This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
Insights & Discussion
Vincentka natural mineral water reduces gastric damage and improves antioxidant capacity in an animal model of acute gastric ulcers.
This pilot study involved 16 male Wistar rats, divided into two groups: an experimental group and a control group, each with eight rats. The study was conducted in three phases: a 7-day handling phase, a 7-day phase where the experimental group received Vincentka mineral water and the control group received tap water, and a final phase of acute gastritis induction lasting one day. After 24 hours post-induction, the animals were sacrificed for analysis. Tissue samples from the stomach and duodenum, as well as blood samples, were examined using histological microscopy, immunohistochemical, and biochemical methods.
The histopathological analysis showed significantly less damage to the stomach lining in the experimental group compared to the control group. There were notable differences in blood plasma antioxidant capacity, oxidative stress parameters, and other biochemical values between the groups. These findings indicate that Vincentka mineral water positively affects the development and symptoms of acute gastric ulcers in this animal model, suggesting potential benefits for similar human conditions.
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Natural calcium-rich mineral waters offer a bioavailable calcium source, beneficial for bone health, cardiovascular function, weight management, and overall well-being.
2023 Nutrients Exploring the Potential Benefits of Natural Calcium-Rich Mineral Waters for Health and Wellness: A Systematic Review Pop MS, Cheregi DC, Onose G, Munteanu C, Popescu C, Rotariu M, et al.
Systematic Review Bone Health Calcium High Blood Pressure
This systematic review analyzed peer-reviewed articles, clinical trials, and experimental studies from the past decade. It focused on the health benefits of calcium-rich mineral waters, especially for individuals with lactose intolerance or on plant-based diets. The review process assessed the contribution of these waters to daily calcium intake and their bioavailability compared to other calcium sources.
The review found that natural mineral waters high in calcium can significantly enhance calcium intake, with improved absorption rates. These waters show promise in promoting bone health and cardiovascular function, including potential reductions in blood pressure and cardiovascular disease risk. Some evidence suggests benefits in weight management. However, the review highlighted the need for further research on interactions with other dietary components, effects on specific health conditions, and long-term consumption impacts. Despite these gaps, calcium-rich mineral waters are recognized as a valuable dietary calcium source for a diverse population.
Magnesium-rich mineral water effectively treats and prevents constipation in children, leading to regular, painless bowel movements.
2020 Russian Journal of Physiotherapy, Balneology and Rehabilitation The use of magnesium-containing mineral waters for functional constipation in children and adolescents Kulikov AG, Zakharova IN, Tvorogova TM, Stepurina LL, Elezova LI
Clinical Study Magnesium Magnesium-containing Mineral Water
This randomized, prospective, open, comparative study involved 95 children and adolescents aged 10-16 years with functional constipation. They received sanatorium therapy for 18 days, including a sparing-exercise regimen, therapeutic nutrition, health-improving massage, and physiotherapy exercises. Participants were divided into two groups: Group 1 (55 patients) received basic treatment plus magnesium-containing mineral water, while Group 2 (40 patients) received only basic treatment. The study assessed the frequency and nature of defecation, vegetative status, and functional body reserves.
By day 5, 49% of Group 1 patients achieved daily defecation, increasing to 89.1% by the end of treatment. In contrast, only 55% of Group 2 showed positive changes by the end. The mineral water group also had softer, pain-free bowel movements, with most achieving a morning defecation reflex after consuming the water. The control group saw less significant changes in defecation nature, with only 18% reaching softer bowel movements by the end of treatment. The results indicate the effectiveness and safety of magnesium-containing mineral water in treating and preventing functional constipation in children.
Honey exhibits significant anti-Helicobacter pylori activity, with at least 10% concentration proving effective in inhibiting gastric and duodenal ulcers, highlighting its therapeutic potential.
2020 Sains Malaysiana In vitro Study of Anti-Helicobacter pylori Activity of Honey: A Systematic Review Adam Q, Annuar F, Alfizah H, Mohd Fahami NA
Systematic Review Gastritis H Pylori Honey
The research involved a comprehensive review of 53 articles from electronic databases such as Medline via Ovid Medline, Scopus, and ScienceDirect spanning from 2000 to 2018. Selection criteria focused on studies reporting honey's effects on H. pylori-induced gastric and duodenal ulcers. Nine chosen articles detailed the positive impact of honey, suggesting a minimum 10% concentration as effective against H. pylori. The review underscores the need for further exploration into honey's active components and molecular mechanisms.
The positive outcomes reported in selected studies support honey's potential in inhibiting H. pylori infections, emphasizing the need for further investigations to elucidate the active components and underlying molecular mechanisms. The review sets the stage for future research aiming to provide robust evidence for the use of honey in clinical settings.
Mineral water increases the diversity of gut microbiota by aiding the growth of Bacteroidetes taxa.
2020 Journal of Water and Health The effect of different drinking water in culture medium on feces microbiota diversity Zhou K, Liu W, Chen Z, Yang D, Qiu Z, Feng H, et al.
Experimental Study Bacteriodetes Gut Microbiota Mineral Water
The researchers carried out the study on BALB/c mice, focusing specifically on the bacterial community in their feces and how it responds to different types of drinking water. These types included commercial bottled mineral water, natural water, purified water, and tap water. After culturing the feces in a combination of brain heart infusion broth dissolved in the four water types, they conducted a 16S rRNA gene analysis to study the bacterial composition.
The bacterial composition varied significantly between the four different types of drinking water. Over time, the overall number of Operational Taxonomic Units (OTUs) decreased, with the exception of cultures grown in mineral water under aerobic conditions. Under these conditions, by the fifth day, alpha diversity differences were particularly noticeable when comparing mineral water with the other types. The most unique taxa were found within the mineral water group. Notably, the Bacteroidetes taxa showed the most significant differences, dominating in the mineral water compared to the other types of water. This indicates that using mineral water as a culture medium could lead to a progressive increase in gut microbiota diversity.
Hépar mineral water, rich in sulphates and magnesium, effectively treats functional constipation, showing significant results within 7 days.
2019 Nutrition Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, Kapel N
Clinical Study Mineral Water
In this multicenter, randomized, double-blind, controlled study, 226 outpatients with functional constipation were evaluated. Participants underwent a washout period before consuming 1.5 liters of water daily for 14 days, of which 1 liter was either Hépar or low-mineral water. Patients self-reported stool consistency daily, and an expert investigator, blinded to the treatment groups, evaluated stool consistency using the Bristol stool scale based on patient-provided photographs.
The study successfully met its primary endpoint, with 50% of participants in the Hépar group responding to treatment by day 14, compared to 29% in the control group. The average time to observe a treatment response was 6.4 days for Hépar users, shorter than the 7.3 days in the control group. Approximately 60% of patients provided stool scores, with 79% of these scores closely aligning between patients and experts. The safety analysis of Hépar indicated excellent results, confirming its efficacy and safety in treating functional constipation.
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