.
Systematic Review Meta-Analysis AntioxidantCurcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability
2021 Jul 14 Journal of the Science of Food and Agriculture Abd El‐Hack ME, El‐Saadony MT, Swelum AA, Arif M, Abo Ghanima MM, Shukry M, et al.
Review Article Health BenefitsCurcumin, derived from turmeric, exhibits an extensive range of biological and medicinal properties, including anti-inflammatory, antioxidant, and antifungal qualities.
Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance
2020 Jan 29 Phytotherapy Research Jayanta Kumar Patra, Gitishree Das, Sankhadip Bose, Sabyasachi Banerjee, Chethala N. Vishnuprasad, Maria del Pilar Rodriguez-Torres, et al.
Review ArticleStar anise is the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu®), an antiviral medication for influenza A and influenza B.
NATURAL COMPOUNDS: A SUSTAINABLE ALTERNATIVE TO THE PHYTOPATHOGENS CONTROL
2019 Jun Journal of the Chilean Chemical Society Jiménez-Reyes MF, Carrasco H, Olea AF, Silva-Moreno E
In this review, we observe that natural compounds derived from plants are worthwhile to treat fungal infections; phytopathogens, which nowadays remain as one of the most common plant diseases, and also represent one of the most significant issues for agricultural companies. We could also observe that extracts, essential oils, and active compounds from plants have efficient antifungal agents, which are potent and less toxic against phytopathogenic fungus, rather than synthetic fungicides. Likewise, they could partially or entirely replace the use of chemical antifungals, which increase resistance in fungi and pollute the environment, generating an eco-friendly control mechanism as well as lowering costs for agricultural companies.
Review ArticlePresentation Slides
Bee pollen showcases a range of biological activities, such as anti-inflammatory, antimicrobial, and potential antiviral properties, which could contribute to the creation of innovative therapies.
Curcumin, derived from turmeric, exhibits an extensive range of biological and medicinal properties, including anti-inflammatory, antioxidant, and antifungal qualities.
Star anise is the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu®), an antiviral medication for influenza A and influenza B.
Honey, a natural food supplement, emerges as a potent therapeutic antioxidant with diverse medicinal effects, including wound healing, antibacterial, anti-inflammatory, antifungal, antiviral, and antidiabetic properties, suggesting its potential as a novel antioxidant in managing oxidative stress-related diseases.
Fennel exhibits antifungal, antibacterial, antioxidant, antithrombotic and hepatoprotective activities.
The bioactive compounds in Chrysanthemums can be used to develop next generation, multi-functional drugs for various diseases including diabetes and prostate cancer.
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Need full article — 21 Sep 2021