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Pomegranate juice extract may reduce the damage to the endometrium in Polycystic ovary syndrome through its antioxidant, anti-inflammatory, anti-fibrotic, and anti-proliferative effects.
2022 Morphologie Role of pomegranate extract in restoring endometrial androgen receptor expression, proliferation, and pinopodes in a rat model of polycystic ovary syndrome Ibrahim MAA, Sadek MT, Sharaf Eldin HEM
Experimental Study Endometrium PCOS Pomegranate
To test the possible benefits of pomegranate juice extract (PJE) on endometrial injury in Polycystic ovary syndrome (PCOS), forty adult albino rats were divided into four groups, control, PJE-treated, letrozole-treated (PCOS), and PJE & PCOS groups. The respective treatments were administered for a duration of three weeks. Serum and tissue samples were assayed for Follicle-stimulating hormone, Luteinizing hormone, testosterone, estradiol, and malondialdehyde. Uterine samples were also tested using a range of histological staining techniques and a scanning electron microscope.
In the rat model of PCOS, significant increases in certain biochemical indicators in serum samples were observed while uterine sections showed numerous alterations to the endometrium, signs of inflammation and an increase in the endometrial collagen fiber content. Additionally, there was increased expression of certain immunohistochemical staining markers and a decrease in the mean number of pinopodes observed through scanning electron microscopy. However, these various potentially harmful biochemical, histological and immunohistochemical alterations were efficiently reduced with the administration of PJE. This points towards the potential benefits of PJE in addressing and potentially reducing endometrial injury associated with PCOS.
Acupuncture shows promise in improving endometrial receptivity and fertility outcomes in infertile women, but further high-quality research is needed to establish its effectiveness definitively.
2019 BMC Complementary Medicine and Therapies Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis Zhong, Y., Zeng, F., Liu, W. et al.
Systematic Review Endometrium Female Fertility
This systematic review aimed to assess the effectiveness of acupuncture in improving endometrial receptivity (ER) based on randomized controlled trials (RCTs). The review included RCTs of infertile women with low ER and excluded other causes of infertility or non-RCTs. The researchers conducted an extensive search through various databases up to August 2018 without language restrictions. After analyzing the collected data, they found evidence indicating that acupuncture may enhance pregnancy rate, embryo transfer rate, trilinear endometrium, endometrial thickness, and decrease resistive index, pulse index, and peak systolic velocity/end-diastolic blood velocity when compared with medication, sham acupuncture, or physiotherapy. However, the overall level of evidence was mostly very low or low. Despite the statistically significant results, the authors emphasize the need for more large-scale, long-term RCTs with robust methodologies to further validate the efficacy and safety of acupuncture for women with low ER