Insights & Discussion
Consuming dairy products might reduce the risk of developing breast cancer.
The researchers conducted a systematic literature review where they scrutinized various databases for studies published in English up to January 2022. They began with 82 articles, but only 18 met their pre-set inclusion criteria. The studies varied in type - nine were prospective, seven were retrospective, and two were cross-sectional.
The results indicated an inverse relationship between dairy consumption and the risk of developing breast cancer. However, the effect of different types of dairy products and the exact dose-response relationships on breast cancer risk remains unclear. Nevertheless, this review provides a foundation for considering dairy products in preventive strategies to reduce breast cancer occurrence.
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Manuka honey has demonstrated the potential to inhibit the proliferation of human breast cancer cells and stimulate apoptosis in these cells.
2024 Nutrients Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models Márquez-Garbán DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, et al.
Animal Study Breast Cancer Honey
In the experiment, Manuka honey was applied to three different types of cells: MCF-7 human breast cancer cells, MDA-MB-231 breast cancer cells, and non-malignant human mammary epithelial cells. The concentrations applied ranged from 0.3 to 5.0% to observe different effects. In addition to inhibiting cancer cell proliferation, the honey was tested for its ability to cause apoptosis (cell death) among the MCF-7 cells. It was also compared to the effects of tamoxifen, an antiestrogen medication used in breast cancer treatment.
The results showed that Manuka honey was able to significantly inhibit the proliferation of MCF-7 cells, though its effects were less pronounced in the MDA-MB-231 breast cancer cells. The non-malignant cells were not affected. The honey's antitumor activity was comparable to that of tamoxifen. Moreover, Manuka honey stimulated apoptosis in the MCF-7 cells. It was also observed that the honey activated AMPK, which inhibits specific cellular growth signals, and reduced STAT3 levels, a protein often elevated in tumors.
Pomegranate extract could potentially benefit women's reproductive health, enhance fertility, regulate menstrual cycles, support pregnancy, and help treat polycystic ovary syndrome.
2024 Life Therapeutic Potential of Pomegranate Extract for Women’s Reproductive Health and Breast Cancer Jang JY, Kim D, Im E, Kim ND
Breast Cancer PCOS Pomegranate
In establishing the potential benefits of pomegranate extract in women's reproductive health, a wide array of methods was employed. Primarily, these included in vitro studies, animal modeling and certain clinical trials. Analyses of the antioxidant properties of the extract were done to ascertain its effectiveness in reducing oxidative stress and consequently, improving fertility. The influence of pomegranate extract on hormonal imbalances and menstrual regulation was also studied.
Discussions on the results emphasized the potential of pomegranate extract in supporting women's reproductive health. The extract was found beneficial in enhancing fertility, regulating menstruation and supporting pregnancy. Further, it could help in polycystic ovary syndrome therapy by improving insulin sensitivity and reducing oxidative damage. Its rich nutrient composition was appreciated for potentially fostering placental development and fetal growth, thus possibly mitigating the risk of early birth. Apart from reproductive health, some studies pointed towards pomegranate extract's potential anticancer properties, primarily against breast cancer.
Clinical studies related to breast cancer have revealed that honey is effective in increasing blood cell counts, interleukin-3 levels, and quality of life.
2023 Antioxidants Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer Martiniakova M, Kovacova V, Mondockova V, Zemanova N, Babikova M, Biro R, et al.
Clinical Study Breast Cancer Honey Osteoporosis
In relation to breast cancer, in vitro experiments revealed the anti-proliferative and pro-apoptotic impact of honey on breast cancer cells, as well as their increased apoptosis. Animal studies have shown that honey reduces the number, growth rate, volume, and tumor weight. Findings from clinical trials reported its immunomodulatory properties showing that honey is effective in increasing leukocyte and platelet counts, IL-3 levels, and quality of life. In this context, the potential role of honey and its oligosaccharides as prebiotics for specific beneficial bacteria might be examined in future clinical studies.
Preclinical studies related to osteoporosis have reported favorable effects of honey on cortical and trabecular bone microstructure, bone strength, and oxidative stress.
2023 Antioxidants Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer Martiniakova M, Kovacova V, Mondockova V, Zemanova N, Babikova M, Biro R, et al.
Clinical Study Breast Cancer Honey Osteoporosis
Honey is able to protect the bone mainly due to antioxidant and anti-inflammatory properties, primarily through its content of polyphenols, which act on several signaling pathways, resulting in anabolic and antiresorptive effects. From the group of polyphenols, the anti-osteoporotic impact of quercetin, kaempferol, and luteolin was recorded. In addition, vitamin D3 and its hydroxyderivatives with antioxidant properties were also detected in honey. Vitamin D3 supplementation was found to have protective effects on the inhibition of bone loss and BMD in both experimental animals and postmenopausal women.
Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.
2023 Journal of the Science of Food and Agriculture Carrot and carotene and multiple health outcomes: an umbrella review of the evidence Yi X, Li J, Liao D, Peng G, Zheng X, Xu H, et al.
Review Article Alzheimer's Disease Anticancer Breast Cancer
An umbrella review methodology was adopted to identify connections between carrot and carotene intake and various health outcomes. We turned to databases such as Web of Science, PubMed, and Embase to find the needed data. The analysis included the collected evidence from both interventional and observational studies that focused on carrots, carotene, and any related health impact. To estimate the summary effect size for each correlation, both random and fixed effects models were employed.
The study reviewed a total of 1329 studies and utilized the data from 30 meta-analyses with 26 health outcomes that fit the eligibility requirements. These featured outcomes related to various types of cancer, fractures, age-related cataract, sunburn, and Alzheimer's disease. The associations were analyzed between the health outcomes and the intake of carrots, intake of carotene, and serum carotene levels.
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