Clomiphene Citrate

Presentation Slides

Chinese Medicine Research Hub

Cohort Study

Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency.

2023 Nutrients Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor HS, Singh B, Flaminia A, Flores VA, Christman GM, Huang H, Johnson JJ, Zhang H

Chinese Medicine Research Hub

Systematic Review

Black cohosh indicated potential benefits in hormone regulation and endometrial thickness, alongside safety in short-term use.

2021 Journal of Pharmacy Practice Systematic Review of Black Cohosh (Cimicifuga racemosa) for Management of Polycystic Ovary Syndrome-Related Infertility
Fan CW, Cieri-Hutcherson NE, Hutcherson TC

Chinese Medicine Research Hub

Systematic Review

The use of acupuncture as a monotherapy significantly improved the rate of pregnancy among the study participants compared with the use of clomiphene citrate alone.

2019 Acupuncture in Medicine Acupuncture and clomiphene citrate for anovulatory infertility: a systematic review and meta-analysis
Gao R, Guo B, Bai J, Wu Y, Wu K

Chinese Medicine Research Hub

Systematic Review

Acupuncture and its combined therapy may be effective for treating female infertility, however, the included studies are not robust enough to draw a firm conclusion.

2019 Medicine Acupuncture for infertile women without undergoing assisted reproductive techniques (ART)
Yun L, Liqun W, Shuqi Y, Chunxiao W, Liming L, Wei Y

Chinese Medicine Research Hub

Systematic Review

Chinese herbal medicine combined with moxibustion might be beneficial for treating PCOS, and the treatment might improve the therapeutic effects of conventional western medications including clomiphene citrate, oral contraceptives, and/or metformin.

2018 Medicine Oriental herbal medicine and moxibustion for polycystic ovary syndrome
Kwon, Chan-Young, Lee, Boram, Park, Kyoung Sun

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Clomiphene Citrate" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Clomiphene Citrate" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Clomiphene Citrate" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Cohort Study published in 2023 in the journal Nutrients found that Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency. The study involved the pre-testing of a green tea substance known as Epigallocatechin gallate (EGCG) on a cohort of premenopausal women, aged 18 to 40, with and without uterine fibroids, in order to evaluate its safety. The subjects were randomized into three groups, each receiving different treatments. One group took just a daily dose of 800 mg of EGCG, one group combined this EGCG dose with 100 mg of Clomiphene citrate for five days, and the third group combined it with 5 mg of Letrozole for the same period. The results showed that none of the subjects displayed signs of drug-induced liver injury, and all had normal serum folate levels. Hence, the findings suggest that the daily intake of 800mg of EGCG, whether consumed alone or in combination with Clomiphene citrate or Letrozole for five days, is well-tolerated and not related to any liver toxicity or folate deficiency in women of reproductive age.

A Systematic Review published in 2021 in the journal Journal of Pharmacy Practice found that Black cohosh indicated potential benefits in hormone regulation and endometrial thickness, alongside safety in short-term use. This passage discusses a systematic review that aimed to evaluate the effectiveness and safety of black cohosh for inducing ovulation, regulating hormones, and improving pregnancy rates in women with polycystic ovary syndrome (PCOS)-related infertility. The review involved searching various databases for relevant studies and assessing their quality. Two randomized controlled trials (RCTs) met the inclusion criteria, and additional records were identified from clinical trial registries. The findings suggest that black cohosh may improve hormone regulation and endometrial thickness compared to clomiphene citrate (CC). Three RCTs reported improved pregnancy rates with black cohosh combined with CC. Adverse events were similar between groups. However, the studies had certain risk-of-bias concerns, and overall, there is insufficient high-quality evidence to firmly support the effectiveness of black cohosh in improving pregnancy rates in PCOS-related infertility. The short-term use of black cohosh appears to be safe.

A Systematic Review published in 2019 in the journal Acupuncture in Medicine found that The use of acupuncture as a monotherapy significantly improved the rate of pregnancy among the study participants compared with the use of clomiphene citrate alone. The use of acupuncture in the treatment of infertility may be an appropriate alternative for some patients. To our knowledge, this is the first meta-analysis available to date that compares the use of acupuncture alone or together with clomiphene citrate versus clomiphene citrate alone in the treatment of anovulatory infertility. While some results were promising, their validity is limited by questionable methodological designs, lack of sufficient allocation concealment, inadequate sample sizes and limited long-term follow-up. As such, any results drawn from these studies should be interpreted with caution and applied with care to clinical practice.

A Systematic Review published in 2019 in the journal Medicine found that Acupuncture and its combined therapy may be effective for treating female infertility, however, the included studies are not robust enough to draw a firm conclusion. Current evidence identified from this review suggested that acupuncture may be effective in the treatment of female infertility. The conclusion of this present review is limited by the low quality of the included studies. Future multicenter RCTs with rigorous methodological quality are needed to clarify the role of acupuncture in female infertility.

A Systematic Review published in 2018 in the journal Medicine found that Chinese herbal medicine combined with moxibustion might be beneficial for treating PCOS, and the treatment might improve the therapeutic effects of conventional western medications including clomiphene citrate, oral contraceptives, and/or metformin. According to current evidence, oriental herbal medicine combined with moxibustion might be beneficial for treating PCOS. Moreover, the treatment might improve the therapeutic effects of conventional WMs including clomiphene citrate, OCPs, and/or metformin. However, the findings should be interpreted with great caution, owing to poor methodological quality of the included studies, especially the high risks of selection bias, performance bias, and detection bias. Further larger, high-quality, rigorous RCTs should be conducted in this regard.

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