Immunomodulation
Recent Insights
Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
Honey Immunomodulation
The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.
Antioxidant Immunomodulation
Goji berries, rich in antioxidants, confer health benefits including protection against aging, cancer, and radiation, as well as enhancing immunity and blood production.
Antioxidant Immunomodulation
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Research Articles
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Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
2023 Apr 04 Nutrients Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, Gutiérrez-Brito JA, Díaz-Pérez SA, Aguayo-Arelis A, et al.
Review Article Depression SuicideVitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
Characterization of immunomodulatory responses induced by manuka honey
2022 Nov 02 Frontiers in Immunology Masad RJ, Nasser RA, Bashir G, Mohamed YA, Al-Sbiei A, Al-Saafeen BH, et al.
Network Pharmacology Animal Study Immunomodulation HoneyManuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
Acupuncture modulates immunity in sepsis: Toward a science-based protocol
2021 May 1 Autonomic Neuroscience: Basic and Clinical Pan WX, Fan AY, Chen S, Alemi SF.
Review Article Experimental Study ImmunityAcupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review
2021 Mar Journal of Ethnopharmacology Liu H, Wang ZY, Zhou YC, Song W, Ali U, Sze DMY
This comprehensive review demonstrated NK cells activity was positively associated with quality of life but not survival benefit of cancer patients. Thus exploring the roles of NK cells in adjuvant therapy against cancer is confirmed to be beneficial to explore the underlying relationship between immunomodulation and quality of life.
Systematic ReviewIntegrated metabolomics and network pharmacology approach to reveal immunomodulatory mechanisms of Yupingfeng granules
2021 Feb Journal of Pharmaceutical and Biomedical Analysis Li M, Gao Y, Yue X, Zhang B, Zhou H, Yuan C, et al.
YPFG influences the metabolism of bile acids and phospholipids. Flavonoids and saponins in YPFG were the main active components responsible for its immune-modulating effects. These components improved bile acid metabolism by enhancing the expression of certain proteins.
Network Pharmacology ImmunomodulationResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Vitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
2023 Nutrients Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, Gutiérrez-Brito JA, Díaz-Pérez SA, Aguayo-Arelis A, et al.
Review Article Depression Suicide
The paper examines the links between vitamin D deficiency, depression, and suicide from various studies. It hypothesizes that vitamin D could enhance serotonin synthesis and modulate proinflammatory cytokines, both factors in depression and suicide. The paper reviews this hypothesis in the context of the broader health issue of suicide, which is among the leading causes of death worldwide.
This paper then discusses the potential benefits of vitamin D supplementation. Drawing upon indirect evidence suggesting that vitamin D deficiencies may be a risk factor for depression—one of the most common factors in suicide attempts—the paper postulates that vitamin D supplementation could play a role in helping to reduce the risk of depression and thus suicide. The beneficial mechanisms of vitamin D, such as enhancing serotonin synthesis and modulating proinflammatory cytokines, which are associated with depression and suicide, stand as the central contributing factors in this hypothesis.
Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
2022 Frontiers in Immunology Characterization of immunomodulatory responses induced by manuka honey Masad RJ, Nasser RA, Bashir G, Mohamed YA, Al-Sbiei A, Al-Saafeen BH, et al.
Network Pharmacology Honey
In vitro experiments using RAW 264.7 macrophages demonstrated that 1% Manuka honey significantly upregulated the expression and secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and iNOS, as well as chemokines such as CXCL2 and CCL2. In vivo studies with C57BL/6 mice revealed a robust peritoneal response characterized by increased neutrophil recruitment and phenotypic changes in peritoneal macrophages after intraperitoneal administration of Manuka honey. Notably, this response persisted in TLR4-defective mice, suggesting independence from TLR4 and ruling out LPS contamination. However, the dependence on MyD88 protein, a crucial adaptor in TLR signaling, was evident, shedding light on the immunostimulatory properties of Manuka honey and its potential as an immunomodulatory agent in diverse disorders.
The study delineates Manuka honey's immunomodulatory actions, showcasing its pro-inflammatory impact through cytokine release and neutrophil recruitment, independent of TLR4 but reliant on MyD88 signaling. Additionally, the observed phenotypic alterations in macrophages underscore the potential utility of Manuka honey as an immunomodulatory agent across various health conditions, offering insights into its complex yet promising role in immune regulation.
Acupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
2021 Autonomic Neuroscience: Basic and Clinical Acupuncture modulates immunity in sepsis: Toward a science-based protocol Pan WX, Fan AY, Chen S, Alemi SF.
Review Article Immunity
The study used a neuromodulation approach, leveraging the technique of peripheral nerve stimulation through acupuncture. This was linked with known somatic-autonomous-immune reflexes with the aim to control inflammation and improve organ functions in sepsis cases. The local and systematic effects of this methodology were largely achieved through the activation of several reflexes. These included the somatic-sympathetic-splenic reflex, the somatic-sympathic-adrenal reflex, the somatic-vagal-splenic reflex, and the somatic-vagal-adrenal reflex. The activation of these particular reflexes is what sets acupuncture apart from other nerve stimulation techniques.
In terms of results, the method used for immunomodulation and inflammation control showed considerable promise for sepsis treatment. The acupuncture procedure achieved regulation by activating appropriate reflexes which in turn produced a systemic effect, thereby controlling inflammation and enhancing organ function. The research findings underscore acupuncture as an effective therapy, providing significant advantages for immunomodulation in acute inflammation such as sepsis, leading to a comprehensive, evidence-based therapy recommendation.
Tremella fuciformis polysaccharide, a major bioactive component in the edible medicinal mushroom, exhibits substantial health benefits, including enhancing the immune system, combatting tumors, and delaying aging.
2019 Progress in Molecular Biology and Translational Science Tremella polysaccharide: The molecular mechanisms of its drug action Yang D, Liu Y, Zhang L.
Network Pharmacology Snow Fungus
The study analyzed various fractions of Tremella fuciformis polysaccharide (TFPS) which is extracted from the "Yiner" mushroom under different conditions leading to variations in molecular weight. The TFPS comprises various monosaccharides including mannose, xylose, fucose, glucuronic acid, glucose, and galactose. One of the characterized structures consists of a linear mannose backbone with branched off chains of xylose, fucose and glucuronic acid. Biochemical, pharmacological, and clinical studies involving TFPS spanning 46 years (1972-2018) were drawn from the likes of PubMed, China National Knowledge Infrastructure and Wanfang database and comprehensively reviewed.
Over one hundred independent studies pointed to the multiple physiological and health-promoting effects of TFPS. These include benefits such as immunomodulation, antitumor, anti-oxidation, anti-aging, hypoglycemic, and hypolipidemic effects. An example of its practical application is its usage in enteric-coated capsules, approved by the Chinese Food and Drug Administration in 2002, to treat cancer patients suffering from leukopenia induced by chemotherapy and radiotherapy. This component is also used as a supplementary drug for the treatment of chronic persistent hepatitis and chronic active hepatitis, showing the versatility and progressive impact of TFPS.
The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.
2019 Oxidative Medicine and Cellular Longevity Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action Zheng Feei Ma, Hongxia Zhang, Sue Siang Teh, Chee Woon Wang, Yutong Zhang, Frank Hayford, et al.
Systematic Review Antioxidant
Goji berries are a high antioxidant potential fruits which alleviate oxidative stress to confer many health protective benefits such as preventing free radicals from damaging DNA, lipids, and proteins. There is a better protection through synergistic and additive effects in fruits and herbal products from a complex mixture of phytochemicals than from a single phytochemical. The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
2023 Apr 04 Nutrients Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, Gutiérrez-Brito JA, Díaz-Pérez SA, Aguayo-Arelis A, et al.
Review Article Depression SuicideVitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
Acupuncture modulates immunity in sepsis: Toward a science-based protocol
2021 May 1 Autonomic Neuroscience: Basic and Clinical Pan WX, Fan AY, Chen S, Alemi SF.
Review Article Experimental Study ImmunityAcupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review
2021 Mar Journal of Ethnopharmacology Liu H, Wang ZY, Zhou YC, Song W, Ali U, Sze DMY
This comprehensive review demonstrated NK cells activity was positively associated with quality of life but not survival benefit of cancer patients. Thus exploring the roles of NK cells in adjuvant therapy against cancer is confirmed to be beneficial to explore the underlying relationship between immunomodulation and quality of life.
