IL-10
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Dietary supplementation with Goji berries enhances Bifidobacteria and butyrate-producing bacteria growth, resulting in potential preventative effects against colitis.
Colitis Goji Berry Gut Microbiota
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Assessment of anti-inflammatory efficacy of acupuncture in patients with inflammatory bowel disease: A systematic review and meta-analysis
2023 Jun Complementary Therapies in Medicine Yang X, He M, Tang Q, Wang Z, Jin D, Wu X, et al.
Meta-Analysis Systematic Review Acupuncture Crohn's DiseaseAcupuncture demonstrates a positive therapeutic effect on inflammatory bowel disease (IBD) by effectively regulating associated inflammatory factors.
Effect of Mediterranean Diet Enriched in High Quality Extra Virgin Olive Oil on Oxidative Stress, Inflammation and Gut Microbiota in Obese and Normal Weight Adult Subjects
2019 Nov 15 Frontiers in Pharmacology Luisi MLE, Lucarini L, Biffi B, Rafanelli E, Pietramellara G, Durante M, et al.
The Mediterranean Diet (MD) enriched with High Quality-Extra Virgin Olive Oil (HQ-EVOO) led to a significant decrease in markers of inflammation and oxidative stress, an increase in anti-inflammatory cytokines (IL-10 and adiponectin), and a substantial increase in Lactic Acid Bacteria (LAB) in the gut microbiota of overweight/obese subjects, suggesting its potential role in preventing inflammation.
Experimental Study Clinical Study Inflammation Oxidative Stress Gut MicrobiotaGoji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice
2018 Oct 07 Molecular Nutrition & Food Research Kang Y, Yang G, Zhang S, Ross CF, Zhu MJ
Experimental Study Animal Study Gut Microbiota Colitis IL-10 Goji BerryDietary supplementation with Goji berries enhances Bifidobacteria and butyrate-producing bacteria growth, resulting in potential preventative effects against colitis.
Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review
2017 Nov 03 Critical Reviews in Food Science and Nutrition Paiva CLRS, Beserra BTS, Reis CEG, Dorea JG, Da Costa THM, Amato AA
Experimental Study Systematic ReviewCoffee consumption, particularly caffeinated coffee, predominantly exhibits anti-inflammatory effects, contrasting with caffeine's complex impact on inflammation.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Acupuncture demonstrates a positive therapeutic effect on inflammatory bowel disease (IBD) by effectively regulating associated inflammatory factors.
2023 Complementary Therapies in Medicine Assessment of anti-inflammatory efficacy of acupuncture in patients with inflammatory bowel disease: A systematic review and meta-analysis Yang X, He M, Tang Q, Wang Z, Jin D, Wu X, et al.
Meta-Analysis Acupuncture Crohn's Disease
Eight electronic databases were utilized in a systematic search for studies that satisfied the pre-defined inclusion parameters. Two impartial reviewers evaluated the quality of the resultant studies and a meta-analysis was then performed to assess the efficacy of acupuncture on IBD and its related inflammatory factors which include TNF-α, IL-1, IL-8, and IL-10.
The analysis comprised of four randomized controlled trials that involved a total of 228 patients. The beneficial effects of acupuncture on IBD patients were thoroughly inspected, as well as its ability to regulate levels of specified inflammatory factors. The P values, which refer to the probability that any observed result occurred by chance, were critically assessed for every inflammatory factor - significance was found in the values of TNF-α, IL-8, and IL-10, but not for IL-1.
The conclusion drawn was that acupuncture has a positive therapeutic impact on individuals suffering from IBD, and quite importantly, can regulate inflammatory factors in these patients. As a result of these findings, it is suggested that TNF-α, IL-8, and IL-10 are the ideal inflammatory indicators for evaluating the anti-inflammatory response in this patient category.
Dietary supplementation with Goji berries enhances Bifidobacteria and butyrate-producing bacteria growth, resulting in potential preventative effects against colitis.
2018 Molecular Nutrition & Food Research Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice Kang Y, Yang G, Zhang S, Ross CF, Zhu MJ
Experimental Study Colitis Goji Berry Gut Microbiota
In this study, two groups of IL-10-deficient mice were used, with one group kept on a standard rodent diet and the other supplemented with a Goji berry diet, accounting for 1% of the dry feed's weight. These diets were maintained for 10 weeks. Colonic tissues and fecal contents were collected and analysed after this period.
