Intestinal Inflammation
Recent Insights
Pu-erh tea may prevent circadian rhythm disorders by promoting tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
Cholesterol Intestinal Inflammation Pu-Erh Tea
Two French natural mineral waters (NMW1 and NMW2) show anti-inflammatory effects and can reduce intestinal inflammation in mice with induced colitis.
Colitis Digestive Health Gut Microbiota
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism
2022 Apr 27 Journal of Agricultural and Food Chemistry Hu S, Luo L, Bian X, Liu RH, Zhao S, Chen Y, et al.
Experimental Study Animal Study Cholesterol Intestinal Inflammation Pu-Erh TeaPu-erh tea may prevent circadian rhythm disorders by promoting tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis
2022 Mar 07 Frontiers in Pharmacology Hu Y, Ye Z, She Y, Li L, Wu M, Qin K, et al.
The combination of probiotics with TCM demonstrates superior efficacy compared to 5-aminosalicylic acid (5-ASA), probiotics alone, or TCM alone in managing UC. This approach effectively controls clinical symptoms, reduces intestinal inflammation, and lowers recurrence rates with minimal adverse events. Utilizing a mixture of different probiotics alongside individually tailored TCM appears to be a promising clinical strategy for UC treatment.
Meta-Analysis Systematic Review Probiotic Crohn's DiseaseBeneficial Effects of Natural Mineral Waters on Intestinal Inflammation and the Mucosa-Associated Microbiota
2021 Apr 21 International Journal of Molecular Sciences Barnich N, Rodrigues M, Sauvanet P, Chevarin C, Denis S, Le Goff O, et al.
Experimental Study Animal Study Mineral Water Intestinal Inflammation Digestive Health Gut Microbiota ColitisTwo French natural mineral waters (NMW1 and NMW2) show anti-inflammatory effects and can reduce intestinal inflammation in mice with induced colitis.
Selenium and inflammatory bowel disease
2015 Jul 15 American Journal of Physiology-Gastrointestinal and Liver Physiology Kudva AK, Shay AE, Prabhu KS
Selenium, incorporated into selenoproteins, plays a pivotal role in the modulation of gastrointestinal inflammation by influencing macrophage function and driving a switch from a proinflammatory to an anti-inflammatory phenotype. This phenotypic plasticity, accompanied by changes in cytokines, chemokines, and bioactive metabolites, contributes to the resolution of inflammation in the gut and restoration of epithelial barrier integrity. The review highlights the importance of selenium-dependent regulation of arachidonic acid metabolism and emphasizes the role of macrophages in supporting resolution in IBD.
Theoretical Article Review Article Irritable Bowel Syndrome SeleniumResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Pu-erh tea may prevent circadian rhythm disorders by promoting tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
2022 Journal of Agricultural and Food Chemistry Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism Hu S, Luo L, Bian X, Liu RH, Zhao S, Chen Y, et al.
Experimental Study Cholesterol Pu-Erh Tea
Healthy mice were administered water or 0.25% Pu-erh tea over a period of seven weeks, and then subjected to a disruption of their light/dark cycle for forty days. The assessment of effects was based on changes in neurotransmitter secretion and gene oscillations, intestinal inflammation, and the balance of intestinal microbes and metabolites.
Results indicated that Pu-erh tea had beneficial impacts in regulating neurotransmitter secretion and clock gene oscillations, especially indole and 5-hydroxytryptamine pathways, a key process involving the gut-liver-brain axis. Moreover, the tea's metabolites improved release of brain hormones, thus enhancing hepatic glycolipid metabolism and lowering intestinal oxidative stress. Further observed beneficial effects included promotion of liver lipid metabolism and reduction of intestinal inflammation, via the enterohepatic circulation.
Two French natural mineral waters (NMW1 and NMW2) show anti-inflammatory effects and can reduce intestinal inflammation in mice with induced colitis.
2021 International Journal of Molecular Sciences Beneficial Effects of Natural Mineral Waters on Intestinal Inflammation and the Mucosa-Associated Microbiota Barnich N, Rodrigues M, Sauvanet P, Chevarin C, Denis S, Le Goff O, et al.
Experimental Study Colitis Digestive Health Gut Microbiota
The study investigated the anti-inflammatory effects of two French natural mineral waters (NMWs) - NMW1 (rich in calcium, magnesium, sodium, carbon, and iron) and NMW2 (mainly bicarbonate) - on intestinal inflammation. Intestinal epithelial cells were stimulated with heat-inactivated Escherichia coli or hydrogen peroxide and then treated with NMWs. Additionally, moderate colitis was induced in Balbc/J mice using 1% dextran sulfate sodium. These mice were then given either NMW1, NMW2, or control water. The study assessed general symptoms, histological features of colitis, fecal lipocalin-2 levels, pro-inflammatory KC cytokine levels, and the global mucosa-associated microbiota.
Both NMW1 and NMW2 showed anti-inflammatory effects in treated intestinal cells. In the colitis-induced mice, NMW1 notably reduced inflammation, evidenced by lower disease activity scores, reduced fecal lipocalin-2, decreased release of pro-inflammatory KC cytokines, and smaller intestinal epithelial lesions. NMW1 also helped in maintaining the normal state of mucosa-associated microbiota. These findings suggest the potential of these NMWs in managing inflammatory bowel disease through modulating gut microbiota.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis
2022 Mar 07 Frontiers in Pharmacology Hu Y, Ye Z, She Y, Li L, Wu M, Qin K, et al.
The combination of probiotics with TCM demonstrates superior efficacy compared to 5-aminosalicylic acid (5-ASA), probiotics alone, or TCM alone in managing UC. This approach effectively controls clinical symptoms, reduces intestinal inflammation, and lowers recurrence rates with minimal adverse events. Utilizing a mixture of different probiotics alongside individually tailored TCM appears to be a promising clinical strategy for UC treatment.
Meta-Analysis Systematic Review Probiotic Crohn's DiseaseSelenium and inflammatory bowel disease
2015 Jul 15 American Journal of Physiology-Gastrointestinal and Liver Physiology Kudva AK, Shay AE, Prabhu KS
Selenium, incorporated into selenoproteins, plays a pivotal role in the modulation of gastrointestinal inflammation by influencing macrophage function and driving a switch from a proinflammatory to an anti-inflammatory phenotype. This phenotypic plasticity, accompanied by changes in cytokines, chemokines, and bioactive metabolites, contributes to the resolution of inflammation in the gut and restoration of epithelial barrier integrity. The review highlights the importance of selenium-dependent regulation of arachidonic acid metabolism and emphasizes the role of macrophages in supporting resolution in IBD.
Theoretical Article Review Article Irritable Bowel Syndrome SeleniumPresentation Slides
Pu-erh tea may prevent circadian rhythm disorders by promoting tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
Two French natural mineral waters (NMW1 and NMW2) show anti-inflammatory effects and can reduce intestinal inflammation in mice with induced colitis.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.