Immunomodulation
Recent Insights
Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
Honey Immunomodulation
Carrot's bioactive compounds can regulate immune response, reduce oxidative stress, and prevent damaging oxidative destruction, making it a potential preventive tool for various diseases.
Anti-Inflammatory Carotene Carrot
Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.
Anti-Inflammatory Antiviral COVID-19
Honey's phytochemical components and bioactive compounds have potential antiviral effects, potentially making it an effective natural product against COVID-19.
Antiviral COVID-19 Honey
The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.
Anti-Ageing Anticancer Antioxidant
Goji berries, rich in antioxidants, confer health benefits including protection against aging, cancer, and radiation, as well as enhancing immunity and blood production.
Anti-Ageing Anticancer Antioxidant
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
2023 Apr 04 Nutrients Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, Gutiérrez-Brito JA, Díaz-Pérez SA, Aguayo-Arelis A, et al.
Review Article Depression SuicideVitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
2022 Dec Journal of Functional Foods Anjani G, Ayustaningwarno F, Eviana R
Review Article Anti-Inflammatory Immunomodulation Carotene Oxidative Stress CarrotCarrot's bioactive compounds can regulate immune response, reduce oxidative stress, and prevent damaging oxidative destruction, making it a potential preventive tool for various diseases.
Characterization of immunomodulatory responses induced by manuka honey
2022 Nov 02 Frontiers in Immunology Masad RJ, Nasser RA, Bashir G, Mohamed YA, Al-Sbiei A, Al-Saafeen BH, et al.
Network Pharmacology Animal Study Immunomodulation HoneyManuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
Acupuncture modulates immunity in sepsis: Toward a science-based protocol
2021 May 1 Autonomic Neuroscience: Basic and Clinical Pan WX, Fan AY, Chen S, Alemi SF.
Review Article Experimental Study Common Cold, Flu & Viral Infections Sepsis ImmunityAcupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review
2021 Mar Journal of Ethnopharmacology Liu H, Wang ZY, Zhou YC, Song W, Ali U, Sze DMY
This comprehensive review demonstrated NK cells activity was positively associated with quality of life but not survival benefit of cancer patients. Thus exploring the roles of NK cells in adjuvant therapy against cancer is confirmed to be beneficial to explore the underlying relationship between immunomodulation and quality of life.
Systematic Review CancerResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Vitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
2023 Nutrients Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, Gutiérrez-Brito JA, Díaz-Pérez SA, Aguayo-Arelis A, et al.
Review Article Depression Suicide
The paper examines the links between vitamin D deficiency, depression, and suicide from various studies. It hypothesizes that vitamin D could enhance serotonin synthesis and modulate proinflammatory cytokines, both factors in depression and suicide. The paper reviews this hypothesis in the context of the broader health issue of suicide, which is among the leading causes of death worldwide.
This paper then discusses the potential benefits of vitamin D supplementation. Drawing upon indirect evidence suggesting that vitamin D deficiencies may be a risk factor for depression—one of the most common factors in suicide attempts—the paper postulates that vitamin D supplementation could play a role in helping to reduce the risk of depression and thus suicide. The beneficial mechanisms of vitamin D, such as enhancing serotonin synthesis and modulating proinflammatory cytokines, which are associated with depression and suicide, stand as the central contributing factors in this hypothesis.
Carrot's bioactive compounds can regulate immune response, reduce oxidative stress, and prevent damaging oxidative destruction, making it a potential preventive tool for various diseases.
2022 Journal of Functional Foods Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds Anjani G, Ayustaningwarno F, Eviana R
Review Article Anti-Inflammatory Carotene Carrot
In this literature review, mechanisms were proposed for how the antioxidant properties of carrot’s β-carotene and other bioactive compounds, such as phenolic acid, flavonoid, polyacetylene, and ascorbic acid could modulate the immune system. These proposals were centered around three main paths: anti-inflammatory response modulation, antioxidant response modulation, and overall immune response modulation (which involves both innate and adaptive responses).
In the discussion of results, it was revealed that the bioactive compounds in carrots have the ability to regulate pro-inflammatory and anti-inflammatory cytokines, and are also capable of reducing oxidative stress. This was shown by the decrease in the accumulation of reactive oxygen species and an increase in antioxidant capacity, which collaboratively helps to minimize destructive oxidative destruction. Additionally, these compounds influenced immune components, specifically via the regulation of leukocytes, antigens, immunoglobulins, and histamine levels. As a result, carrots were defined as a functional food source capable of immune modulation and potential prevention and treatment for a range of diseases.
Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
2022 Frontiers in Immunology Characterization of immunomodulatory responses induced by manuka honey Masad RJ, Nasser RA, Bashir G, Mohamed YA, Al-Sbiei A, Al-Saafeen BH, et al.
Network Pharmacology Honey
In vitro experiments using RAW 264.7 macrophages demonstrated that 1% Manuka honey significantly upregulated the expression and secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and iNOS, as well as chemokines such as CXCL2 and CCL2. In vivo studies with C57BL/6 mice revealed a robust peritoneal response characterized by increased neutrophil recruitment and phenotypic changes in peritoneal macrophages after intraperitoneal administration of Manuka honey. Notably, this response persisted in TLR4-defective mice, suggesting independence from TLR4 and ruling out LPS contamination. However, the dependence on MyD88 protein, a crucial adaptor in TLR signaling, was evident, shedding light on the immunostimulatory properties of Manuka honey and its potential as an immunomodulatory agent in diverse disorders.
