Nephropathy

Presentation Slides

Chinese Medicine Research Hub

Experimental Study

The herbal decoction Jian-Pi-Yi-Shen reduces symptoms of chronic kidney disease and anaemia by improving iron metabolism and inhibiting the JAK2-STAT3 signaling pathway.

2023 Journal of Ethnopharmacology Jian-Pi-Yi-Shen formula restores iron metabolism from dysregulation in anemic rats with adenine-induced nephropathy
Li C, Huang H, Wang R, Zhang C, Huang S, Wu J, Mo P, Yu H, Li S, Chen J

Chinese Medicine Research Hub

Systematic Review

Chinese medicine could effectively improve thyroid function and the clinical symptoms of patients with diabetic nephropathy.

2021 Annals of Palliative Medicine Meta-analysis-based systematic review of effect of traditional Chinese medicine intervention in treatment of diabetic nephropathy on thyroid function
Zhang X, Wu M, Zhou J, Zhou R, Luo Q, Yue R, Jin S.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Nephropathy" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Nephropathy" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Nephropathy" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Experimental Study published in 2023 in the journal Journal of Ethnopharmacology found that The herbal decoction Jian-Pi-Yi-Shen reduces symptoms of chronic kidney disease and anaemia by improving iron metabolism and inhibiting the JAK2-STAT3 signaling pathway. Methodology used included an analysis of network pharmacology, chemical profiling, and in vivo experiments on the effect of Jian-Pi-Yi-Shen (JPYS) on renal anemia and chronic kidney disease (CKD). The active compounds in JPYS were detected in in vivo experiment, and their potential targets were predicted by network pharmacology. An animal model of CKD-related anemia was developed using adenine-feeding for further analysis. The estimation of renal injury was conducted using blood tests, histopathological examinations, and fibrosis degree assessment while the levels of JAK2, STAT3 and iron metabolism-related factors were measured through various techniques. Discussion of the results reveals that 164 active ingredients, including prototypes and metabolites in JPYS, were discovered and 21 core targets were identified. Many of these core targets were associated with the JAK2-STAT3 signaling pathways. Experimental results demonstrated that JPYS treatment significantly improved hematological parameters and iron metabolism in CKD rats, decreased certain indicators of renal damage, and suppressed the expression of JAK2 and STAT3.

A Systematic Review published in 2021 in the journal Annals of Palliative Medicine found that Chinese medicine could effectively improve thyroid function and the clinical symptoms of patients with diabetic nephropathy. A meta-analysis conducted to evaluate the thyroid function of patients with DN found that it was impaired to varying degrees. Analysis of the clinical efficacy of TCM intervention in the treatment of DN showed that TCM could effectively improve the clinical symptoms of patients and improve the treatment effect. However, due to the small sample size, only the curative effect after the treatment was analyzed, and the long-term efficacy of TCM intervention in the treatment of DN remains unknown. Follow-up research of a higher quality involving larger samples, and multi-center RCT trials should be carried out to supplement the deficiencies of this research, and more accurately evaluate the clinical efficacy of TCM intervention in the treatment of DN.

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