Systematic ReviewThe Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders
2020 Sep 11 International Journal of Molecular Sciences Szymczak-Pajor I, Drzewoski J, Śliwińska A
Vitamin D is also involved in a great number of cellular processes responsible for the homeostasis of glucose and lipid metabolism via insulin signaling pathway. Considering multiple targets of vitamin D, we propose that pleiotropic action of vitamin D is a result of the crosstalk between insulin signaling and other signaling pathways governing metabolism, inflammation, immunomodulation, apoptosis, and adipogenesis.
Review ArticleImpact of soy consumption on human health: integrative review
2020 Jan Brazilian Journal of Food Technology Nogueira-de-Almeida CA, Ferraz IS, Ued FV, Almeida ACF, Ciampo LAD
The integrative review on soy consumption and its effects on human health, based on 97 selected studies, provides insights into various aspects including its impact on protein quality, early exposure using soy formulas, and effects on conditions such as breast cancer, endometrial and ovarian cancer, prostate cancer, cardiovascular disease, glucose metabolism, type 2 diabetes, obesity, reproductive health, menopause, osteoporosis, microbiota, immunity, immunomodulation, thyroid function, attention-deficit hyperactivity disorder, and renal function.
Review Article SoybeanClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Review Article
Vitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, Gutiérrez-Brito JA, Díaz-Pérez SA, Aguayo-Arelis A, Hernández-Bello J
Network Pharmacology
Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
Masad RJ, Nasser RA, Bashir G, Mohamed YA, Al-Sbiei A, Al-Saafeen BH, Fernandez-Cabezudo MJ, Al-Ramadi BK
Review Article
Acupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
Pan WX, Fan AY, Chen S, Alemi SF.
Network Pharmacology
Tremella fuciformis polysaccharide, a major bioactive component in the edible medicinal mushroom, exhibits substantial health benefits, including enhancing the immune system, combatting tumors, and delaying aging.
Yang D, Liu Y, Zhang L.
Systematic Review
The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.
Zheng Feei Ma, Hongxia Zhang, Sue Siang Teh, Chee Woon Wang, Yutong Zhang, Frank Hayford, Liuyi Wang, Tong Ma, Zihan Dong, Yan Zhang, Yifan Zhu,
Systematic Review
Goji berries, rich in antioxidants, confer health benefits including protection against aging, cancer, and radiation, as well as enhancing immunity and blood production.
Zheng Feei Ma, Hongxia Zhang, Sue Siang Teh, Chee Woon Wang, Yutong Zhang, Frank Hayford, Liuyi Wang, Tong Ma, Zihan Dong, Yan Zhang, Yifan Zhu,
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Immunomodulation" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Immunomodulation" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Immunomodulation" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Review Article published in 2023 in the journal Nutrients found that Vitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects. The paper examines the links between vitamin D deficiency, depression, and suicide from various studies. It hypothesizes that vitamin D could enhance serotonin synthesis and modulate proinflammatory cytokines, both factors in depression and suicide. The paper reviews this hypothesis in the context of the broader health issue of suicide, which is among the leading causes of death worldwide. This paper then discusses the potential benefits of vitamin D supplementation. Drawing upon indirect evidence suggesting that vitamin D deficiencies may be a risk factor for depression—one of the most common factors in suicide attempts—the paper postulates that vitamin D supplementation could play a role in helping to reduce the risk of depression and thus suicide. The beneficial mechanisms of vitamin D, such as enhancing serotonin synthesis and modulating proinflammatory cytokines, which are associated with depression and suicide, stand as the central contributing factors in this hypothesis.
A Network Pharmacology published in 2022 in the journal Frontiers in Immunology found that Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages. In vitro experiments using RAW 264.7 macrophages demonstrated that 1% Manuka honey significantly upregulated the expression and secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and iNOS, as well as chemokines such as CXCL2 and CCL2. In vivo studies with C57BL/6 mice revealed a robust peritoneal response characterized by increased neutrophil recruitment and phenotypic changes in peritoneal macrophages after intraperitoneal administration of Manuka honey. Notably, this response persisted in TLR4-defective mice, suggesting independence from TLR4 and ruling out LPS contamination. However, the dependence on MyD88 protein, a crucial adaptor in TLR signaling, was evident, shedding light on the immunostimulatory properties of Manuka honey and its potential as an immunomodulatory agent in diverse disorders. The study delineates Manuka honey's immunomodulatory actions, showcasing its pro-inflammatory impact through cytokine release and neutrophil recruitment, independent of TLR4 but reliant on MyD88 signaling. Additionally, the observed phenotypic alterations in macrophages underscore the potential utility of Manuka honey as an immunomodulatory agent across various health conditions, offering insights into its complex yet promising role in immune regulation.
