Blood Lipid

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Chinese Medicine Research Hub

Animal Study

Certain natural mineral waters, when combined with a low-calorie diet, effectively reduce cholesterol and glucose levels in mice with metabolic syndrome.

2022 Frontiers in Nutrition Natural Mineral Waters and Metabolic Syndrome: Insights From Obese Male and Female C57BL/6 Mice on Caloric Restriction
Narciso L, Martinelli A, Torriani F, Frassanito P, Bernardini R, Chiarotti F, Marianelli C

Chinese Medicine Research Hub

Meta-Analysis

Oat supplementation interventions can improve cardiovascular health markers among adults, regardless of their diet or metabolic conditions.

2022 European Journal of Nutrition Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials
Llanaj E, Dejanovic GM, Valido E, Bano A, Gamba M, Kastrati L, Minder B, Stojic S, Voortman T, Marques-Vidal P, Stoyanov J, Metzger B, Glisic M, Kern H, Muka T

Chinese Medicine Research Hub

Experimental Study

Consuming oats significantly lessens total and LDL cholesterol levels and mediates a prebiotic effect on the gut microbiome, contributing to its cholesterol-lowering ability.

2021 Frontiers in Immunology The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial
Xu D, Feng M, Chu YF, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y

Chinese Medicine Research Hub

Systematic Review

Fenugreek supplementation improved lipid parameters in adults.

2021 Journal of Ethnopharmacology Effect of fenugreek supplementation on blood lipids and body weight: A systematic review and meta-analysis of randomized controlled trials
Askarpour M, Alami F, Campbell MS, Venkatakrishnan K, Hadi A, Ghaedi E.

Chinese Medicine Research Hub

Systematic Review

The consumption of green tea significantly lowers low-density lipoprotein cholesterol and total cholesterol, but it does not affect high-density lipoprotein cholesterol or triglycerides.

2020 Nutrition Journal Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials
Xu R, Yang K, Li S, Dai M, Chen G

Chinese Medicine Research Hub

Systematic Review

Incorporating walnuts into the diet improved blood lipid profile without adversely affecting body weight or blood pressure.

2018 The American Journal of Clinical Nutrition Effects of walnut consumption on blood lipids and other cardiovascular risk factors: an updated meta-analysis and systematic review of controlled trials
Marta Guasch-Ferré, Jun Li, Frank B Hu, Jordi Salas-Salvadó, Deirdre K Tobias

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation significantly reduces blood triglycerides and total cholesterol levels without affecting low-density and high-density lipoprotein cholesterol.

2017 Journal of Clinical Lipidology The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis
Maierean SM, Serban MC, Sahebkar A, Ursoniu S, Serban A, Penson P, Banach M

Chinese Medicine Research Hub

Randomised Controlled Trial

Pomegranate juice consumption over a short period promotes red blood cell production without significantly changing metabolic health and inflammation markers in healthy individuals.

2017 Experimental and Therapeutic Medicine Effect of pomegranate juice consumption on biochemical parameters and complete blood count
Manthou E, Georgakouli K, Deli CK, Sotiropoulos A, Fatouros IG, Kouretas D, Haroutounian S, Matthaiou C, Koutedakis Y, Jamurtas AZ

Chinese Medicine Research Hub

Systematic Review

Almond consumption effectively reduces blood lipid levels, thus reducing risk of heart disease.

2016 Journal of Nutritional Science The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials
Musa-Veloso K, Paulionis L, Poon T, Lee HY

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Blood Lipid" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Blood Lipid" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Blood Lipid" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Animal Study published in 2022 in the journal Frontiers in Nutrition found that Certain natural mineral waters, when combined with a low-calorie diet, effectively reduce cholesterol and glucose levels in mice with metabolic syndrome. The study involved 125 male and female C57BL/6 mice. Ten mice were kept as a healthy control group, fed a standard diet with tap water. The remaining 115 mice were fed a high-calorie diet (60% fat, 10% fructose in water) for four months to induce metabolic syndrome, followed by a two-month treatment phase with a low-calorie diet and various types of natural mineral water (NMW). The mice were divided into six treatment groups, each receiving a different NMW, and a control group receiving tap water. The study monitored body weight and blood biochemistry over six months. After four months on a high-calorie diet, both male and female mice developed obesity, high cholesterol, and high blood sugar, with males showing greater increases. During the treatment phase, NMWs rich in sulphate, magnesium, bicarbonate, and minimally mineralized water, along with a low-calorie diet, significantly lowered total cholesterol, HDL cholesterol, and glucose levels. Sex differences were observed during both the induction and treatment phases. These findings indicate that specific NMWs, in conjunction with a low-calorie diet, may help manage blood lipid and glucose levels in metabolic syndrome, although further research is needed to confirm these results in humans.

A Meta-Analysis published in 2022 in the journal European Journal of Nutrition found that Oat supplementation interventions can improve cardiovascular health markers among adults, regardless of their diet or metabolic conditions. The methodology involved analyzing various randomized clinical trials that tested how oats, or extracts rich in oat beta-glucan and avenanthramides affected markers of cardiovascular disease risk. The sample population was predominantly subjects with high cholesterol, obesity, and mild metabolic disturbances. Interventions were compared to control arms without oats. In the discussion on results, it was found that subjects receiving the oat supplementation had improved health metrics such as total cholesterol, LDL cholesterol, glucose levels, body mass index, weight, and waist circumference. However, when the oat supplementation was compared to heterogeneous interventions, like wheat, eggs, rice, etc., reductions in the levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol, and apolipoprotein B were also seen. Despite these promising results, there were some concerns around the bias risk associated with the majority of included randomized clinical trials.

