Consuming two SunGold kiwifruits daily over 12 weeks improved vitamin C status, reduced blood pressure, waist measurements and altered faecal microbiota composition in prediabetic individuals.
Randomised Controlled Trial Gut Microbiota High Blood Pressure Kiwifruit
Over a 12 week pilot intervention trial, people with prediabetes were observed after consuming two SunGold kiwifruits per day. Participants filled out a physical activity questionnaire and a three-day estimated food diary at both the commencement and end of the trial. Venous blood samples were collected at the start, in between (at 6 weeks) and at the end of the trial, to observe glycaemic indices, plasma vitamin C concentrations, hormones, lipid profiles and high-sensitivity C-reactive protein levels. Additionally, participants provided faecal samples at each visit for DNA extraction and subsequent amplification and sequencing of a region of the 16S ribosomal RNA gene to determine faecal microbiota composition.
The differences were then compared between week 12 and their baseline measurements revealing a significant increase in plasma vitamin C concentration. Further changes including significant reductions in both diastolic and systolic blood pressure as well as waist circumference and waist-to-hip ratio were recorded. Despite recording a slight drop in HbA1c levels and a minor increase in fasting glucose, the changes were small and not clinically significant. Moreover, the composition analysis of the faecal microbiota indicated an increase in the relative abundance of hitherto uncultivated, hence uncharacterised members of a particular bacterial family. These findings suggest that these unknown bacterial members could potentially have a functional relationship with the polysaccharides and polyphenols in kiwifruits.
View Article