Zuo Gui Wan

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Chinese Medicine Research Hub

Network Pharmacology

The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways.

2022 Combinatorial Chemistry & High Throughput Screening A Network Pharmacology Study on the Similarities and Differences in the Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of Premature Ovarian Failure
Shanshan Mei, Chaoqin Yu, Jie Ding, Wen Cheng

Chinese Medicine Research Hub

Systematic Review

Zuo Gui Wan combined with anti-osteoporosis drugs may have beneficial effects on osteoporosis with respect to bone mineral density and bone metabolism markers.

2020 Phytotherapy Research An evaluation of the effects and safety of Zuogui pill for treating osteoporosis: Current evidence for an ancient Chinese herbal formula
Li J, Sun K, Qi B, Feng G, Wang W, Sun Q, Zheng C, Wei X, Jia Y

Chinese Medicine Research Hub

Review Article

Traditional Chinese medicine, especially Zuo Gui Wan, red raspberry leaves, and Orthosiphon stamineus, seems to control gestational diabetes effectively without reported toxicity.

2019 Journal of Diabetes Research Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus
Xu YXZ, Xi S, Qian X

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Zuo Gui Wan" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Zuo Gui Wan" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Zuo Gui Wan" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Network Pharmacology published in 2022 in the journal Combinatorial Chemistry & High Throughput Screening found that The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways. This study used a public database to identify the active ingredients and potential targets of the Zuo Gui Wan and You Gui Wan compounds. These were analyzed in relation to premature ovarian failure (POF) related genes obtained from OMIM and GeneCards. A protein-protein interaction network was established using STRING, and a drug-active ingredient-target gene network was constructed. The study thus identified similarities and differences in potential targets, active ingredients, and enriched pathways between the two compounds. Analyzing the drug-target-pathway network revealed that both compounds contain multiple common active ingredients, as well as unique components, and share several targets in the treatment of POF, showing similar core mechanisms of action. However, each compound also targets some unique pathways, which indicates their differential approaches to POF treatment.

A Systematic Review published in 2020 in the journal Phytotherapy Research found that Zuo Gui Wan combined with anti-osteoporosis drugs may have beneficial effects on osteoporosis with respect to bone mineral density and bone metabolism markers. Our pooled results show that ZGP combined with anti-osteoporosis drugs may have beneficial effects on osteoporosis with respect to BMD and bone metabolism markers. There were no ADRs when using ZGP alone, but ADRs of ZGP combined with anti-osteoporosis drugs included gastrointestinal discomfort (nausea, diarrhoea), dizziness, and fatigue. However, a definite conclusion regarding other indicators cannot be drawn from the existing information. The results of this review demonstrate that ZGP is a potential candidate for osteoporosis treatment, although the quality of evidence remains weak.

A Review Article published in 2019 in the journal Journal of Diabetes Research found that Traditional Chinese medicine, especially Zuo Gui Wan, red raspberry leaves, and Orthosiphon stamineus, seems to control gestational diabetes effectively without reported toxicity. The study initiated a systematic search across PubMed, Web of Science, and Embase databases to pinpoint research discussing the impact of traditional Chinese medicine on pregnancy. The results were then further narrowed down to focus on any correlation with all forms of diabetes mellitus. The primary thread that emerged was the beneficial effect of three main herbal remedies: Zuo Gui Wan, red raspberry leaves, and Orthosiphon stamineus. Based off of the results from this search, a focal review of these herbal elements and their associations with type 2 diabetes mellitus was undertaken. Across the board, these remedies demonstrated positive effects on metabolic health, especially among women dealing with gestational diabetes. No experimental models reported any toxicity or harmful side effects associated with these herbal treatments. The report calls out that current studies on both conventional and alternative interventions for gestational diabetes are immensely lacking, emphasizing the need for a standardized protocol to evaluate the efficacy of these herbal medicines.

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