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Adzuki bean exhibited the strongest antiproliferative properties in a dose-dependent manner against all digestive system cancer cell lines, ovary cancer cell SK-OV-3 and breast cancer cell MCF-7 among all legumes tested.
This research involved comparing the health-promoting effects of various food legumes. The Cellular Antioxidant Activity (CAA) was assessed using a fluorescence microplate reader and in vitro animal cell cultivation. The antiproliferative properties against cancer cells were evaluated through the MTT method in an in vitro cell culture system. Additionally, the study quantified phytochemicals (total phenolic, procyanidin, saponin, and phytic acid) and chemical antioxidant activities (DPPH free radical scavenging activity, oxygen radical absorbing capacity, peroxyl radical scavenging capacity).
The results indicated significant variations in phytochemical and antioxidant activities among different legumes. Notably, adzuki bean demonstrated the strongest dose-dependent antiproliferative effects against various cancer cell lines, including those from the digestive system, ovary, and breast. Meanwhile, black soybean showed the highest levels of saponin, phytic acid, and the strongest cellular antioxidant activities. These findings suggest that food legumes, particularly adzuki beans and black soybeans, are promising as natural antioxidants for health promotion and cancer prevention.
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Pumpkin seeds are recognised for their medicinal, nutritional, and cosmetic benefits, including anti-diabetic, heart disease prevention, anti-cancer, and antioxidant qualities.
2024 The Natural Products Journal Pumpkin Seeds (Cucurbita spp.) as a Nutraceutical Used In Various Lifestyle Disorders Wal A, Singh MR, Gupta A, Rathore S, Rout RR, Wal P
Review Article Anti-Parasite Anticancer Antioxidant
The review article undertakes a comprehensive exploration of the nutraceutical importance of pumpkin seeds. The methodology includes an examination of the various known substances in the seeds, such as phytoestrogens, unsaturated fatty acids, and vitamin E. The study then delves into the different benefits and therapeutic uses of these components stretching from medicinal to nutritional to cosmetic applications.
The results of this research are diverse and impressive, with implications for several major health sectors. Their potential anti-diabetic and hypoglycemic properties could suggest a significant role in the management and prevention of diabetes. Meanwhile, the seeds' potential in cardiovascular disease prevention could help to address one of the most pressing global health issues. Moreover, potential anti-cancer properties imply that these seeds could even have a part to play in cancer prevention. The review also described potential additional qualities, such as antidepressant, anti-helminthic (parasite-removing), and antioxidant effects.
Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.
2023 Journal of the Science of Food and Agriculture Carrot and carotene and multiple health outcomes: an umbrella review of the evidence Yi X, Li J, Liao D, Peng G, Zheng X, Xu H, et al.
Review Article Alzheimer's Disease Anticancer Breast Cancer
An umbrella review methodology was adopted to identify connections between carrot and carotene intake and various health outcomes. We turned to databases such as Web of Science, PubMed, and Embase to find the needed data. The analysis included the collected evidence from both interventional and observational studies that focused on carrots, carotene, and any related health impact. To estimate the summary effect size for each correlation, both random and fixed effects models were employed.
The study reviewed a total of 1329 studies and utilized the data from 30 meta-analyses with 26 health outcomes that fit the eligibility requirements. These featured outcomes related to various types of cancer, fractures, age-related cataract, sunburn, and Alzheimer's disease. The associations were analyzed between the health outcomes and the intake of carrots, intake of carotene, and serum carotene levels.
Crocin, a compound derived from saffron, has shown considerable potential in hindering tumor growth and improving immune status, across various malignant tumors.
2023 PeerJ Advances on the anti-tumor mechanisms of the carotenoid Crocin Bao X, Hu J, Zhao Y, Jia R, Zhang H, Xia L
Review Article Anti-Tumour Breast Cancer Cervical Cancer
The methodology for the study involved an in-depth review of modern pharmacological studies that have analyzed the therapeutic effects of crocin, a natural compound that can be extracted from saffron. Various anti-tumor effects were assessed including the induction of tumor cell death (apoptosis), restrictions on tumor cell proliferation, and potential barriers to invasion and metastasis of these cells. The potential for enhancement of sensitivity to chemotherapy and improvement of immune status were also examined.
Following the review, the study revealed that crocin has significant anti-tumor properties. It showed that this natural compound can induce apoptosis in tumor cells, inhibit their expansion and progression, and even prevent their invasiveness and metastasis. Furthermore, crocin demonstrated the potential to enhance the body’s responsiveness to chemotherapy and help boost the immune system. These effects were observed across a range of different malignant tumors, including stomach, liver, cervical, breast, and colorectal cancers.
The jujube tree bears fruit endowed with substantial nutritional value and contains numerous phytochemical components with reported antioxidant, anti-cancer and neuroprotective properties.
2022 Traditional Medicine Research Jujube (Ziziphus jujuba Mill. (Rhamnaceae)): a review on its pharmacological properties and phytochemistry Aafi E, Reza M, Mirabzadeh M
Theoretical Article Anticancer Antioxidant Jujube
The research implemented an analysis of the jujube tree, its fruit, and its long history of usage in traditional medicine, focusing primarily on its use in traditional Persian and Chinese medicines. The varied geographical distribution of the tree was studied, especially its presence in tropical and subtropical regions across Europe and Asia. Researchers took into account the tree’s resilience to soil salinity and alkalinity as part of its general characteristics.
The core of the study involved an in-depth investigation into the nutritional composition and pharmacological properties of the jujube fruit. The fruit's contents were categorized into proteins, minerals, vitamins, organic acids, and carbohydrates. Furthermore, a range of phytochemical components such as polyphenols, flavonoids, terpenoids, anthocyanins, alkaloids, and carotenoids were identified.
Research noted both the fruit's nutraceutical and cosmeceutical potential. It also explored the medicinal properties of all elements of the plant, not just the fruit.
The physiological impacts of the jujube were also evaluated across various medical contexts, seeking to understand its impact on different organs and tissues, as well as its influence on various health conditions and concerns. Culminating in the identification of antioxidant, anti-cancer, antimicrobial, neuroprotective, cardioprotective, hepatoprotective properties. Noteworthy, are also its health-promoting effects, with strong references to anti-aging properties.
Chrysanthemums, popular floricultural crops, not only hold significant ornamental value but also exhibit various therapeutic potentials including antioxidant, antimicrobial, and anticancer activities.
2022 South African Journal of Botany Chrysanthemum, an ornamental genus with considerable medicinal value: A comprehensive review Hadizadeh H, Samiei L, Shakeri A
Review Article Anti-Inflammatory Anticancer Antimicrobial
The method involved in this research aimed at studying the genus Chrysanthemum through a decade-long review (2010-2020) of scientific evidence, focusing on its therapeutic potential, phytochemistry, and pharmacological activities. Various phytochemical compounds including flavonoids, terpenoids, polysaccharides, and unsaturated fatty acids, which are present in the genus Chrysanthemum, were identified. In addition, the taxonomy, distribution, horticultural, and traditional uses of the genus were also studied.
The results demonstrated that Chrysanthemum species show numerous potential medicinal benefits, ranging from antioxidant to antimicrobial, anti-inflammatory, anticancer, anti-allergic, anti-obesity, immune regulation, hepatoprotective and nephroprotective activities. The research also underlined the opportunity of medicinal exploitation of the genus Chrysanthemum, given the extreme popularity of these plants and the wide range of phytochemical compounds they contain. The ornamental, medicinal, environmental, and industrial values of these plants further establish them as leading floricultural crops.
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