Chemotherapy-Induced Peripheral Neuropathy
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Also known as: CIPN
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
The Potential Role of Ziziphus Jujube in the Management of Chemotherapy-Induced Peripheral Neuropathy
2024 Jun 30 Journal of Tumor Science Research , Talabaki H, Salehifar E,
Chemotherapy-Induced Peripheral Neuropathy Chemotherapy JujubeThis article was submitted by Jinnan C. and is awaiting moderation..

Acupuncture improves chemotherapy-induced neuropathy explored by neurophysiological and clinical outcomes – The randomized, controlled, cross-over ACUCIN trial
2022 Sep Phytomedicine Friedemann T, Kark E, Cao N, Klaßen M, Meyer-Hamme G, Greten JH, et al.
Randomised Controlled Trial Chemotherapy Acupuncture Neuropathy Chemotherapy-Induced Peripheral NeuropathyThis article was submitted by Jinnan C. and is awaiting moderation..
Acupuncture has shown potential in enhancing structural nerve regeneration in Chemotherapy-induced peripheral neuropathy, leading to subjective improvements and positive neurological findings.

Clinical Efficacy and Potential Mechanisms of Acupoint Stimulation Combined With Chemotherapy in Combating Cancer: A Review and Prospects
2022 Apr 25 Frontiers in Oncology Li S, Zhao S, Guo Y, Yang Y, Huang J, Wang J, et al.
In conclusion, the evidence suggests that acupoint stimulation can alleviate the side effects of chemotherapy and can also assist chemotherapeutic agents in inhibiting tumor growth, which expands the clinical application of acupoint stimulation in cancer treatment.
Review Article
External Treatment With Chinese Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis
2022 Feb 18 Frontiers in Pharmacology Li Q, Cai F, Lu Y, Liu H, Wang X, Li F, et al.
Chinese herbal medicine (CHM) external treatment was found to be an effective method for treating chemotherapy-induced peripheral neuropathy (CIPN) as it significantly improved clinical symptoms and quality of life in patients with CIPN.
Systematic Review Meta-Analysis Chemotherapy-induced peripheral neuropathy (CIPN) Chinese Herbal Medicine Chemotherapy-Induced Peripheral Neuropathy
A systematic review and meta-analysis of the efficacy of acupuncture and electroacupuncture against chemotherapy-induced peripheral neuropathy
2020 Apr 24 Medicine Hwang MS, Lee HY, Choi TY, et al.
Systematic Review Meta-Analysis Chemotherapy-Induced Peripheral NeuropathyAcupuncture has been shown to be more effective than vitamin B treatment in terms of clinical efficacy rate for chemotherapy induced peripheral neuropathy.
Research insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.

2022 Phytomedicine
Acupuncture has shown potential in enhancing structural nerve regeneration in Chemotherapy-induced peripheral neuropathy, leading to subjective improvements and positive neurological findings.
Randomised Controlled Trial Acupuncture Chemotherapy Neuropathy
Acupuncture improves chemotherapy-induced neuropathy explored by neurophysiological and clinical outcomes – The randomized, controlled, cross-over ACUCIN trial
Friedemann T, Kark E, Cao N, Klaßen M, Meyer-Hamme G, Greten JH, et al.

2020 Medicine
Acupuncture has been shown to be more effective than vitamin B treatment in terms of clinical efficacy rate for chemotherapy induced peripheral neuropathy.
Systematic Review
A systematic review and meta-analysis of the efficacy of acupuncture and electroacupuncture against chemotherapy-induced peripheral neuropathy
Hwang MS, Lee HY, Choi TY, et al.

2020 JAMA Oncology
Compared with usual care, acupuncture resulted in significant improvement in chemotherapy-induced peripheral neuropathy symptoms.
Randomised Controlled Trial Chemotherapy
Effect of Acupuncture vs Sham Procedure on Chemotherapy-Induced Peripheral Neuropathy Symptoms A Randomized Clinical Trial
Bao T, Patil S, Chen C, et al.

2019 The Oncologist
Acupuncture treatment significantly improves neuropathic symptoms in women suffering from chemotherapy-induced peripheral neuropathy after breast cancer therapy.
Randomised Controlled Trial Cancer Treatment Support Chemotherapy
Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial
Lu W, Giobbie-Hurder A, Freedman RA, Shin IH, Lin NU, Partridge AH, et al.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.

