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Pomegranate juice consumption appears to somewhat enhance inflammatory status and complete blood count in hospitalized COVID-19 patients.
2023 Complementary Therapies in Medicine Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients: A randomized and placebo-controlled trial Yousefi M, Sadriirani M, Mahmoodi S, Samimi B, Pourmahmoudi A, Hosseinikia M, et al.
Randomised Controlled Trial Common Cold, Flu & Viral Infections COVID-19 CRP
The study was a randomized, double-blinded placebo-controlled trial involving 48 patients and had two parallel arms. As part of their standard hospital care, patients were either given 500 mL of whole pomegranate juice daily or a placebo for a period of 14 days. The researchers focused on measuring inflammatory indicators and complete blood counts both at the start of the study and at the end of the 14-day intervention period.
Following the 14-day intervention, there was a distinguishable decrease in primary outcomes including inflammatory markers such as C reactive protein, interleukin-6, and erythrocyte sedimentation rate in the group that consumed pomegranate juice as compared to the readings before the intervention. In addition, considerable changes were also observed in secondary outcomes such as neutrophils, lymphocytes, platelets, platelets-to-lymphocyte and neutrophils-to-lymphocyte ratios in the pomegranate juice group compared to the parameters before the intervention. Finally, the mean changes in levels of interleukin-6, white blood cells, neutrophils, lymphocyte, platelets, platelets-to-lymphocyte ratio, blood oxygen saturation and MCV were significantly different between the two groups by the end of intervention, while no significant difference was noted in other blood indices.
Ginger supplementation can prevent ethanol-induced reproductive dysfunction by improving hormone levels, reducing oxidative damage, inflammation, and regulating genes involved in testosterone synthesis.
2021 Brazilian Archives of Biology and Technology Ginger (Zingiber officinale Roscoe) Improves Ethanol-Induced Reproductive Dysfunction by Enhancing Steroidogenesis and Inhibiting Oxidative Stress and Inflammation Li N, Xing Y, Sultan AH, Raeeszadeh M, Akbari A, Liu H
Experimental Study Ginger Inflammation Oxidative Stress
The methodology involved twenty-four adult male rats divided into four groups for a 28-day experiment. The researchers administered either ethanol or ginger extract to respective groups and then measured varying physiological factors related to reproductive health such as testosterone levels, antioxidant enzyme activity, concentrations of tumor necrosis factor-alpha, and gonadotropins hormones. In addition, gene expressions related to oxidative damage, inflammation, and testosterone synthesis were also examined.
Animating the discussion of results, it was observed that the administration of ethanol significantly decreased levels of hormones, oxidative markers, and lowered gene expression involved in testosterone synthesis. Conversely, ethanol caused an increase in inflammatory markers and the expression of genes related to inflammation. On the other hand, rats given a ginger supplement positively reversed these effects, showing significant improvements in all factors, thus leading to the conclusion that ginger can prevent reproductive issues induced by ethanol. The results obtained from the histological study further confirmed these findings, reaffirming that ginger could effectively counter ethanol-induced reproductive dysfunction.
Certain oxylipins, which are bioactive lipids derived from omega-6 and omega-3 polyunsaturated fatty acids, are potential key influencers in arthritis in older adults.
2020 The Journals of Gerontology: Series A Imbalance Between Omega-6- and Omega-3-Derived Bioactive Lipids in Arthritis in Older Adults Coras R, Pedersen B, Narasimhan R, Brandy A, Mateo L, Prior-Español A, et al.
Cohort Study Omega-6 Omega-3 Ratio Rheumatoid Arthritis
The research method involved an observational prospective study of 64 patients over the age of 60 with newly diagnosed arthritis, which was categorized as Elderly-onset rheumatoid arthritis and polymyalgia rheumatica. Patients' blood samples were taken at the start of the study and 3 months post-treatment, with results compared to 18 control samples. A thorough clinical examination was conducted for each patient. Serum oxylipins (bioactive lipids derived from omega-6 and omega-3 polyunsaturated fatty acids) were determined through mass spectrometry, and data analysis was performed.
In the discussion, it was found that the levels of certain oxylipin species were significantly different between control subjects and arthritis patients. Interestingly, the ratio of omega-3 to omega-6 polyunsaturated fatty acids was significantly downregulated in elderly-onset rheumatoid arthritis patients compared to controls. Two oxylipins, namely hydroxydocosahexaenoic acid and dihydroxy-eicosatrienoic acid, were identified as top candidates for differentiating polymyalgia rheumatica from elderly-onset rheumatoid arthritis. Following treatment, the levels of omega-3 derived anti-inflammatory species increased in elderly-onset rheumatoid arthritis patients.
Pomegranate juice supplementation notably diminishes inflammation and vascular dysfunction markers in adults, offering potential cardiovascular health benefits.
2020 Complementary Therapies in Medicine The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review Wang P, Zhang Q, Hou H, Liu Z, Wang L, Rasekhmagham R, et al.
Meta-Analysis Endothelial Dysfunction Inflammation Pomegranate
The research used a broad approach, systematically reviewing and performing a meta-analysis of 16 randomised controlled trials including 572 participants, as per the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. Relevant articles and references were found via the PubMed/Medline and SCOPUS databases, with screening carried out up until May 2019. The studies explored the impact of pomegranate juice supplements.
The discussion reveals that pomegranate supplementation conspicuously reduced the levels of certain pro-inflammatory and vascular dysfunction markers. However, the research found no significant reduction in some other markers when compared to a placebo. Despite not all markers recording significant reduction, the overall findings strongly suggest pomegranate supplements as a viable tactic for reducing inflammation in adults, potentially offering cardiovascular health advantages.
Daily consumption of tart cherry juice for 12 weeks showed anti-oxidative and anti-inflammatory properties which may reduce blood pressure and lower LDL cholesterol in older adults.
2019 Nutrients Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults Chai S, Davis K, Zhang Z, Zha L, Kirschner K
Randomised Controlled Trial Cherry High Blood Pressure Inflammation
In the randomized-controlled clinical trial conducted, 37 participants aged between 65 and 80 were given either 480 mL of tart cherry juice or a control drink to consume daily for a span of 12 weeks. Blood biomarkers linked to inflammation and oxidative stress were analyzed both at the start and after the 12 weeks intervention.
Post the intervention period, levels of several inflammation and oxidative stress blood biomarkers in the tart cherry juice group observed notable differences compared to the control group. Particularly, a perceivable elevation in DNA repair activity coupled with a reduced mean c-reactive protein level was seen. Furthermore, a significant group effect was seen in plasma levels of c-reactive protein and malondialdehyde, with a slightly less significant effect observed for oxidized low-density lipoprotein. Post- intervention plasma levels showed a decreasing trend, with c-reactive protein, malondialdehyde, and oxidized low-density lipoprotein falling by 25%, 3%, and 11% respectively compared to the baseline values.
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