A Review Article published in 2021 in the journal Autonomic Neuroscience: Basic and Clinical found that Acupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes. The study used a neuromodulation approach, leveraging the technique of peripheral nerve stimulation through acupuncture. This was linked with known somatic-autonomous-immune reflexes with the aim to control inflammation and improve organ functions in sepsis cases. The local and systematic effects of this methodology were largely achieved through the activation of several reflexes. These included the somatic-sympathetic-splenic reflex, the somatic-sympathic-adrenal reflex, the somatic-vagal-splenic reflex, and the somatic-vagal-adrenal reflex. The activation of these particular reflexes is what sets acupuncture apart from other nerve stimulation techniques. In terms of results, the method used for immunomodulation and inflammation control showed considerable promise for sepsis treatment. The acupuncture procedure achieved regulation by activating appropriate reflexes which in turn produced a systemic effect, thereby controlling inflammation and enhancing organ function. The research findings underscore acupuncture as an effective therapy, providing significant advantages for immunomodulation in acute inflammation such as sepsis, leading to a comprehensive, evidence-based therapy recommendation.
A Network Pharmacology published in 2019 in the journal Progress in Molecular Biology and Translational Science found that Tremella fuciformis polysaccharide, a major bioactive component in the edible medicinal mushroom, exhibits substantial health benefits, including enhancing the immune system, combatting tumors, and delaying aging. The study analyzed various fractions of Tremella fuciformis polysaccharide (TFPS) which is extracted from the "Yiner" mushroom under different conditions leading to variations in molecular weight. The TFPS comprises various monosaccharides including mannose, xylose, fucose, glucuronic acid, glucose, and galactose. One of the characterized structures consists of a linear mannose backbone with branched off chains of xylose, fucose and glucuronic acid. Biochemical, pharmacological, and clinical studies involving TFPS spanning 46 years (1972-2018) were drawn from the likes of PubMed, China National Knowledge Infrastructure and Wanfang database and comprehensively reviewed. Over one hundred independent studies pointed to the multiple physiological and health-promoting effects of TFPS. These include benefits such as immunomodulation, antitumor, anti-oxidation, anti-aging, hypoglycemic, and hypolipidemic effects. An example of its practical application is its usage in enteric-coated capsules, approved by the Chinese Food and Drug Administration in 2002, to treat cancer patients suffering from leukopenia induced by chemotherapy and radiotherapy. This component is also used as a supplementary drug for the treatment of chronic persistent hepatitis and chronic active hepatitis, showing the versatility and progressive impact of TFPS.
A Systematic Review published in 2019 in the journal Oxidative Medicine and Cellular Longevity found that The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation. Goji berries are a high antioxidant potential fruits which alleviate oxidative stress to confer many health protective benefits such as preventing free radicals from damaging DNA, lipids, and proteins. There is a better protection through synergistic and additive effects in fruits and herbal products from a complex mixture of phytochemicals than from a single phytochemical. The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.
A Systematic Review published in 2019 in the journal Oxidative Medicine and Cellular Longevity found that Goji berries, rich in antioxidants, confer health benefits including protection against aging, cancer, and radiation, as well as enhancing immunity and blood production. The methodology of the study focused on a thorough review of the bioactive compounds and pharmacological properties of goji berries, particularly targeting their molecular mechanisms of action. This involved looking at the different ways these fruits are consumed, such as in soups, herbal teas, tinctures, wine, and juice, and how these methods influence the antioxidants present in the fruits. Goji berries were found to offer a range of health benefits due to their ability to alleviate oxidative stress. These benefits include enhancing hemopoiesis (blood formation), offering antiradiation and antiaging properties, inhibiting cancer, improving immunity, and providing antioxidation. Furthermore, the study emphasized that the complex mixture of phytochemicals found in fruits and herbal products like goji berries provide a cumulative protective effect, which proves more beneficial compared to extracting and using one single phytochemical.
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