Insights & Discussion
Consumption of sardines can effectively prevent type 2 diabetes mellitus and hypertension, particularly in senior citizens, due to their high omega 3, EPA, and DHA content.
For the methodology, the researchers carried out a literature study to delve into the research topic. They exclusively used already available research and data for their study rather than new, hands-on investigations. They explored extensively into the health benefits and properties of sardines and how it contributes to preventing type 2 diabetes and hypertension.
In their discussion of the results, it was determined that sardines have multiple beneficial properties. They discovered that sardines have anti-inflammatory and antioxidant roles, they enhance membrane fluidity and increase insulin receptors and action. Furthermore, sardines also possess hypoglycemic and hypotensive qualities. The multitude of these properties thus shows the capability of sardines to effectively prevent and lower hypertension and type 2 diabetes, especially among senior citizens.
Sardines are highly proven to be able to effectively prevent type 2 diabetes, prevent hypertension, and lower blood pressure, especially for senior citizens.
Sardines contain anti-inflammatory, and antioxidant roles, boost cell membrane fluidity, boost the number of insulin receptors and insulin action, and also contain hypotensive and hypoglycemic effects.
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Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases.
2023 Frontiers in Nutrition Eating more sardines instead of fish oil supplementation: Beyond omega-3 polyunsaturated fatty acids, a matrix of nutrients with cardiovascular benefits Santos HO, May TL, Bueno AA
Review Article Cardiovascular Disease Cholesterol High Blood Pressure
The abstract primarily acknowledges the importance of Omega-3 polyunsaturated fatty acids with respect to managing diseases related to heart health and metabolism, for instance, type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. However, these fatty acids are not the sole beneficial component of sardines. Minerals including but not limited to calcium, potassium, and magnesium as well as substances like taurine and arginine found in sardines have a significant role in controlling mild inflammation and oxidative stress which are usually present in cardiovascular diseases and hemodynamic dysfunction.
The results discussed in the abstract suggest a positive correlation between consumption of sardines and potential cardiometabolic benefits. By considering the dose-response relationship effects, a pragmatic approach towards consumption of nutrients was suggested. The intake of sardines was seen not only as a means of Omega-3 supplementation but also as a comprehensive approach to enhancing cardiovascular health. The abstract concludes with an emphasis on the many beneficial nutrients found in sardines besides Omega-3, underlining the need to shift the focus from synthetic supplementation to natural dietary improvement.
Nutrition, particularly an anti-inflammatory Mediterranean diet supplemented with oily fish and omega-3 supplements, can potentially reduce inflammation and improve symptoms of rheumatoid arthritis.
2023 Autoimmunity Reviews Nutrition and its role in prevention and management of rheumatoid arthritis Nikiphorou E, Philippou E
Review Article Mediterranean Diet Omega-3 Fatty Acids Sardine
The review examines evidence indicating a possible connection between nutrition and the risk and management of rheumatoid arthritis, an autoimmune disease having an immune-inflammatory response. The impact of different food types was considered, including pro-inflammatory and anti-inflammatory foods. Specifically, the research highlights the effectiveness of a Mediterranean diet, rich in fish and supplemented with omega-3 polyunsaturated fatty acids, in reducing inflammation and oxidation. Other factors such as herbs and spices, beverages, vitamin D, and probiotics were also taken into account. The research emphasizes the direct and indirect role of nutrition through the management of co-morbidity.
The disease activity was observed to improve with dietary changes, particularly a propensity to reduce inflammation, oxidation, and beneficial effects on gut microbiota. An anti-inflammatory Mediterranean diet, supplemented with consumption of oily fish at least twice a week, and daily intake of omega-3 polyunsaturated fatty acid supplements of 2 g, has been recommended. The study also highlights the importance of rheumatologists working closely with registered dietitians to support patients in managing a well-balanced diet according to their individual needs.
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
2023 PharmaNutrition Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits Tan ST, Tan SS, Tan CX
Review Article Cholesterol High Blood Pressure Isoflavone
Methodology: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. It began with a sophisticated multi-database search, featuring resources like Google Scholar, Scopus, and others. This search targeted articles published from 2017 to March 2023 and used specific keywords for accuracy. Forty-three articles were handpicked from this process after excluding reviews, conference reports, duplicates, inaccessible texts, and any non-English publications.
Discussion of Results: A thorough examination of the chosen articles resulted in the conclusion that soy proteins, soy bioactive peptides, and soy isoflavones are typically safe for human consumption. Furthermore, it was found that the consumption of these compounds may have beneficial effects, potentially lowering risk factors for ailments such as osteoporosis, various cancers, hypertension, atherosclerosis, and more.
A one-year, sardine-enriched diet in an elderly population with pre-diabetes exerts a greater protective effect against developing type 2 diabetes and cardiovascular events.
2021 Clinical Nutrition Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial Díaz-Rizzolo DA, Serra A, Colungo C, Sala-Vila A, Sisó-Almirall A, Gomis R
Randomised Controlled Trial Anti-Diabetic Cardiovascular Disease Diabetes
Following the nutrition intervention, 29.6% of SG subjects had left the "very high" risk group (from 37.3% to 7.7%), while only 4.9% of CG subjects had managed to do so (from 27.3% to 22.4%), a finding which is significantly different.
Eating sardines twice a week for a year significantly reduces the risk of developing type 2 diabetes in prediabetic individuals aged 65 and above.
2021 Clinical Nutrition Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial Díaz-Rizzolo DA, Serra A, Colungo C, Sala-Vila A, Sisó-Almirall A, Gomis R
Randomised Controlled Trial Anti-Diabetic Cardiovascular Disease Diabetes
In this study, 152 individuals with prediabetes and age 65 or older were chosen from three primary care centers in Barcelona. These subjects had a fasting glucose of 100-124 mg/dL. They were divided into two intervention groups: a control group (CG) and a sardine group (SG). While both groups were given the same nutritional diet to prevent type 2 diabetes for a year, the sardine group was instructed to include 200 grams of sardines in their diet every week. Data including fasting glucose levels, type of diet followed, and other demographic variables were collected before starting and after ending the diet.
After a year, the sardine group, when compared to the control group, showed significant reductions in the percentage of individuals classified as very high risk for developing type 2 diabetes. The sardine group also showed improved health parameters such as increased HDL-cholesterol and adiponectin levels, decreased triglyceride levels, and slightly reduced blood pressure. Additionally, the consumption of sardine nutrients - omega-3, EPA and DHA, vitamin D, fluorine, and taurine - was significantly higher in the sardine group. Further, changes in erythrocyte membrane fatty acids were detected only in the sardine group, which included a decrease in 5 omega-6 fatty acids and an increase in 3 omega-3 fatty acid types.
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