A Experimental Study published in 2021 in the journal Frontiers in Immunology found that Consuming oats significantly lessens total and LDL cholesterol levels and mediates a prebiotic effect on the gut microbiome, contributing to its cholesterol-lowering ability. In a randomized controlled study, 210 mildly hypercholesterolemic subjects from three various study centers across China were assigned to consume either 80 g of oats or rice daily for 45 days. To ascertain the effects of these diets, measurements were taken of the participants' plasma lipid profiles, short chain fatty acids (SCFAs), and fecal microbiota. Following 30 and 45 days of adherence to these diets, there was a pronounced reduction in total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C) in both the oat-consuming and rice-consuming participants. This decrease was more articulated amongst the oat consumers by the 45th day. The consumption of oats led to a significant increase in the abundance of certain beneficial gut microbiota and a corresponding decrease in unclassified harmful types. These microbiota demonstrated associations with changes in plasma lipid levels and SCFAs. The comprehensive findings strongly suggest that the cholesterol-reducing effect of oats may be largely down to its prebiotic activity, which modulates the gut microbiome.

A Systematic Review published in 2021 in the journal Journal of Ethnopharmacology found that Fenugreek supplementation improved lipid parameters in adults. A meta-analysis of 12 RCTs (14 arms) with 560 participants suggested a significant decrease in plasma concentrations of total cholesterol, triglycerides, and low density lipoprotein cholesterol, as well as an increase in plasma high density lipoprotein cholesterol, while body weight and body mass index were not altered.

A Systematic Review published in 2020 in the journal Nutrition Journal found that The consumption of green tea significantly lowers low-density lipoprotein cholesterol and total cholesterol, but it does not affect high-density lipoprotein cholesterol or triglycerides. To gather data for this study, a comprehensive literature review and meta-analysis were conducted using PubMed, Embase, and the Cochrane Library. The databases were searched from their inception to September 2019 for all studies related to the effect of green tea on blood lipids. Information from these studies, which included randomized and controlled trials, was used to estimate blood lipid changes resulting from green tea supplementation. The collected information underwent rigorous assessment for any potential bias. The analysis of data derived from 31 different trials involving a total of 3321 subjects showed that green tea intake has a significant effect in lowering low-density lipoprotein cholesterol and total cholesterol levels. However, consumption of green tea did not yield significant changes in the levels of high-density lipoprotein cholesterol or triglycerides. The results remained consistent across both normal-weight and overweight-obese subjects. No significant publication bias was detected from the collected studies, fortifying the reliability of the results.

A Systematic Review published in 2018 in the journal The American Journal of Clinical Nutrition found that Incorporating walnuts into the diet improved blood lipid profile without adversely affecting body weight or blood pressure. The present meta-analysis of controlled trials provides robust evidence for the benefits of walnut consumption on blood lipids without adversely affecting body weight or blood pressure and supports the results of epidemiologic studies showing inverse associations between walnut consumption and CVD risk. Despite walnuts being energy-dense, the consumption of walnuts does not promote weight gain and thus they can be incorporated into an overall healthy dietary pattern to enhance health benefits.

A Systematic Review published in 2017 in the journal Journal of Clinical Lipidology found that Cinnamon supplementation significantly reduces blood triglycerides and total cholesterol levels without affecting low-density and high-density lipoprotein cholesterol. The study's methodology included the systematic review and evaluation of 13 randomized controlled trials involving 750 participants. These trials examined the impact of cinnamon supplementation on blood lipid concentrations. The researchers performed a meta-analysis employing random effect models and calculated weighted mean differences for endpoints using a random effects model too. The results of the study indicated no substantial effect of cinnamon on low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations. However, a significant decrease in blood triglycerides and total cholesterol concentrations was observed. Furthermore, in a meta-regression analysis, no notable association was found between changes in lipid parameters and the dosage of cinnamon. However, changes in total cholesterol, LDL-C, and triglycerides were positively linked with the duration of supplementation.

A Randomised Controlled Trial published in 2017 in the journal Experimental and Therapeutic Medicine found that Pomegranate juice consumption over a short period promotes red blood cell production without significantly changing metabolic health and inflammation markers in healthy individuals. In the methodology of this study, ten healthy subjects (five males and five females averaging 31.8 years of age and weighing an average of 66.2 kg) were split into two groups. One group drank 500 ml of pomegranate juice every day for 14 days, while the other did not. Blood samples were taken from the subjects before and after the experimental period to measure various health markers. In the discussion of results, it was observed that pomegranate juice intake led to a substantial rise in red blood cell count, hemoglobin levels, and hematocrit levels. However, other complete blood count parameters, and levels of glucose, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and C-reactive protein remained largely unaffected after the juice consumption. This suggests that pomegranate juice only had a substantial effect on increasing erythropoiesis or decreasing degradation in healthy individuals.

A Systematic Review published in 2016 in the journal Journal of Nutritional Science found that Almond consumption effectively reduces blood lipid levels, thus reducing risk of heart disease. The researchers carried out a systematic review and meta-analysis drawing on data from controlled randomised trials. Their search of the scientific literature led them to a total of eighteen relevant publications and twenty-seven datasets, which offered a comparison between almond consumption and a control group. They then unified the studies by pooling the mean differences in the effects on each blood lipid parameter using a random-effects model. The analysis found that consuming almonds had a marked beneficial effect on levels of total cholesterol, LDL-cholesterol and TAG (triacylglycerol). However, it did not significantly affect HDL-cholesterol levels. This supports data from previous observational and large-scale interventional studies that showed nut consumption reduces the risk of heart disease. This goes to show that including nuts in a balanced diet is advisable for maintaining healthy blood lipid levels and preventing heart disease.

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