In the Goji supplemented group, there was a noticeable decrease in colonic pathobiological scores, a reduced mRNA expression of Il17a and Tgfb1, and an increase in Muc1 expression and fecal IgA content. Goji supplementation was found to increase the Actinobacteria phylum, leading to a surge in Bifidobacteria in the gut microbiota. Dietary Goji also promoted the growth of butyrate-producing bacteria like the Lachnospiraceae-Ruminococcaceae family and Roseburia species under Clostridium cluster XIVa, with Clostridium leptum and Fecalibacterium prazusnitzii significantly increased in the Goji group. Interestingly, the gene encoding butyryl-coenzyme A CoA transferase, crucial for butyrate synthesis in these bacteria, showed a sixfold increase in the fecal samples from the Goji group, correlating with higher fecal butyrate levels. This phenomenon indicates that Goji berry's dietary inclusion results in Bifidobacteria proliferation and the butyrate-producing bacteria's blooming, which may have cross-feeding relationships providing preventative effects against colitis.
Coffee consumption, particularly caffeinated coffee, predominantly exhibits anti-inflammatory effects, contrasting with caffeine's complex impact on inflammation.
2017 Critical Reviews in Food Science and Nutrition Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review Paiva CLRS, Beserra BTS, Reis CEG, Dorea JG, Da Costa THM, Amato AA
Experimental Study
The study analysed 15 clinical trials concerning the impact of coffee, caffeine, or coffee components on inflammatory markers. Of these, eight focused on coffee and seven on caffeine with no regard for publication date. These trials tested, under varying conditions, the effect of coffee or caffeine consumption against placebos, or compared inflammatory marker levels before and after consumption. There was no discrimination of the used coffee's processing method, whether filtered or medium/dark roasted.
The study discovered that, out of the seven trials comparing filtered coffee/caffeinated coffee with a placebo, or comparing baseline levels versus post-consumption, adiponectin levels increased in four. On the other hand, caffeine trials showed no change. C-reactive protein (CRP) levels remained unchanged in all five studies that considered the effects of coffee. Interestingly, only one out of three trials showed decreased CPR levels in reaction to caffeine. Additionally, Interleukin (IL)-6 level increased when caffeinated coffee was compared with placebo in one out of four coffee trials and with caffeine in three out of five studies. Finally, caffeine consumption resulted in increased IL-10 levels in two out of three trials.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Assessment of anti-inflammatory efficacy of acupuncture in patients with inflammatory bowel disease: A systematic review and meta-analysis
2023 Jun Complementary Therapies in Medicine Yang X, He M, Tang Q, Wang Z, Jin D, Wu X, et al.
Meta-Analysis Systematic Review Acupuncture Crohn's DiseaseAcupuncture demonstrates a positive therapeutic effect on inflammatory bowel disease (IBD) by effectively regulating associated inflammatory factors.
Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review
2017 Nov 03 Critical Reviews in Food Science and Nutrition Paiva CLRS, Beserra BTS, Reis CEG, Dorea JG, Da Costa THM, Amato AA
Experimental Study Systematic ReviewCoffee consumption, particularly caffeinated coffee, predominantly exhibits anti-inflammatory effects, contrasting with caffeine's complex impact on inflammation.
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Presentation Slides
Meta-Analysis
Acupuncture demonstrates a positive therapeutic effect on inflammatory bowel disease (IBD) by effectively regulating associated inflammatory factors.
Yang X, He M, Tang Q, Wang Z, Jin D, Wu X, Yang Y, Ma D, Sun M, Li T
Experimental Study
Dietary supplementation with Goji berries enhances Bifidobacteria and butyrate-producing bacteria growth, resulting in potential preventative effects against colitis.
Kang Y, Yang G, Zhang S, Ross CF, Zhu MJ
Experimental Study
Coffee consumption, particularly caffeinated coffee, predominantly exhibits anti-inflammatory effects, contrasting with caffeine's complex impact on inflammation.