Clinical Efficacy and Potential Mechanisms of Acupoint Stimulation Combined With Chemotherapy in Combating Cancer: A Review and Prospects
2022 Apr 25 Frontiers in Oncology Li S, Zhao S, Guo Y, Yang Y, Huang J, Wang J, et al.
In conclusion, the evidence suggests that acupoint stimulation can alleviate the side effects of chemotherapy and can also assist chemotherapeutic agents in inhibiting tumor growth, which expands the clinical application of acupoint stimulation in cancer treatment.
Review Article
External Treatment With Chinese Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis
2022 Feb 18 Frontiers in Pharmacology Li Q, Cai F, Lu Y, Liu H, Wang X, Li F, et al.
Chinese herbal medicine (CHM) external treatment was found to be an effective method for treating chemotherapy-induced peripheral neuropathy (CIPN) as it significantly improved clinical symptoms and quality of life in patients with CIPN.
Systematic Review Meta-Analysis Chemotherapy-induced peripheral neuropathy (CIPN) Chinese Herbal Medicine Chemotherapy-Induced Peripheral Neuropathy
A systematic review and meta-analysis of the efficacy of acupuncture and electroacupuncture against chemotherapy-induced peripheral neuropathy
2020 Apr 24 Medicine Hwang MS, Lee HY, Choi TY, et al.
Systematic Review Meta-Analysis Chemotherapy-Induced Peripheral NeuropathyAcupuncture has been shown to be more effective than vitamin B treatment in terms of clinical efficacy rate for chemotherapy induced peripheral neuropathy.

Acupuncture in adults with Chemotherapy-Induced Peripheral Neuropathy: a systematic review
2019 Jan Revista Latino-Americana de Enfermagem Baviera AF, Olson K, Paula JM, Toneti BF, Sawada NO
Acupuncture was associated with an improvement in peripheral neuropathy symptoms in all five included studies; however, variations in treatment protocols, medication use, timing, and outcome measures posed challenges in direct comparisons. The use of acupuncture appeared beneficial and without side effects, but more experimental studies with comprehensive measures are needed to enhance the evidence.
Cohort Study Systematic Review Acupuncture
The Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Meta-Analysis
2019 Jan Integrative Cancer Therapies Chien TJ, Liu CY, Fang CJ, Kuo CY
Acupuncture demonstrated significant improvements in pain scores and nervous system symptoms based on Functional Assessment of Cancer Therapy/Neurotoxicity questionnaire scores; however, no significant change was noted in nerve conduction velocity. The study suggests that acupuncture can effectively relieve CIPN pain and functional limitations, but larger-scale studies are needed due to the limited number of subjects.
Meta-Analysis Systematic Review Acupuncture Chemotherapy-Induced Peripheral NeuropathyClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.

Acupuncture improves chemotherapy-induced neuropathy explored by neurophysiological and clinical outcomes – The randomized, controlled, cross-over ACUCIN trial
2022 Sep Phytomedicine Friedemann T, Kark E, Cao N, Klaßen M, Meyer-Hamme G, Greten JH, et al.
Randomised Controlled Trial Chemotherapy Acupuncture Neuropathy Chemotherapy-Induced Peripheral NeuropathyThis article was submitted by Jinnan C. and is awaiting moderation..
Acupuncture has shown potential in enhancing structural nerve regeneration in Chemotherapy-induced peripheral neuropathy, leading to subjective improvements and positive neurological findings.

Effect of Acupuncture vs Sham Procedure on Chemotherapy-Induced Peripheral Neuropathy Symptoms A Randomized Clinical Trial
2020 Mar 11 JAMA Oncology Bao T, Patil S, Chen C, et al.
Randomised Controlled Trial Chemotherapy-Induced Peripheral Neuropathy ChemotherapyCompared with usual care, acupuncture resulted in significant improvement in chemotherapy-induced peripheral neuropathy symptoms.

Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial
2019 Oct 14 The Oncologist Lu W, Giobbie-Hurder A, Freedman RA, Shin IH, Lin NU, Partridge AH, et al.
Randomised Controlled Trial Cancer Treatment Support ChemotherapyAcupuncture treatment significantly improves neuropathic symptoms in women suffering from chemotherapy-induced peripheral neuropathy after breast cancer therapy.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides

Randomised Controlled Trial
Acupuncture has shown potential in enhancing structural nerve regeneration in Chemotherapy-induced peripheral neuropathy, leading to subjective improvements and positive neurological findings.
Friedemann T, Kark E, Cao N, Klaßen M, Meyer-Hamme G, Greten JH, Rostock M, Buhlmann E, Zhao A, Schröder S

Systematic Review
Acupuncture has been shown to be more effective than vitamin B treatment in terms of clinical efficacy rate for chemotherapy induced peripheral neuropathy.
Hwang MS, Lee HY, Choi TY, et al.

