Ovarian Insufficiency
Also known as: Decreased Ovarian Reserve, Premature Ovarian Failure, Premature Ovarian Insufficiency
Recent Insights
The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
Ovarian Insufficiency Premature ovarian failure (POF) You Gui Wan
The present study indicated that acupuncture had an advantage over hormone replacement therapy in reducing serum FSH level and increasing serum E2 level in women with premature ovarian insufficiency.
HRT Ovarian Function Ovarian Insufficiency
In a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
Ovarian Insufficiency
Acupuncture may impact Luteinized Unruptured Follicle Syndrome (LUFS) by lowering FSH, increasing E2, and resuming menstruation.
Ovarian Insufficiency
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Propolis protects ovarian follicular reserve and maintains the ovary against polycystic ovary syndrome (PCOS) by attenuating degeneration of zona pellucida and fibrous tissue
2022 Dec Biochemical and Biophysical Research Communications Sapmaz T, Sevgin K, Topkaraoglu S, Tekayev M, Gumuskaya F, Efendic F, et al.
In conclusion, a lower dose of propolis (50 mg/kg) exerts more therapeutic effects than a higher dose (150 mg/kg) in rats with PCOS, while the excessive consumption of propolis has no further therapeutic effect.
Network Pharmacology Animal Study Ovarian Insufficiency PCOS PropolisA Network Pharmacology Study on the Similarities and Differences in the Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of Premature Ovarian Failure
2022 Oct 18 Combinatorial Chemistry & High Throughput Screening Shanshan Mei, Chaoqin Yu, Jie Ding, Wen Cheng
Network Pharmacology Premature ovarian failure (POF) Zuo Gui Wan You Gui Wan Ovarian InsufficiencyThe Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
Ningxin Tongyu Zishen Tang in Treatment of Premature Ovarian Insufficiency: A Retrospective Control Study
2022 Aug Clinical Complementary Medicine and Pharmacology Yan X, Zhang Z, Ma J, Zhang Y
The study found that Ningxin Tongyu Zishen Tang (NTZT) could restore menstruation and improve the levels of sex hormone in patients with premature ovarian insufficiency (POI). It was also found that NTZT could eliminate the feelings of vexation, insomnia and dreamfulness, as well as tidal fever and sweating, aching pain of loins, and vaginal dryness significantly.
Ovarian Insufficiency Ningxin Tongyu Zishen Tang (NTZT)Current Research on Complementary and Alternative Medicine in the Treatment of Premature Ovarian Failure: An Update Review
2022 Jun 23 Evidence-Based Complementary and Alternative Medicine Li Y, Yan MY, Chen QC, Xie YY, Li CY, Han FJ
In recent years, clinical and scientific researchers have paid more attention to POF and its associated symptoms such as amenorrhea and infertility. As the research has progressed, more and more CAM therapies have become widely accepted and well used, including herbal medicine, acupuncture, psychology, exercise, vitamins, massage, diet, etc. These therapies can significantly improve the patient's symptoms and hormone levels and can be used in combination with other treatments to enhance their efficacy.
Review Article Ovarian Insufficiency Complementary MedicineComplementary and Alternative Medicine for Premature Ovarian Insufficiency: A Review of Utilization and Mechanisms
2022 Apr 01 Evidence-Based Complementary and Alternative Medicine Yang Fu, Dan-Ni Ding, Ying Shen, Li-Yan Jia, Meng-Yu Yan, Wei Wei, et al.
Review ArticleResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
2022 Combinatorial Chemistry & High Throughput Screening A Network Pharmacology Study on the Similarities and Differences in the Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of Premature Ovarian Failure Shanshan Mei, Chaoqin Yu, Jie Ding, Wen Cheng
Network Pharmacology Premature ovarian failure (POF) You Gui Wan Zuo Gui Wan
This study used a public database to identify the active ingredients and potential targets of the Zuo Gui Wan and You Gui Wan compounds. These were analyzed in relation to premature ovarian failure (POF) related genes obtained from OMIM and GeneCards. A protein-protein interaction network was established using STRING, and a drug-active ingredient-target gene network was constructed. The study thus identified similarities and differences in potential targets, active ingredients, and enriched pathways between the two compounds.
Analyzing the drug-target-pathway network revealed that both compounds contain multiple common active ingredients, as well as unique components, and share several targets in the treatment of POF, showing similar core mechanisms of action. However, each compound also targets some unique pathways, which indicates their differential approaches to POF treatment.
In a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
2020 Complementary Therapies in Medicine Acupoint stimulation and Chinese herbal medicines for the treatment of premature ovarian insufficiency: A systematic review and meta-analysis Li Y, Xia G, Tan Y, Shuai J
Systematic Review
In a meta-analysis involving 14 trials with 1030 women experiencing Premature Ovarian Insufficiency (POI), acupoint stimulation and Chinese Herbal Medicine (CHM) were found to offer benefits in normalizing menstrual cycles and improving perimenopausal symptoms, compared to Hormone Replacement Therapy (HRT). These treatments also effectively lowered follicle stimulating hormone levels and increased estradiol levels when compared to HRT. However, there were no significant differences in luteinizing hormone levels or adverse effects between the groups. The conclusion of the study is that acupoint stimulation and CHM can be considered complementary therapies for alleviating menstrual disorders, perimenopausal symptoms, and serum sex hormone levels in POI females.