Paiva CLRS, Beserra BTS, Reis CEG, Dorea JG, Da Costa THM, Amato AA
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for IL-10" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for IL-10" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for IL-10" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Meta-Analysis published in 2023 in the journal Complementary Therapies in Medicine found that Acupuncture demonstrates a positive therapeutic effect on inflammatory bowel disease (IBD) by effectively regulating associated inflammatory factors. Eight electronic databases were utilized in a systematic search for studies that satisfied the pre-defined inclusion parameters. Two impartial reviewers evaluated the quality of the resultant studies and a meta-analysis was then performed to assess the efficacy of acupuncture on IBD and its related inflammatory factors which include TNF-α, IL-1, IL-8, and IL-10. The analysis comprised of four randomized controlled trials that involved a total of 228 patients. The beneficial effects of acupuncture on IBD patients were thoroughly inspected, as well as its ability to regulate levels of specified inflammatory factors. The P values, which refer to the probability that any observed result occurred by chance, were critically assessed for every inflammatory factor - significance was found in the values of TNF-α, IL-8, and IL-10, but not for IL-1. The conclusion drawn was that acupuncture has a positive therapeutic impact on individuals suffering from IBD, and quite importantly, can regulate inflammatory factors in these patients. As a result of these findings, it is suggested that TNF-α, IL-8, and IL-10 are the ideal inflammatory indicators for evaluating the anti-inflammatory response in this patient category.
A Experimental Study published in 2018 in the journal Molecular Nutrition & Food Research found that Dietary supplementation with Goji berries enhances Bifidobacteria and butyrate-producing bacteria growth, resulting in potential preventative effects against colitis. In this study, two groups of IL-10-deficient mice were used, with one group kept on a standard rodent diet and the other supplemented with a Goji berry diet, accounting for 1% of the dry feed's weight. These diets were maintained for 10 weeks. Colonic tissues and fecal contents were collected and analysed after this period. In the Goji supplemented group, there was a noticeable decrease in colonic pathobiological scores, a reduced mRNA expression of Il17a and Tgfb1, and an increase in Muc1 expression and fecal IgA content. Goji supplementation was found to increase the Actinobacteria phylum, leading to a surge in Bifidobacteria in the gut microbiota. Dietary Goji also promoted the growth of butyrate-producing bacteria like the Lachnospiraceae-Ruminococcaceae family and Roseburia species under Clostridium cluster XIVa, with Clostridium leptum and Fecalibacterium prazusnitzii significantly increased in the Goji group. Interestingly, the gene encoding butyryl-coenzyme A CoA transferase, crucial for butyrate synthesis in these bacteria, showed a sixfold increase in the fecal samples from the Goji group, correlating with higher fecal butyrate levels. This phenomenon indicates that Goji berry's dietary inclusion results in Bifidobacteria proliferation and the butyrate-producing bacteria's blooming, which may have cross-feeding relationships providing preventative effects against colitis.
A Experimental Study published in 2017 in the journal Critical Reviews in Food Science and Nutrition found that Coffee consumption, particularly caffeinated coffee, predominantly exhibits anti-inflammatory effects, contrasting with caffeine's complex impact on inflammation. The study analysed 15 clinical trials concerning the impact of coffee, caffeine, or coffee components on inflammatory markers. Of these, eight focused on coffee and seven on caffeine with no regard for publication date. These trials tested, under varying conditions, the effect of coffee or caffeine consumption against placebos, or compared inflammatory marker levels before and after consumption. There was no discrimination of the used coffee's processing method, whether filtered or medium/dark roasted. The study discovered that, out of the seven trials comparing filtered coffee/caffeinated coffee with a placebo, or comparing baseline levels versus post-consumption, adiponectin levels increased in four. On the other hand, caffeine trials showed no change. C-reactive protein (CRP) levels remained unchanged in all five studies that considered the effects of coffee. Interestingly, only one out of three trials showed decreased CPR levels in reaction to caffeine. Additionally, Interleukin (IL)-6 level increased when caffeinated coffee was compared with placebo in one out of four coffee trials and with caffeine in three out of five studies. Finally, caffeine consumption resulted in increased IL-10 levels in two out of three trials.
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