GABA system
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Jujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
Anxiety GABA system Serotonin
Gan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
GABA GABA system Gan Mai Da Zao Tang
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Regulation of GABAA and 5-HT Receptors Involved in Anxiolytic Mechanisms of Jujube Seed: A System Biology Study Assisted by UPLC-Q-TOF/MS and RT-qPCR Method
2020 Oct 15 Frontiers in Pharmacology Chen L, Zhang X, Hu C, Zhang Y, Zhang L, Kan J, et al.
Experimental Study Anxiety GABA system Suan Zao Ren SerotoninJujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction
2019 Jan 22 Frontiers in Neuroscience Chen HS, Gu LJ, Yang YX, Guo JY
Animal Study GABA Serotonin Gan Mai Da Zao Tang GABA systemGan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
Acupuncture at HT7 suppresses morphine self-administration at high dose through GABA system
2014 Jul Neuroscience Letters Lee BH, Ku JY, Zhao RJ, Kim HY, Yang CH, Gwak YS, et al.
Acupuncture at HT7, but not at control acupoint, LI5, suppressed spontaneous morphine-taking behavior significantly. In addition, the effect of acupuncture was blocked by both GABA receptor antagonists. The results of this study suggest that acupuncture at HT7 suppresses morphine-taking behavior through the mediation of GABA receptor system.
Network Pharmacology GABA Acupuncture GABA systemResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Jujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
2020 Frontiers in Pharmacology Regulation of GABAA and 5-HT Receptors Involved in Anxiolytic Mechanisms of Jujube Seed: A System Biology Study Assisted by UPLC-Q-TOF/MS and RT-qPCR Method Chen L, Zhang X, Hu C, Zhang Y, Zhang L, Kan J, et al.
Experimental Study Anxiety Serotonin Suan Zao Ren
The research relied on a system biology method supported by Ultra Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry (UPLC-Q-TOF/MS) and Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR). Initially, 35 phytochemicals were identified from the Jujube seed extract, which related to 71 anxiolytic targets. Further investigations, including protein-protein interaction, gene cluster, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analyses, were conducted to identify the anxiolytic mechanisms of the extract.
The results highlighted that the main anxiolytic mechanisms of the Jujube seed extract were linked to the regulation of serotonergic and GABAergic synapse pathways. The extract's impact on the mRNA expressions of multiple gamma-aminobutyric acid type A (GABA) and serotonin (5-HT) receptors subtypes was verified in human neuroblastoma cells. Surprisingly, the extract (250 μg/mL) not only amplified the mRNA level of GABRA1 and GABRA3 alongside HTR1A, HTR2A, and HTR2B in untreated cells but also suppressed the overexpressed mRNA of GABRA1, GABRA2, HTR1A, and HTR2A in stress-induced cells.
Gan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
2019 Frontiers in Neuroscience GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction Chen HS, Gu LJ, Yang YX, Guo JY
Animal Study GABA Gan Mai Da Zao Tang Serotonin
The mice were given the Gan-Mai-Da-Zao (GMDZ) decoction orally at different concentrations for a week, with Diazepam and Buspirone serving as positive controls. Anxiety-level testing was conducted using a combination of the elevated plus-maze, light/dark box, marble burying, open field, and rota-rod tests, providing a comprehensive assessment of the decoction's effects on mice.
Furthermore, the anxiolytic effects that GMDZ induced in the mice were challenged by the application of Flumazenil, a gamma-aminobutyric acid-A receptor antagonist, and WAY-100635, a serotonin-1A receptor antagonist. They found that the effects were successfully inhibited, indicating that the mechanism of action of GMDZ could be linked to both the serotonin and gamma-aminobutyric acid receptors in the nervous system, thereby reducing anxiety-like behavior in mice.
Presentation Slides
Jujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A.
Gan Mai Da Zao decoction has shown comparable anxiolytic effects to Diazepam and Buspirone in mice, possibly regulated by serotonin and gamma-aminobutyric acid receptors.
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