The present study indicated that acupuncture had an advantage over hormone replacement therapy in reducing serum FSH level and increasing serum E2 level in women with premature ovarian insufficiency.
2020 Journal of Acupuncture and Tuina Science Acupuncture for premature ovarian insufficiency: a systematic review and meta-analysis Yin, Yq., Xu, Hf., Fang, Yg. et al.
Systematic Review HRT Ovarian Function Women's Health
Eight eligible RCTs with a total of 496 POI patients were included in the meta-analysis. The pooled results showed that there was a significant reduction in the basal serum FSH level and a remarkable elevation in the basal E2 level in the acupuncture group when compared with the control. Subgroup analysis showed that compared with HRT, a significant decrease in the FSH level was observed in both acupuncture alone and acupuncture plus HRT, while a remarkable elevation of E2 was only found in acupuncture plus HRT. There was no significant difference in the LH level between acupuncture and HRT, only one trial reported AMH, and no significant difference was found between acupuncture and HRT.
Acupuncture may impact Luteinized Unruptured Follicle Syndrome (LUFS) by lowering FSH, increasing E2, and resuming menstruation.
2015 Evidence-Based Complementary and Alternative Medicine Effectiveness of Acupuncture for Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis Jo J, Lee YJ, Lee H
Systematic Review
This systematic review and meta-analysis assessed the potential of acupuncture for treating Luteinized Unruptured Follicle Syndrome (LUFS) through Randomized Controlled Trials (RCTs). Analyzing 8 studies involving 620 participants, the review found that acupuncture, whether alone or combined with drugs, could lower follicle-stimulating hormone (FSH) levels and increase the likelihood of menstruation resumption. Serum estradiol (E2) levels significantly increased with acupuncture, while luteinizing hormone (LH) levels showed no clear changes. Limited data on adverse events (AEs) suggested acupuncture's relative safety. However, due to small sample sizes, risk of bias, and varying study methodologies, the overall evidence quality was rated as "low" or "very low." This suggests a potential benefit of acupuncture for LUFS, but further high-quality studies are necessary to establish its effectiveness and safety definitively.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Current Research on Complementary and Alternative Medicine in the Treatment of Premature Ovarian Failure: An Update Review
2022 Jun 23 Evidence-Based Complementary and Alternative Medicine Li Y, Yan MY, Chen QC, Xie YY, Li CY, Han FJ
In recent years, clinical and scientific researchers have paid more attention to POF and its associated symptoms such as amenorrhea and infertility. As the research has progressed, more and more CAM therapies have become widely accepted and well used, including herbal medicine, acupuncture, psychology, exercise, vitamins, massage, diet, etc. These therapies can significantly improve the patient's symptoms and hormone levels and can be used in combination with other treatments to enhance their efficacy.
Review Article Ovarian Insufficiency Complementary MedicineComplementary and Alternative Medicine for Premature Ovarian Insufficiency: A Review of Utilization and Mechanisms
2022 Apr 01 Evidence-Based Complementary and Alternative Medicine Yang Fu, Dan-Ni Ding, Ying Shen, Li-Yan Jia, Meng-Yu Yan, Wei Wei, et al.
Review ArticleAcupoint stimulation and Chinese herbal medicines for the treatment of premature ovarian insufficiency: A systematic review and meta-analysis
2020 Nov Complementary Therapies in Medicine Li Y, Xia G, Tan Y, Shuai J
Systematic Review Meta-Analysis Ovarian InsufficiencyIn a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
Acupuncture for premature ovarian insufficiency: a systematic review and meta-analysis
2020 Feb 24 Journal of Acupuncture and Tuina Science Yin, Yq., Xu, Hf., Fang, Yg. et al.
Systematic Review Meta-Analysis Ovarian Function Women's Health Ovarian Insufficiency HRTThe present study indicated that acupuncture had an advantage over hormone replacement therapy in reducing serum FSH level and increasing serum E2 level in women with premature ovarian insufficiency.
Effectiveness of Acupuncture for Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis
2015 May 18 Evidence-Based Complementary and Alternative Medicine Jo J, Lee YJ, Lee H
Systematic Review Meta-Analysis Ovarian InsufficiencyAcupuncture may impact Luteinized Unruptured Follicle Syndrome (LUFS) by lowering FSH, increasing E2, and resuming menstruation.
Presentation Slides
The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.
In a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
The present study indicated that acupuncture had an advantage over hormone replacement therapy in reducing serum FSH level and increasing serum E2 level in women with premature ovarian insufficiency.
Acupuncture may impact Luteinized Unruptured Follicle Syndrome (LUFS) by lowering FSH, increasing E2, and resuming menstruation.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.