Randomised Controlled Trial
Compared with usual care, acupuncture resulted in significant improvement in chemotherapy-induced peripheral neuropathy symptoms.
Bao T, Patil S, Chen C, et al.

Randomised Controlled Trial
Acupuncture treatment significantly improves neuropathic symptoms in women suffering from chemotherapy-induced peripheral neuropathy after breast cancer therapy.
Lu W, Giobbie-Hurder A, Freedman RA, Shin IH, Lin NU, Partridge AH, Rosenthal DS, Ligibel JA
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Chemotherapy-Induced Peripheral Neuropathy" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Chemotherapy-Induced Peripheral Neuropathy" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Chemotherapy-Induced Peripheral Neuropathy" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Randomised Controlled Trial published in 2022 in the journal Phytomedicine found that Acupuncture has shown potential in enhancing structural nerve regeneration in Chemotherapy-induced peripheral neuropathy, leading to subjective improvements and positive neurological findings. This research was conducted at the HanseMerkur Center for TCM at the University Medical Center, Hamburg-Eppendorf. Sixty patients who had been diagnosed with Chemotherapy-induced peripheral neuropathy underwent acupuncture treatment. Patients were selected based on physical examinations, subjective and quantitative evaluations conducted using nerve conduction studies. They were then randomly divided into two groups. The first group received a ten-week acupuncture treatment while the latter was put on a waiting list. After fourteen weeks, evaluations were carried out on both groups. The second group then received the acupuncture treatment while group one was put on the waiting list. Both groups were subjected to another evaluation after 28 weeks. The results showed noticeable improvements in sural sensory nerve amplitude and sural nerve conduction velocity among patients who received acupuncture treatment. This can be seen in the subjective improvements reported by the patients in the form of reduced burning pain, cramps, numbness, frequency of symptoms and improved gait. Significantly positive findings from the physical examination, including blind walking, heel-to-toe walking, and distal pallhypesthesia further bolster the potential benefits of acupuncture treatment in managing Chemotherapy-induced peripheral neuropathy.
A Systematic Review published in 2020 in the journal Medicine found that Acupuncture has been shown to be more effective than vitamin B treatment in terms of clinical efficacy rate for chemotherapy induced peripheral neuropathy. Aside from 1 study using sham-EA as a control group, all 12 studies included acupuncture versus pharmacological treatments. The results showed that acupuncture could show a superior clinical efficacy than vitamin B therapy. However, the methodological quality of the involved studies was generally low.
A Randomised Controlled Trial published in 2020 in the journal JAMA Oncology found that Compared with usual care, acupuncture resulted in significant improvement in chemotherapy-induced peripheral neuropathy symptoms. We found therapeutic benefit of real acupuncture for neuropathic pain that is consistent with previous pilot acupuncture CIPN trials. Distinctively, our study is the first, to our knowledge, to incorporate a sham treatment and a nontreatment control to evaluate the efficacy of acupuncture for CIPN. The addition of a sham acupuncture control in an acupuncture clinical trial is difficult owing to the challenge of incorporating a truly inert placebo. In addition, a sham control limits the ability of a small effect size to elucidate a true difference between real and sham acupuncture. Not only did our study demonstrate the feasibility of conducting a sham-controlled acupuncture trial, it generated sufficient pilot data to inform a definitive sham-controlled efficacy trial. Our trial is limited by its small sample size, single center, and short-term follow-up.
A Randomised Controlled Trial published in 2019 in the journal The Oncologist found that Acupuncture treatment significantly improves neuropathic symptoms in women suffering from chemotherapy-induced peripheral neuropathy after breast cancer therapy. In this randomized pilot trial, women with stage I-III breast cancer with grade 1 or higher chemotherapy-induced peripheral neuropathy post adjuvant chemotherapy were tested. Patients were split evenly into two groups: an immediate acupuncture group and a control group. Those in the immediate acupuncture arm underwent 18 acupuncture sessions over 8 weeks before the treatment was halted. Conversely, the control group received the usual care over eight weeks before beginning nine acupuncture sessions across the same time span. Different parameters such as sensory scores, neurotoxicity, and pain severity were evaluated at the start, then at 4, 8, and 16 weeks post enrollment. The results, which excluded any statistical references, showed a notable improvement in the immediate acupuncture group in terms of neuropathic symptoms, including sensory scores, neurotoxicity summary score, and pain severity score when observed at the end of eight weeks. No negative side effects were observed during the entire period. This indicates acupuncture as a potential therapeutic option for breast cancer patients suffering from chemotherapy-induced peripheral neuropathy.
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