Prunes
Recent Insights
Prunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women.
Bone Health Bone Loss Plum
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study
2022 Oct The American Journal of Clinical Nutrition De Souza MJ, Strock NCA, Williams NI, Lee H, Koltun KJ, Rogers C, et al.
Randomised Controlled Trial Bone Mineral Density PlumA daily intake of 50 grams of prunes can maintain hip bone density in postmenopausal women, potentially reducing hip fracture risks.
The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women
2022 Sep Advances in Nutrition Damani JJ, De Souza MJ, VanEvery HL, Strock NCA, Rogers CJ
Systematic Review Review Article Prunes Bone Loss Bone Health PlumPrunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women.
Fruits and their impact on the gut microbiota, gut motility and constipation
2021 Jan Food & Function Katsirma Z, Dimidi E, Rodriguez-Mateos A, Whelan K
Prunes, raisins and apple fiber isolate have been shown to increase fecal weight in humans, whilst kiwifruit to increase small bowel and fecal water content. Apple fiber isolate, kiwifruit, fig paste, and orange extract have been shown to reduce gut transit time, while prunes have not. There is limited evidence on which fruit components play a predominant role in regulating gut motility and constipation, or whether a synergy of multiple components is responsible for such effects.
Review Article Prunes Raisins
Dried Plums, Prunes and Bone Health: A Comprehensive Review
2017 Apr 19 Nutrients Wallace T
Review Article Osteoporosis Bone Health PlumDried plums, or prunes, have potential to exert beneficial effects on bone health and may help in combating osteoporosis in postmenopausal women, if consumed as part of their recommended fruit intake.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
A daily intake of 50 grams of prunes can maintain hip bone density in postmenopausal women, potentially reducing hip fracture risks.
2022 The American Journal of Clinical Nutrition Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study De Souza MJ, Strock NCA, Williams NI, Lee H, Koltun KJ, Rogers C, et al.
Randomised Controlled Trial Bone Mineral Density Plum
This research was conducted through a single-center, parallel-arm, randomized controlled trial over the course of a year. Postmenopausal women were randomly assigned into three groups - control, 50 grams of prunes, and 100 grams of prunes - and their bone mineral density (BMD) was assessed every 6 months. Secondary measurements included an observation of changes in bone biomarkers. Compliance and retention of participants were high particularly at the 50-gram dosage.
In assessing the effects of prunes on bone health, the findings showed a distinct interaction between the amount of prune intake and bone mineral density in the hip region. Specifically, it indicated that consumption of 50 grams of prunes daily led to a preservation of hip BMD after 6 months, an effect which was still apparent after a year. Despite a higher dropout rate and less impact on BMD, the 100-gram prune group, when combined with the 50-gram group, presented stability in the FRAX score, which measures the risk of hip fractures.
Prunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women.
2022 Advances in Nutrition The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women Damani JJ, De Souza MJ, VanEvery HL, Strock NCA, Rogers CJ
Systematic Review Bone Health Bone Loss Plum
Using sixteen preclinical trials with in vivo rodent models of osteopenia or osteoporosis, researchers investigated the effect of dietary supplementation with prunes. The research shows prunes' osteoprotective capabilities, preventing, reversing bone loss, and exerting anti-inflammatory and antioxidant effects. The prunes or their polyphenol extracts showed properties that decreased malondialdehyde and NO secretion and increased antioxidant enzyme expression. Two clinical trials further investigated prune consumption (50-100 g/d for 6-12 months) on bone health in postmenopausal women.
The results of the studies revealed the promising outcome of improved bone mineral density and bone biomarker due to the consumption of dried plums. However, the effect of prunes on oxidative stress and inflammatory mediators remains less understood. The study hence emphasizes the need to investigate prunes' role in modulating the inflammatory and immune pathways related to bone health.
Dried plums, or prunes, have potential to exert beneficial effects on bone health and may help in combating osteoporosis in postmenopausal women, if consumed as part of their recommended fruit intake.
2017 Nutrients Dried Plums, Prunes and Bone Health: A Comprehensive Review Wallace T
Review Article Bone Health Osteoporosis Plum
The research process involved a comprehensive review of scientific literature available in the PubMed database up until January 24, 2017. This literature included cell studies, animal studies, population and clinical studies that examined effects of dried plums or their extracts on markers of bone health. In total, 24 research papers were reviewed and their findings are summarized.
Discussing the results, animal, cell, and clinical studies suggest that dried plums or their extracts positively impact bone formation and limit bone breakdown. This is likely due to the influence of dried plums on cell signaling pathways that dictate osteoblast (bone-building cells) and osteoclast (bone-destroying cells) differentiation. Clinical studies also indicate that consumption of dried plums could have beneficial effects on bone mineral density, particularly in postmenopausal women. There were no adverse effects reported in these studies, further suggesting that they could safely be included in regular dietary routines.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women
2022 Sep Advances in Nutrition Damani JJ, De Souza MJ, VanEvery HL, Strock NCA, Rogers CJ
Systematic Review Review Article Prunes Bone Loss Bone Health PlumPrunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women.
Fruits and their impact on the gut microbiota, gut motility and constipation
2021 Jan Food & Function Katsirma Z, Dimidi E, Rodriguez-Mateos A, Whelan K
Prunes, raisins and apple fiber isolate have been shown to increase fecal weight in humans, whilst kiwifruit to increase small bowel and fecal water content. Apple fiber isolate, kiwifruit, fig paste, and orange extract have been shown to reduce gut transit time, while prunes have not. There is limited evidence on which fruit components play a predominant role in regulating gut motility and constipation, or whether a synergy of multiple components is responsible for such effects.
Review Article Prunes RaisinsDried Plums, Prunes and Bone Health: A Comprehensive Review
2017 Apr 19 Nutrients Wallace T
Review Article Osteoporosis Bone Health PlumDried plums, or prunes, have potential to exert beneficial effects on bone health and may help in combating osteoporosis in postmenopausal women, if consumed as part of their recommended fruit intake.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Presentation Slides
A daily intake of 50 grams of prunes can maintain hip bone density in postmenopausal women, potentially reducing hip fracture risks.
Prunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women.
Dried plums, or prunes, have potential to exert beneficial effects on bone health and may help in combating osteoporosis in postmenopausal women, if consumed as part of their recommended fruit intake.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.