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Acupuncture may have a positive impact on clinical pregnancy rate and live birth rate in women undergoing in vitro fertilization (IVF), although the results are limited by the heterogeneity of the current evidence.
2023 Chinese Journal of Integrative Medicine Pregnancy Benefit of Acupuncture on in vitro Fertilization: A Systematic Review and Meta-Analysis Zhang H, Zhang C, Ma P, Sun C, Sun C, Liu X, et al.
Systematic Review IVF
This study aimed to assess the efficacy of acupuncture on embryo transfer in women undergoing in vitro fertilization (IVF). A total of 49 randomized controlled trials (RCTs) involving 9422 women were analyzed. The results indicated that acupuncture had a significant positive impact on the clinical pregnancy rate (CPR) and live birth rate (LBR) compared to the control groups (odds ratio [OR]=1.65 for CPR, 1.34 for LBR). Subgroup analyses showed that traditional acupuncture was more beneficial for women aged < 35 years, those receiving ≥ 3 sessions, and those with lower baseline CPR rates in the control group. However, significant heterogeneity was observed among the studies. In conclusion, while there were some benefits of acupuncture in improving CPR and LBR in IVF, the results should be interpreted with caution due to the variability in the current evidence.
Fermented soy milk significantly improves lipid profiles and fertility in a model of premenopausal mice, due to increased bioavailability and action of beneficial compounds.
2023 Food Research International Effect of fermented soy beverage in aged female mice model Ruiz de la Bastida A, Langa S, Peirotén , Fernández-Gonzalez R, Sánchez-Jiménez A, Maroto M, et al.
Animal Study Menopause Ovarian Function Soy Milk
In this study, non-fermented soy beverage (SB) and soy beverage fermented with Bifidobacterium pseudocatenulatum INIA P815 (FSB) were tested on both cyclic and acyclic C57BL/6J aged female mice which mimic premenopause and menopause conditions respectively. Over a period of 36 days, the beverages were given to the mice and the variables measured included body weight, lipid and inflammatory profile and fertility. In addition, hepatic gene expressions were examined and the faecal microbiota composition was assessed to further understand the effects of the two beverages.
In the results, FSB displayed a higher concentration of the aglycones daidzein and genistein as well as increased antioxidant activity due to the fermentation process. The cyclic mice that were given FSB experienced a significant rise in the number of oocytes and zygotes retrieved. It was also noticed that the triglycerides were lower in the groups that were given FSB compared to the SB groups. However, it was found that neither of the treatments significantly influenced the inflammatory profile or caused a major shift in intestinal microbiota or hepatic gene expressions in either of the groups. Still, it was observed that FSB had more health benefits than SB with regards to the lipid profile and fertility in the cyclic mice, likely due to the increased bioavailability and bioactivity of compounds due to fermentation.
The date palm enhances both male and female fertility parameters through its nutritional attributes and antioxidant functionality.
2021 Metabolites Therapeutic Potential of Date Palm against Human Infertility: A Review Shehzad M, Rasheed H, Naqvi SA, Al-Khayri JM, Lorenzo JM, Alaghbari MA, et al.
Review Article Date Fruit Female Fertility Ovarian Function
The research conducted a thorough review of the role of date palm in treating infertility. The health benefits of date palm and its varied components were explored, with a focus on their effects on reproductive parameters in both sexes. The comprehensive review shed light on how the substantial nutrients and antioxidant features of date palm can be beneficial for people dealing with infertility.
In men, the study found direct links between consumption of date palm and improved hormonal levels alongside notable enhancements in seminal vesicle parameters and sperm quality. For women, this natural remedy showed a positive impact on the process of oogenesis, hormone regulation, and improving pregnancy outcomes. The focus was on the potential of date fruit as a natural enhancer of fertility, downplaying the role of any synthetic or invasive medical interventions. The study thus testifies to the innovative use of a widely available natural resource in addressing a pressing health issue.
The present study indicated that acupuncture had an advantage over hormone replacement therapy in reducing serum FSH level and increasing serum E2 level in women with premature ovarian insufficiency.
2020 Journal of Acupuncture and Tuina Science Acupuncture for premature ovarian insufficiency: a systematic review and meta-analysis Yin, Yq., Xu, Hf., Fang, Yg. et al.
Systematic Review HRT Ovarian Function Ovarian Insufficiency
Eight eligible RCTs with a total of 496 POI patients were included in the meta-analysis. The pooled results showed that there was a significant reduction in the basal serum FSH level and a remarkable elevation in the basal E2 level in the acupuncture group when compared with the control. Subgroup analysis showed that compared with HRT, a significant decrease in the FSH level was observed in both acupuncture alone and acupuncture plus HRT, while a remarkable elevation of E2 was only found in acupuncture plus HRT. There was no significant difference in the LH level between acupuncture and HRT, only one trial reported AMH, and no significant difference was found between acupuncture and HRT.
Acupuncture enhances Luteinized Unruptured Follicle Syndrome (LUFS) ovulation, hormone levels, artery characteristics.
2020 Complementary Therapies in Medicine Effects of acupuncture on Luteinized Unruptured Follicle Syndrome: A meta-analysis of randomized controlled trials Xiaojuan Liu, Wenying Shi, Zhifeng Liu, Shuqing Shi, Chao Ke, Peiming Zhang, et al.
Systematic Review Ovarian Function Unruptured Follicle Syndrome
This meta-analysis aimed to assess the overall effectiveness and safety of acupuncture for treating Luteinized Unruptured Follicle Syndrome (LUFS) using Randomized Controlled Trials (RCTs). Ten studies with 715 participants were analyzed. Acupuncture, whether used alone or alongside other treatments, significantly improved ovulation rates, as confirmed by Trial Sequential Analysis. However, evidence regarding acupuncture's impact on pregnancy rates was insufficient. The studies also showed improvements in hormone levels and ovarian artery characteristics. The level of evidence for most outcomes was rated as "low" or "very low," emphasizing the need for cautious interpretation. The conclusion suggests that acupuncture, either alone or in combination with drugs, is effective in improving ovulation in LUFS cases. However, due to limited concurrent evidence, further high-quality studies are required to strengthen these findings.
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