Cold Sore
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A cold sore is a small, fluid-filled blister that typically appears on or around the lips and is caused by the herpes simplex virus.
Also known as: Herpes Simplex, HSV-1
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Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.

Case report: Tongdu Xingshen acupuncture for a patient with persistent vegetative state after herpes simplex virus encephalitis
2022 Oct 03 Frontiers in Neurology Jin B, Tang Y, Wu Y, Liu Z
We present the case of a 4-month-long PVS after herpes simplex virus encephalitis (HSVE) in a 3.5-year-old boy who underwent Tongdu Xingshen acupuncture integrated with Western medicine and rehabilitation. The patient regained consciousness post-treatment and regained intelligence and motor abilities after 7 sessions. Tongdu Xingshen acupuncture is a potential complementary therapy to optimize clinical outcomes in PVS.
Case Report Acupuncture Persistent Vegitative State Cold Sore
Efficacy and safety of oral Chinese herbal medicine combined with nucleoside antiviral drugs against recurrent genital herpes: a systematic review and meta-analysis
2022 Jan Traditional Medicine Research Liu TL, Liu T, Jin XM, Shao QQ, Wang WJ, Huang C, et al.
Chinese herbal medicine combined with nucleoside antiviral drugs can effectively reduce the recurrence rate of recurrent genital herpes, improve the patient’s quality of life and enhance the body’s immunity.
Systematic Review Meta-Analysis Cold Sore
Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores—A Clinical Study
2021 Dec 04 Pharmaceuticals Naik PP, Mossialos D, Wijk B, Novakova P, Wagener FADTG, Cremers NAJ
Randomised Controlled Trial Cold SoreMedical-grade honey outperforms conventional treatment in healing cold sores, reducing healing time and alleviating associated symptoms like pain and itching.

The Chinese herbal prescription JZ-1 induces autophagy to protect against herpes simplex Virus-2 in human vaginal epithelial cells by inhibiting the PI3K/Akt/mTOR pathway
2020 May Journal of Ethnopharmacology Shao Q, Liu T, Wang W, Duan Q, Liu T, Xu L, et al.
Our results showed that JZ-1 protects against HSV-2 infection, and this beneficial effect may be mediated by inducing autophagy via inhibition of the PI3K/Akt/mTOR signaling axis.
Cold Sore
Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
2018 Oct 20 International Journal of Molecular Sciences Li W, Wang XH, Luo Z, Liu LF, Yan C, Yan CY, et al.
TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described.
Review Article Cold SoreResearch insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.

2021 Pharmaceuticals
Medical-grade honey outperforms conventional treatment in healing cold sores, reducing healing time and alleviating associated symptoms like pain and itching.
Randomised Controlled Trial
Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores—A Clinical Study
Naik PP, Mossialos D, Wijk B, Novakova P, Wagener FADTG, Cremers NAJ
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.

Efficacy and safety of oral Chinese herbal medicine combined with nucleoside antiviral drugs against recurrent genital herpes: a systematic review and meta-analysis
2022 Jan Traditional Medicine Research Liu TL, Liu T, Jin XM, Shao QQ, Wang WJ, Huang C, et al.
Chinese herbal medicine combined with nucleoside antiviral drugs can effectively reduce the recurrence rate of recurrent genital herpes, improve the patient’s quality of life and enhance the body’s immunity.
Systematic Review Meta-Analysis Cold Sore
Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
2018 Oct 20 International Journal of Molecular Sciences Li W, Wang XH, Luo Z, Liu LF, Yan C, Yan CY, et al.
TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described.
Review Article Cold SoreClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides

Randomised Controlled Trial
Medical-grade honey outperforms conventional treatment in healing cold sores, reducing healing time and alleviating associated symptoms like pain and itching.
Naik PP, Mossialos D, Wijk B, Novakova P, Wagener FADTG, Cremers NAJ
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Cold Sore" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Cold Sore" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Cold Sore" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Randomised Controlled Trial published in 2021 in the journal Pharmaceuticals found that Medical-grade honey outperforms conventional treatment in healing cold sores, reducing healing time and alleviating associated symptoms like pain and itching. The methodology in this study involved a crossover trial with a group of 29 patients with recurrent cold sores. The majority of these patients experienced four or more episodes per year, so they served as their own control group. These patients applied a medical-grade honey product called L-Mesitran Soft to their cold sore either at the onset of symptoms or upon the appearance of the blister. After the healing process, they answered a questionnaire, assessing the effectiveness of the honey treatment based on healing time, pain, and itching level. Researchers found that the average healing time was significantly less with the honey treatment in comparison to conventionally used treatments. The honey treatment led to faster healing in 86.2% of all patients and increased subjective healing score in 79.3% of the patients. Moreover, patients experiencing pain and itching with cold sores reported a reduction in these symptoms when treated with medical-grade honey. Additionally, all the patients expressed a preference for the honey treatment over conventional ones for future cold sores. This suggests the potential of MGH as a superior alternative treatment for cold sores.
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