Insights & Discussion
DKB114, a mixture of Linn flower extract, effectively reduces serum uric acid level, suggesting its potential as a dietary supplement for hyperuricemia treatment.
The research employed a randomized, double-blind, placebo-controlled clinical trial conducted across a span of 12 weeks. A total of 80 asymptomatic hyperuricemic subjects (serum uric acid level between 7.0-9.0 mg/dL) were selected and equally split into two groups. One group was administered DKB114, the investigational mixture of extracts, while the other group received a placebo.
After six weeks of administration, the levels of serum uric acid were evaluated, revealing no significant difference between the two groups. By the end of the 12th week, however, subjects in the DKB114 group exhibited a noticeably larger decrease in their serum uric acid levels when compared to the placebo group. Additionally, various other health indicators including C-reactive protein and apoprotein B levels showed significant trends favoring DKB114.
Further evaluations during the trial included clinical pathological tests, weight measurements and vital signs, and electrocardiogram tests which confirmed the safety of DKB114. No significant harmful effects or differences were detected in comparison to the placebo group. This concludes the positive impact and safe use of DKB114 for patients with elevated serum uric acid levels.
Discover Related Insights
A daily dose of Chrysanthemum flower extract was found to significantly reduce serum uric acid levels, potentially improving hyperuricemia.
2022 Functional Foods in Health and Disease Effects of luteolin-rich chrysanthemum flower extract on purine base absorption and blood uric acid in Japanese subjects Takara T, Yamamoto K, Suzuki N, Yamashita S, Iio S, Kakinuma T, et al.
Randomised Controlled Trial Chrysanthemum Luteolin Uric Acid
In the methodology, two studies were conducted where 44 healthy Japanese men and women with slightly elevated serum uric acid levels were split into two groups, active and placebo, using a randomized computerized system. The active group received 100mg of Chrysanthemum flower extract containing 1mg of luteolin. In the first study, purine naturally found in food was ingested alongside the flower extract, and the participants' serum uric acid levels were measured over time. In the second study, the extract or a placebo was taken daily over 12 weeks. Changes in uric acid levels were the primary outcome, and blood, urine, and body parameters were checked to confirm the safety of the extract.
For the results, in the first study, there were no significant differences found in serum uric acid levels between the group that consumed the extract and the placebo group following a purine-rich meal. However, in the second study spanning 12 weeks, the group that took the Chrysanthemum flower extract had significantly lower uric acid levels than the placebo group. Safety tests showed no adverse effects from taking the extract.
A combination of extracts from chrysanthemum were found to be more effective in treating hyperuricemia and potentially developing anti-hyperuricemic functional foods.
2021 Plants Hypouricemic Effects of Chrysanthemum indicum L. and Cornus officinalis on Hyperuricemia-Induced HepG2 Cells, Renal Cells, and Mice Kim OK, Yun JM, Lee M, Kim D, Lee J
Network Pharmacology Chrysanthemum Cornus Officinalis Hypouricemic Effects
The methodology used in this study involved treating human liver cancer cells, mouse renal proximal tubule cells and hyperuricemic mice with uric acid extracted from two different plants, specifically L. (Ci) and Siebold and Zucc. (Co). It was found that the extracts from these two plants, both individually and in combination, suppressed the activity of certain enzymes involved in uric acid metabolism and influenced the expression of corresponding proteins.
In discussing the results, the study identified that the combined effect of these two extracts was significantly stronger in suppressing uric acid accumulation compared to using each extract on its own. This was evidenced by an increased excretion of waste products associated with uric acid metabolism when using the combination of Ci and Co. There was also a decrease in the expression of certain proteins that facilitate uric acid accumulation. Therefore, the data suggests that a mixture of Ci and Co extracts could be effective in developing functional foods to combat hyperuricemia.
Cinnamomum cassia, or cinnamon, exhibits promising therapeutic benefits in combating gastritis by targeting inflammation pathways, according to preclinical studies.
2021 Applied Biological Chemistry Potential and beneficial effects of Cinnamomum cassia on gastritis and safety: Literature review and analysis of standard extract Lee JH, Park DH, Lee S, Seo HJ, Park SJ, Jung K, et al.
Review Article Chinese Cinnamon Gastritis
This study is a systematic review of 20 studies evaluating the pharmacological effects and mechanisms of C. cassia in treating gastritis. Focusing on the main active compound of C. cassia, cinnamaldehyde, the research was centered around its influence on inflammation pathways. Furthermore, different methodologies were used to induce gastric ulcers, including stress, alcohol, excessive acidity, and the prolonged usage of non-steroidal anti-inflammatory drugs (NSAIDs).
The result discussion highlights the success C. cassia extract demonstrated in protecting against gastritis. Key findings stemmed from preclinical tests, with predominantly animal models, including Beagle dogs and rats. The ingestion of standardized C. cassia extracts showed positive effects with no toxicity, asserting the effectiveness and safety of this natural remedy in managing gastritis.
Cinnamon supplementation can improve blood pressure by a modest degree.
2020 Clinical Nutrition ESPEN The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials Hadi A, Campbell MS, Hassani B, Pourmasoumi M, Salehi-sahlabadi A, Hosseini SA
Systematic Review Chinese Cinnamon High Blood Pressure
Meta-analysis of 9 RCTs with 641 participants showed significant reductions in both systolic (WMD: −5.17 mmHg, 95% CI: −9.35 to −0.99, P = 0.01) and diastolic blood pressure (WMD: −3.36 mmHg, 95% CI: −5.67 to −1.04, P ≤ 0.001) after cinnamon supplementation. Subgroup analyses indicated that these results were significant only when cinnamon was administered at the dosages of ≤2 g/day, for a period longer than 8 weeks, and in participants with a baseline BMI of ≥30 kg/m2.
Cinnamon supplementation significantly decreases inflammation and oxidative stress levels, serving as a potential additive for cardiometabolic health improvement.
2020 Complementary Therapies in Medicine Impact of Cinnamon Supplementation on cardiometabolic Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Zhu, Changyou; Yan, Hongmei; Yin, Zheng; Santos, Heitor O; Melahat Sedanur Macit; et al
Systematic Review Anti-Inflammatory Antioxidant Chinese Cinnamon
The systematic review and meta-analysis followed the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines. A comprehensive search for appropriate clinical trials was performed across multiple databases including PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, and Google Scholar until January 2020. After duplicates were removed, 1145 studies were found eligible and 12 studies were finally included in the meta-analysis, investigating the impact of cinnamon supplementation dosages ranging between 1.5 to 4 grams per day.
The results of the meta-analysis revealed that cinnamon supplementation led to a significant reduction in inflammation markers, C-reactive protein and interleukin-6, alongside a decrease in malondialdehyde, an oxidative stress marker. Concurrently, an increase was observed in the total antioxidant capacity following the supplementation, implying an enhancement in the body's defensive ability against oxidative damage. Nevertheless, no significant change was identified in the levels of intercellular adhesion molecule-1 after the cinnamon supplementation.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.