The study delineates Manuka honey's immunomodulatory actions, showcasing its pro-inflammatory impact through cytokine release and neutrophil recruitment, independent of TLR4 but reliant on MyD88 signaling. Additionally, the observed phenotypic alterations in macrophages underscore the potential utility of Manuka honey as an immunomodulatory agent across various health conditions, offering insights into its complex yet promising role in immune regulation.
Acupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
2021 Autonomic Neuroscience: Basic and Clinical Acupuncture modulates immunity in sepsis: Toward a science-based protocol Pan WX, Fan AY, Chen S, Alemi SF.
Review Article Common Cold, Flu & Viral Infections Immunity Sepsis
The study used a neuromodulation approach, leveraging the technique of peripheral nerve stimulation through acupuncture. This was linked with known somatic-autonomous-immune reflexes with the aim to control inflammation and improve organ functions in sepsis cases. The local and systematic effects of this methodology were largely achieved through the activation of several reflexes. These included the somatic-sympathetic-splenic reflex, the somatic-sympathic-adrenal reflex, the somatic-vagal-splenic reflex, and the somatic-vagal-adrenal reflex. The activation of these particular reflexes is what sets acupuncture apart from other nerve stimulation techniques.
In terms of results, the method used for immunomodulation and inflammation control showed considerable promise for sepsis treatment. The acupuncture procedure achieved regulation by activating appropriate reflexes which in turn produced a systemic effect, thereby controlling inflammation and enhancing organ function. The research findings underscore acupuncture as an effective therapy, providing significant advantages for immunomodulation in acute inflammation such as sepsis, leading to a comprehensive, evidence-based therapy recommendation.
Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.
2021 Molecules Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies Ali AM, Kunugi H
Review Article Anti-Inflammatory Antiviral COVID-19
The study's methodology involved a comprehensive review of the literature on the potential anti-COVID-19 effects of bee honey and propolis, products known for their strong antimicrobial and antioxidant abilities. The researchers conducted molecular simulations to see how various flavonoids found in these products might inhibit essential viral processes. Additionally, they compared the effectiveness of propolis extracts delivered by nanocarriers to ethanolic extracts, and they examined the effects of a combination of honey and propolis on hospitalized COVID-19 patients.
The findings from the review and simulations suggested that certain flavonoids in honey and propolis may inhibit the fusion of the virus spike with host cells, interactions that cause a cytokine storm, and viral replication. Propolis ethanolic extract, rutin, and propolis liposomes displayed inhibitory action against non-structural proteins of the virus in vitro while naringin inhibited viral infection in specific cells. When delivered via nanocarriers, propolis extracts showed enhanced antiviral effects against the virus compared to ethanolic extracts. Observations of hospitalized patients suggested that those treated with green Brazilian propolis or a honey-propolis combination experienced quicker viral clearance, symptom recovery, and hospital discharge, along with lower mortality rates.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
2023 Apr 04 Nutrients Somoza-Moncada MM, Turrubiates-Hernández FJ, Muñoz-Valle JF, Gutiérrez-Brito JA, Díaz-Pérez SA, Aguayo-Arelis A, et al.
Review Article Depression SuicideVitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
2022 Dec Journal of Functional Foods Anjani G, Ayustaningwarno F, Eviana R
Review Article Anti-Inflammatory Immunomodulation Carotene Oxidative Stress CarrotCarrot's bioactive compounds can regulate immune response, reduce oxidative stress, and prevent damaging oxidative destruction, making it a potential preventive tool for various diseases.
Acupuncture modulates immunity in sepsis: Toward a science-based protocol
2021 May 1 Autonomic Neuroscience: Basic and Clinical Pan WX, Fan AY, Chen S, Alemi SF.
Review Article Experimental Study Common Cold, Flu & Viral Infections Sepsis ImmunityAcupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review
2021 Mar Journal of Ethnopharmacology Liu H, Wang ZY, Zhou YC, Song W, Ali U, Sze DMY
This comprehensive review demonstrated NK cells activity was positively associated with quality of life but not survival benefit of cancer patients. Thus exploring the roles of NK cells in adjuvant therapy against cancer is confirmed to be beneficial to explore the underlying relationship between immunomodulation and quality of life.
Systematic Review CancerPropolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies
2021 Feb 25 Molecules Ali AM, Kunugi H
Review Article Antiviral Immunomodulation Anti-Inflammatory COVID-19 HoneyBee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.
Presentation Slides
Vitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects.
Carrot's bioactive compounds can regulate immune response, reduce oxidative stress, and prevent damaging oxidative destruction, making it a potential preventive tool for various diseases.
Manuka honey exhibits a dual role in immune modulation, triggering a pro-inflammatory response by elevating cytokine expression and neutrophil recruitment via TLR signaling, while also influencing the phenotypic and functional maturation of macrophages.
Acupuncture, via nerve stimulation, can be a promising treatment strategy for controlling inflammation and improving organ function during sepsis by activating immune reflexes.
Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.
Honey's phytochemical components and bioactive compounds have potential antiviral effects, potentially making it an effective natural product against COVID-19.
Tremella fuciformis polysaccharide, a major bioactive component in the edible medicinal mushroom, exhibits substantial health benefits, including enhancing the immune system, combatting tumors, and delaying aging.
The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.
Goji berries, rich in antioxidants, confer health benefits including protection against aging, cancer, and radiation, as well as enhancing immunity and blood production.
Recent phytochemical studies of jujube fruits have shed some light on their biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, and gastrointestinal protective activities and inhibition of foam cell formation in macrophages.
Curcumin, a component of Indian spice turmeric, presents a potential natural treatment for depression, influencing neurotransmitters and protecting against several biological systems compromised in depression.
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