Insights & Discussion
Xiao Yao San, alone or combined with anxiolytics, assists in better improvement and safety in treating anxiety disorders compared to anxiolytics alone.
The methodology involved a systematic search on PubMed, Cochrane Library, EMBASE, Web of Science, and several Chinese databases for all randomized control trials (RCTs) that have evaluated the use of XYS for treating anxiety disorders until November 2021. The studies were independently screened, and data were extracted by two investigators who also assessed the risk of bias in the selected trials using RevMan5.3 software.
The meta-analysis result shows that the use of XYS, either on its own or together with anxiolytics, showed better improvements in anxiety-related symptoms and fewer adverse drug reactions compared to treatment with anxiolytics only. This suggests that XYS, whether used alone or in conjunction with anxiolytic agents, appears to offer a more effective and safer treatment option for anxiety disorders.
Discover Related Insights
A combination of Walnut Peptide and Casein Peptide substantially alleviates anxiety disorder symptoms and enhances memory by improving neurotransmitter function in mice.
2023 Frontiers in Nutrition Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices Li Q, Jia X, Zhong Q, Zhong Z, Wang Y, Tang C, et al.
Anxiety Memory Walnut
The study investigated the effects of the combination of Walnut Peptide (WP) and Casein Peptide (CP) in mice exhibiting elevated anxiety levels by giving them these peptides through oral gavage administration. The researchers designed assessments to carefully examine changes in the subjects' anxiety and memory-related behaviors following this treatment. Besides monitoring behavior, they also scrutinized the levels of several neurotransmitters, such as Serotonin, gamma-aminobutyric acid, dopamine, and acetylcholine, to identify the biological mechanisms underlying the observed effects.
The mice treated with the WP + CP combination demonstrated significant improvement in behavioral tests related to anxiety and memory. The analysis also showed that the peptide combination resulted in restoring neurotransmitter dysfunction observed while examining neurotransmitter levels. The peptides had the additional effect of increasing the expression of brain-derived neurotrophic factor mRNA, suggesting a protective role against the neurological effects of anxiety. The research revealed strong correlations between the improvement in behavioral indicators, increased brain-derived neurotrophic factor, and neurotransmitter levels. The study concluded that the WP+CP combination might serve as an effective alternative therapy for anxiety disorders, implying potential usefulness as dietary supplements or inclusions in common foods.
Chinese herbal medicine was effective in treating coronary heart disease patients with anxiety or depression, particularly in improving angina pectoris, and its active compounds could act on the pathological targets of CHD, anxiety, and depression.
2022 Frontiers in Pharmacology Evidence and Characteristics of Traditional Chinese Medicine for Coronary Heart Disease Patients With Anxiety or Depression: A Meta-Analysis and Systematic Review Wang B, Teng Y, Li Y, Lai S, Wu Y, Chen S, et al.
Systematic Review Angina Anxiety Cardiovascular Disease
The meta-analysis of 32 studies found that Chinese herbal medicine (CHM) was more effective in treating anxiety and depression in patients with coronary heart disease (CHD) compared to control groups, and the efficacy of CHM was similar to Western medicine. Additionally, CHM was shown to improve angina stability in CHD patients with anxiety or depression better than control and Western medicine groups. The study identified the main underlying mechanisms to involve anti-damage/apoptosis, anti-inflammation, antioxidative stress, and maintaining neurotransmitter homeostasis, with certain herbal compounds being most related to CHD, anxiety, and depression.
High prevalence of insomnia, anxiety, and depression among perimenopausal women, emphasizing the importance of exploring acupuncture as a potential green therapy for effectively addressing these interconnected issues.
2022 Medicine Can acupuncture improve sleep quality and anxiety among women during perimenopause? Ping Y, Liang C, Fan X, Zhang L, Ying D, Wang Z
Systematic Review Anxiety Insomnia Menopause
This passage discusses the prevalence of insomnia among perimenopausal women, its association with anxiety and depression, and the potential of acupuncture as a green therapy for treating these issues. The passage outlines the objectives and methods of a systematic review aiming to evaluate the efficacy of acupuncture in improving sleep quality and alleviating anxiety and depression in perimenopausal women, highlighting the need for safer alternatives to conventional medications and the significance of such a study.
The Gui Zhi-Shao Yao herb pair in traditional Chinese medicine potentially treats chronic pain, anxiety, and depression through interactions with nine key targets.
2022 Annals of Medicine A network pharmacology approach to predict potential targets and mechanisms of “Ramulus Cinnamomi (cassiae) – Paeonia lactiflora” herb pair in the treatment of chronic pain with comorbid anxiety and depression Pan HT, Xi ZQ, Wei XQ, Wang K
Network Pharmacology Anxiety Chronic Pain Depression
The methodology in this research utilised network pharmacology to explore the active components of the "Gui Zhi-Shao Yao" herb pair and their possible targets. Initially, 15 active compounds were identified through a series of analysis which revealed about 130 potential targets. By considering the intersections between the targets of the "Gui Zhi-Shao Yao" herb pair and chronic pain, anxiety disorder, and mental depression, nine vital targets were identified and listed in order of importance.
The results discussion revealed that the "Gui Zhi-Shao Yao" herb pairing acted on the nine identified key targets to alleviate chronic pain, anxiety, and depression. Gene ontology and pathway analysis demonstrated that there were 11 primary pathways, including AGE-RAGE signalling pathway, IL-17 signalling pathway, and TNF signalling pathway. These pathways appear to be actively involved in the pathological processes, providing a holistic understanding of how the "Gui Zhi-Shao Yao" herb pair functions therapeutically.
Chinese herbal medicine shows promising and safe outcomes in relieving functional dyspepsia symptoms and associated psychological disorders.
2022 Frontiers in Neuroscience Chinese Herbal Medicine for Functional Dyspepsia With Psychological Disorders: A Systematic Review and Meta-Analysis Luo X, Wang L, Fang S, Qing X, Jiang T, Yang Y, et al.
Systematic Review Anxiety Chinese Herbal Medicine Depression
The methodology for this research involved a comprehensive search across various libraries and databases, such as PubMed, Embase, Cochrane Library, Web of Science, and various Chinese data sources, seeking randomized controlled trials where functional dyspepsia was treated with Chinese herbal medicine. The aim was to assess the efficacy and safety of this type of treatment for functional dyspepsia. Two researchers independently conducted each stage of the process, from searching the sources, screening the documents, extracting data, and assessing risk biases within the included studies. They used RevMan 5.4 software to do a meta-analysis of the selected research materials.
The discussion of their findings showed that treatment with Chinese herbal medicine significantly alleviated the symptoms of functional dyspepsia, compared to both a placebo group and a group treated with traditional prokinetic agents and flupentixol melitracen. Patients treated with Chinese herbal medicine reported higher total effective rates and lower total symptom scores, along with smaller depression and anxiety scores. The symptoms of functional dyspepsia, in this case, were improved more successfully with Chinese herbal medicine than with other treatment types, without any significant adverse reactions.
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