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Luteolin, found in chrysanthemum flower extract, can potentially reduce serum uric acid levels, suggesting it may help prevent gout.
The research involved two double-blind placebo-controlled studies examining the impacts of chrysanthemum flower extract enriched with luteolin on serum uric acid levels. In a single-dose study, fasting participants consumed a capsule loaded with the luteolin-rich extract before partaking in a high purine meal, with uric acid levels evaluated over time. The second study involved repeated consumption of the capsule over a 4-week period, with fasting serum uric acid measured before and after consumption.
The research found that although luteolin did not significantly affect uric acid levels immediately after consumption, there was an observed decrease in these levels following four weeks of continued ingestion. Most notably, subjects with a baseline uric acid level between 5.5 to 7.0 mg/dL saw a significant reduction after they consumed chrysanthemum flower extract. The trial also established that no adverse effects resulted from the ingestion of the extract.
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A daily dose of Chrysanthemum flower extract was found to significantly reduce serum uric acid levels, potentially improving hyperuricemia.
2022 Functional Foods in Health and Disease Effects of luteolin-rich chrysanthemum flower extract on purine base absorption and blood uric acid in Japanese subjects Takara T, Yamamoto K, Suzuki N, Yamashita S, Iio S, Kakinuma T, et al.
Randomised Controlled Trial Chrysanthemum Luteolin Uric Acid
In the methodology, two studies were conducted where 44 healthy Japanese men and women with slightly elevated serum uric acid levels were split into two groups, active and placebo, using a randomized computerized system. The active group received 100mg of Chrysanthemum flower extract containing 1mg of luteolin. In the first study, purine naturally found in food was ingested alongside the flower extract, and the participants' serum uric acid levels were measured over time. In the second study, the extract or a placebo was taken daily over 12 weeks. Changes in uric acid levels were the primary outcome, and blood, urine, and body parameters were checked to confirm the safety of the extract.
For the results, in the first study, there were no significant differences found in serum uric acid levels between the group that consumed the extract and the placebo group following a purine-rich meal. However, in the second study spanning 12 weeks, the group that took the Chrysanthemum flower extract had significantly lower uric acid levels than the placebo group. Safety tests showed no adverse effects from taking the extract.
A combination of extracts from chrysanthemum were found to be more effective in treating hyperuricemia and potentially developing anti-hyperuricemic functional foods.
2021 Plants Hypouricemic Effects of Chrysanthemum indicum L. and Cornus officinalis on Hyperuricemia-Induced HepG2 Cells, Renal Cells, and Mice Kim OK, Yun JM, Lee M, Kim D, Lee J
Network Pharmacology Chrysanthemum Cornus Officinalis Hypouricemic Effects
The methodology used in this study involved treating human liver cancer cells, mouse renal proximal tubule cells and hyperuricemic mice with uric acid extracted from two different plants, specifically L. (Ci) and Siebold and Zucc. (Co). It was found that the extracts from these two plants, both individually and in combination, suppressed the activity of certain enzymes involved in uric acid metabolism and influenced the expression of corresponding proteins.
In discussing the results, the study identified that the combined effect of these two extracts was significantly stronger in suppressing uric acid accumulation compared to using each extract on its own. This was evidenced by an increased excretion of waste products associated with uric acid metabolism when using the combination of Ci and Co. There was also a decrease in the expression of certain proteins that facilitate uric acid accumulation. Therefore, the data suggests that a mixture of Ci and Co extracts could be effective in developing functional foods to combat hyperuricemia.
DKB114, a mixture of Linn flower extract, effectively reduces serum uric acid level, suggesting its potential as a dietary supplement for hyperuricemia treatment.
2020 Nutrients A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial for Evaluation of the Efficacy and Safety of DKB114 on Reduction of Uric Acid in Serum Park YH, Kim DH, Lee JS, Jeong HI, Lee KW, Kang TH
Randomised Controlled Trial Gout Hyperuricemia Uric Acid
The research employed a randomized, double-blind, placebo-controlled clinical trial conducted across a span of 12 weeks. A total of 80 asymptomatic hyperuricemic subjects (serum uric acid level between 7.0-9.0 mg/dL) were selected and equally split into two groups. One group was administered DKB114, the investigational mixture of extracts, while the other group received a placebo.
After six weeks of administration, the levels of serum uric acid were evaluated, revealing no significant difference between the two groups. By the end of the 12th week, however, subjects in the DKB114 group exhibited a noticeably larger decrease in their serum uric acid levels when compared to the placebo group. Additionally, various other health indicators including C-reactive protein and apoprotein B levels showed significant trends favoring DKB114.
Further evaluations during the trial included clinical pathological tests, weight measurements and vital signs, and electrocardiogram tests which confirmed the safety of DKB114. No significant harmful effects or differences were detected in comparison to the placebo group. This concludes the positive impact and safe use of DKB114 for patients with elevated serum uric acid levels.
Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products.
2019 Evidence-Based Complementary and Alternative Medicine Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review Chen PE, Liu CY, Chien WH, Chien CW, Tung TH
Systematic Review Cherry Gout Uric Acid
The six studies included in this systematic review reported decreases in the incidence and severity of gout following the ingestion of cherries. Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. Overall, we observed a positive correlation between the consumption of tart cherry juice and a decrease in serum uric acid concentration.
A mixture of Chrysanthemum indicum Linne flower and Cinnamomum cassia significantly mitigates hyperuricemia in rats by inhibiting xanthine oxidase activity and enhancing uric acid excretion.
2017 Evidence-Based Complementary and Alternative Medicine Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts Lee YS, Son E, Kim SH, Lee YM, Kim OS, Kim DS
Network Pharmacology Chrysanthemum Gout Uric Acid
In this experiment, the authors evaluated the impact of a combined extract from Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (CB) on hyperuricemia, a condition associated with excessive uric acid in the bloodstream. The study was conducted on both normal and hyperuricemic rats induced by potassium oxonate. Uric acid levels and renal excretion were primarily measured to analyse the potential antihyperuricemic properties of the CF and CB mix.
From the experiment, it was found that the CF and CB blend led to a significant reduction in uric acid levels in both normal and hyperuricemic rats, with the effect being stronger compared to either CF or CB in isolation. Additionally, the mixture caused an increase in uric acid elimination through the kidneys in the hyperuricemic rats, pointing to its potential antihyperuricemic action. It was also discovered that the mixture and its primary components, namely, chlorogenic acid, isochlorogenic acid, coumarin, cinnamaldehyde, trans-cinnamic acid, and o-methoxycinnamaldehyde, mitigated the action of xanthine oxidase (an enzyme that accelerates uric acid production) in vitro. This partial xanthine oxidase inhibition sheds light on the underlying mechanism of the antihyperuricemic effect by the CF and CB mixture.
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