Neurotrophic Factor
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Jujube fruit promotes the growth of nerve cells and boosts anti-oxidant enzyme production in brain cells.
Brain-Derived Neurotrophic Factor Jujube Nerve Growth Factor
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Antidepressant effects of the traditional Chinese herbal formula Xiao-Yao-San and its bioactive ingredients
2023 Jan Phytomedicine Wang YT, Wang XL, Wang ZZ, Lei L, Hu D, Zhang Y
Xiao-Yao-San (XYS) demonstrates effective antidepressant mechanisms correlated with the regulation of monoamine neurotransmitters, synaptic plasticity, hypothalamic–pituitary–adrenal axis, inflammation, brain-derived neurotrophic factor levels, brain-gut axis, and other pathways. While XYS plays a critical role in treating depression, further clinical and animal studies are needed to provide additional evidence and recommendations for its clinical application.
Review Article Xiao Yao San
Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
2022 Aug 10 Molecules Zakaria FH, Samhani I, Mustafa MZ, Shafin N
Review Article Depression Honey Anti-DepressantDepression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses.
Anti-Depressant Properties of Crocin Molecules in Saffron
2022 Mar 23 Molecules Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, et al.
Experimental Study Review Article Saffron DepressionSaffron and its bioactive molecules, notably crocins, have been found to be as effective as common antidepressants in treating depression disorders.
Neuroprotective Effect of Acupuncture against Single Prolonged Stress-Induced Memory Impairments and Inflammation in Rat Brain via Modulation of Brain-Derived Neurotrophic Factor Expression
2022 Feb 23 Evidence-Based Complementary and Alternative Medicine Lee B
Our results suggest that acupuncture is a potential treatment for PTSD-induced fear memory and impairments of both cognitive function and spatial memory in an SPS model. They also show that acupuncture inhibits neuroinflammation by reversing changes in the levels of proinflammatory cytokines and by regulating the levels of COX-2 and BDNF in the Hipp.
Animal Study Acupuncture NeuroprotectiveA Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection
2017 Jun 7 Evidence-Based Complementary and Alternative Medicine Chen J, Liu X, Li Z, et al.
Review Article Jujube Cognitive Function Neuroprotective Brain HealthJujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Depression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses.
2022 Molecules Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant Zakaria FH, Samhani I, Mustafa MZ, Shafin N
Review Article Anti-Depressant Depression Honey
This comprehensive review delves into the urgent need for safer and more effective depression treatments, considering the limitations of conventional drugs. The focus is on Stingless Bee Honey (SBH), recognized for its high antioxidant content, and its potential as an antidepressant is explored through the lenses of the monoamine, inflammatory, and neurotrophin hypotheses.
Stingless bee honey's potential as an antidepressant is examined in the context of its antioxidant richness, offering a new avenue for addressing depression beyond conventional drug approaches. The review highlights the importance of exploring alternative medicines, such as SBH, for safer and more efficacious depression treatments.
Saffron and its bioactive molecules, notably crocins, have been found to be as effective as common antidepressants in treating depression disorders.
2022 Molecules Anti-Depressant Properties of Crocin Molecules in Saffron Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, et al.
Experimental Study Depression Saffron
The methodology of the research centered on the incredible therapeutic properties of saffron, more specifically its bioactive molecules known as crocins. These molecules were singled out as they have shown a capacity to inhibit monoamine oxidase type A and B. The researchers also conducted experiments with saffron petal extracts, observing their impact on contractile response in electrical field stimulation. There were further investigations into saffron's ability to inhibit the reuptake of monoamines, display -methyl-d-aspartate antagonism, and enhance brain-derived neurotrophic factor signaling.
The discussion of the results highlighted the effectiveness of saffron and its crocins in treating depressive disorders. From several experimental studies, it became apparent that saffron and crocins might perform similarly to fluoxetine and imipramine, both widely accepted antidepressant drugs. As such, the paper suggests that these natural elements found in saffron could offer an alternative treatment method for depression. The limitations, however, as highlighted in the study, were issues surrounding stability and delivery of the herbal treatment.
Jujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning.
2017 Evidence-Based Complementary and Alternative Medicine A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection Chen J, Liu X, Li Z, et al.
Review Article Brain Health Cognitive Function Jujube
Jujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning. Flavonoid, cAMP, and jujuboside could be the potential bioactive ingredients to account for the aforesaid biological activities. These findings imply that jujube is a potential candidate for development of health supplements for prevention and/or treatment of neurological diseases.
Jujube fruit promotes the growth of nerve cells and boosts anti-oxidant enzyme production in brain cells.
2014 Phytotherapy Research A Chemically Standardized Extract of Ziziphus jujuba Fruit (Jujube) Stimulates Expressions of Neurotrophic Factors and Anti‐oxidant Enzymes in Cultured Astrocytes Chen J, Yan AL, Lam KYC, Lam CTW, Li N, Yao P, et al.
Experimental Study Brain-Derived Neurotrophic Factor Jujube Nerve Growth Factor
The methodology focused on the application of a water extract from the jujube fruit to cultured astrocytes (star-shaped glial cells in the brain and spinal cord) and observing any resulting changes over a 24-hour period. Researchers utilized a protein kinase A inhibitor, H89, to ascertain if it lessened the apparent jujube-induced expression of neurotrophic factors, assessed in a concentration-dependent manner.
In the discussion of results, it was established that the jujube extract effectively stimulated the expression of several key neurotrophic factors including nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. These are pivotal in neural survival, growth, and differentiation. Concurrently, the extract also enhanced the transcriptional expressions of various significant enzymes responsible for anti-oxidation in a comparable concentration-dependent manner, indicating that jujube not only contributes to neural growth but also fosters the astrocytes' resistance to oxidative stress.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Antidepressant effects of the traditional Chinese herbal formula Xiao-Yao-San and its bioactive ingredients
2023 Jan Phytomedicine Wang YT, Wang XL, Wang ZZ, Lei L, Hu D, Zhang Y
Xiao-Yao-San (XYS) demonstrates effective antidepressant mechanisms correlated with the regulation of monoamine neurotransmitters, synaptic plasticity, hypothalamic–pituitary–adrenal axis, inflammation, brain-derived neurotrophic factor levels, brain-gut axis, and other pathways. While XYS plays a critical role in treating depression, further clinical and animal studies are needed to provide additional evidence and recommendations for its clinical application.
Review Article Xiao Yao SanPathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
2022 Aug 10 Molecules Zakaria FH, Samhani I, Mustafa MZ, Shafin N
Review Article Depression Honey Anti-DepressantDepression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses.
Anti-Depressant Properties of Crocin Molecules in Saffron
2022 Mar 23 Molecules Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, et al.
Experimental Study Review Article Saffron DepressionSaffron and its bioactive molecules, notably crocins, have been found to be as effective as common antidepressants in treating depression disorders.
A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection
2017 Jun 7 Evidence-Based Complementary and Alternative Medicine Chen J, Liu X, Li Z, et al.
Review Article Jujube Cognitive Function Neuroprotective Brain HealthJujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning.
Presentation Slides
Depression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses.
Saffron and its bioactive molecules, notably crocins, have been found to be as effective as common antidepressants in treating depression disorders.
Jujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning.
Jujube fruit promotes the growth of nerve cells and boosts anti-oxidant enzyme production in brain cells.
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