Ferroptosis
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Qi Shen Tang, a traditional Chinese medicine, was found to suppress retinal cell death in retinitis pigmentosa by inhibiting a process called ferroptosis.
Ferroptosis Qi Shen Tang Retinitis Pigmentosa
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway
2023 Nov Heliyon Xiong M, Ou C, Yu C, Qiu J, Lu J, Fu C, et al.
Experimental Study Ferroptosis Qi Shen Tang Retinitis PigmentosaQi Shen Tang, a traditional Chinese medicine, was found to suppress retinal cell death in retinitis pigmentosa by inhibiting a process called ferroptosis.
Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa
2023 Nov Biomedicine & Pharmacotherapy Yang Y, Wang Y, Deng Y, Lu J, Xiao L, Li J, et al.
Experimental Study Goji Berry Retinitis PigmentosaFructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) shows potential as a clinical treatment for retinitis pigmentosa by inhibiting photoreceptor cell death following oxidative stress.
Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression
2020 Jun Biomedicine & Pharmacotherapy Gao Z, Deng G, Li Y, Huang H, Sun X, Shi H, et al.
In conclusion, Actinidia chinensis Planch (ACP) was a promising antineoplastic agent for the treatment of gastric cancer by regulating apoptosis, ferroptosis and mesenchymal phenotype.
Network Pharmacology Stomach CancerResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Qi Shen Tang, a traditional Chinese medicine, was found to suppress retinal cell death in retinitis pigmentosa by inhibiting a process called ferroptosis.
2023 Heliyon Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway Xiong M, Ou C, Yu C, Qiu J, Lu J, Fu C, et al.
Experimental Study Qi Shen Tang Retinitis Pigmentosa
The researchers investigated the potential mechanism of Qi-Shen-Tang (QST), a combination of two traditional Chinese medicines, on retinitis pigmentosa, an eye disease. They induced a retinitis pigmentosa model in mice while subsequently treating them with QST. They then examined the impact of the medicine on the tissue morphology and function of the retina in these model mice, in addition to monitoring factors such as retinal blood flow and fundus structure.
The study found that the treatment with QST led to notable improvements in the retinal tissue morphology and function. In addition, they observed an increase in retinal blood flow and normalization of the fundus structure. Following the treatment, the amounts of iron and malondialdehyde in the retinal tissue were significantly reduced, while the levels of superoxide dismutase, glutathione, and the protein expressions of various enzymes significantly increased. Molecular docking results also revealed potential interactions between the components of QST and key proteins of a particular signaling pathway, namely the Nuclear factor erythroid 2-related factor 2/ Glutathione peroxidase 4 pathway. The results suggest that QST may inhibit ferroptosis by suppressing this signaling pathway, thereby mitigating retinitis pigmentosa-induced damage to the retinal tissue.
Fructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) shows potential as a clinical treatment for retinitis pigmentosa by inhibiting photoreceptor cell death following oxidative stress.
2023 Biomedicine & Pharmacotherapy Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa Yang Y, Wang Y, Deng Y, Lu J, Xiao L, Li J, et al.
Experimental Study Goji Berry Retinitis Pigmentosa
The study utilized hydrogen peroxide to induce oxidative stress in 661 W cells, which were examined with flow cytometry and an enzyme-linked immunosorbent assay. The impact of this oxidative stress on the cells’ mitochondria was observed using an electron microscope to understand the nature of cell death. The study also analyzed the compensatory effect of the Fructus Lycii and Salvia miltiorrhiza Bunge extract on the retinal structure and function of rd10 mice using histopathological examination, fundus photographs, and electroretinography. Protein levels were evaluated using Western blot assays, specifically targeting proteins including Tumor Protein p53, Solute Carrier Family 7 Member 11, Glutathione peroxidase 4, Arachidonate-12-Lipoxygenase, and Dipeptidyl peptidase 4.
The results showed that hydrogen peroxide-induced oxidative stress in 661 W cells increased oxidative stress products and certain protein expressions, while decreasing others. Notably, the activation of Glutathione peroxidase 4 did not lessen reactive oxygen species generation and had little impact on cell death. The research discovered that both Ferrostatin-1 and the extract could lessen reactive oxygen species generation and inhibit cell death of photoreceptors in retinitis pigmentosa, achieving this by inhibiting the expression of one protein and increasing the expression of two others.
Presentation Slides
Qi Shen Tang, a traditional Chinese medicine, was found to suppress retinal cell death in retinitis pigmentosa by inhibiting a process called ferroptosis.
Fructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) shows potential as a clinical treatment for retinitis pigmentosa by inhibiting photoreceptor cell death following oxidative stress.
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