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Consumption of green tea enriched with a citrus polyphenol, α-glucosyl hesperidin, can prevent weight gain and reduce body mass index, especially in individuals under 50 years.
The research involved a randomized, placebo-controlled, double-blinded, and parallel-group-designed clinical trial. Sixty healthy Japanese men and women aged between 30 and 75 were included in the study. They were instructed to consume a blend of green tea and α-glucosyl hesperidin (GT-gH). Each dosage contained 178 mg α-glucosyl hesperidin and 146 mg of an active ingredient of green tea, called EGCG. This protocol was followed for 12 weeks. Participants underwent physical, hematological, blood biochemical, and urine examinations to ensure safety.
Discussion of findings showed that the GT-gH mixture played a significant role in weight management. By the end of 12 weeks, participants who consumed the GT-gH mix showed prevention in weight gain and a reduction in body mass index when compared to the control group. The anti-obesity effect was particularly observable in individuals aged below 50. These participants experienced lower levels of triglyceride, body fat percentage, and visceral fat levels, alongside a decrease in body weight, BMI, and blood LDL/HDL ratios.
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Green tea helps alleviate symptoms in multiple benign gynecological disorders, primarily due to a compound called Epigallocatechin-3-gallate.
2023 Nutrients Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage? Hazimeh D, Massoud G, Parish M, Singh B, Segars J, Islam MS
Review Article EGCG Green Tea Period Pain
The paper reviews the role of the compound Epigallocatechin-3-gallate found in green tea, and its effects on various benign gynecological conditions. The compound is noted for its antioxidant and prooxidant qualities, allowing it to interact with multiple cellular pathways that are crucial for disease pathogenesis. The studied conditions include uterine fibroids, endometriosis, dysmenorrhea, adenomyosis, menopause, and polycystic ovary syndrome. The research accounts for the specific mechanisms through which the compound might affect each condition, such as anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms.
The results suggest that green tea consumption can lead to improved symptom management in these disorders. It was found to lessen the intensity of symptoms associated with uterine fibroids and endometriosis, by invoking anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms. It also helped manage pain linked with dysmenorrhea and adenomyosis through reducing uterine contractility and widely felt pain. Additionally, it showed efficacy in weight and osteoporosis control during menopause, and showed potential benefits in managing polycystic ovary syndrome. However, claims regarding its influence on fertility were deemed controversial.
Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency.
2023 Nutrients Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women Siblini H, Al-Hendy A, Segars J, González F, Taylor HS, Singh B, et al.
Cohort Study EGCG Green Tea Uterine Fibroids
The study involved the pre-testing of a green tea substance known as Epigallocatechin gallate (EGCG) on a cohort of premenopausal women, aged 18 to 40, with and without uterine fibroids, in order to evaluate its safety. The subjects were randomized into three groups, each receiving different treatments. One group took just a daily dose of 800 mg of EGCG, one group combined this EGCG dose with 100 mg of Clomiphene citrate for five days, and the third group combined it with 5 mg of Letrozole for the same period.
The results showed that none of the subjects displayed signs of drug-induced liver injury, and all had normal serum folate levels. Hence, the findings suggest that the daily intake of 800mg of EGCG, whether consumed alone or in combination with Clomiphene citrate or Letrozole for five days, is well-tolerated and not related to any liver toxicity or folate deficiency in women of reproductive age.
The combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.
2023 Journal of Personalized Medicine The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report Grandi G, Botticelli L, Fraia PD, Babalini C, Masini M, Unfer V
Case Report Cervical Cancer Cervical Dysplasia Cervical Lesions
The methodology used in this research centred around treating a 39-year-old patient who had a history of HPV, cervix lesions, and multiple failed surgical attempts to treat the condition. The treatment plan applied was unique, utilizing a blend of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid, administered over an eight week period.
The results showed promising effects, with the patient's histological and cytological analyses revealing only a chronic cervicitis instead of any malignant lesions or cellular dysplasia. Therefore, the necessity for invasive total hysterectomy was minimized, demonstrating the potential for the selected treatment plan to manage precancerous lesions of the uterine cervix.
Green tea extract, specifically epigallocatechin gallate, can inhibit tumor growth and enhance the quality of life in women suffering from uterine fibroids.
2022 International Journal of Health Sciences The use of green tea in the treatment of symptomatic uterine fibroids Badawy A, Shady NW, Maklad SMA, Ait-Allah AS
Randomised Controlled Trial EGCG Green Tea Uterine Fibroids
A total of 75 reproductive-age women with symptomatic uterine fibroids were included in a prospective, randomized control trial. The selection of participants for either group, those receiving 900 mg of green tea extract or those receiving symptomatic treatment, was done via a random, blind method using sealed envelopes. This trial took place over a span of 4 months and the overall study lasted around 3 years.
The results of the study showcased the potency of green tea extract, particularly EGCG, with special regard to its anticancer properties. These manifested as anti-inflammatory, antiproliferative, and antioxidant effects. It was found that the administration of EGCG managed to influence tumor growth pathways, indicating its efficacy in dealing with uterine fibroids. Moreover, another significant progression was observed in the quality of life for the women partaking in this trial. It was confirmed that the use of EGCG could bring about an overall improvement in the living conditions of these women, contributing towards a better, healthier life amidst the struggle with their condition.
Green tea supplementation can significantly reduce body weight in women with polycystic ovary syndrome, hence potentially beneficial in its clinical management.
2022 Nutrition Research Green tea promotes weight loss in women with polycystic ovary syndrome: Systematic review and meta-analysis Colonetti L, Grande AJ, Toreti IR, Ceretta LB, da Rosa MI, Colonetti T
Meta-Analysis Body Weight Green Tea Obesity
The research carried out was a systematic review of randomized controlled trials that focused on women with polycystic ovary syndrome, examining the effects of green tea supplementation versus a placebo. Relevant studies were sourced from electronic databases such as MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Library, LILACS via BVS, and Web of Science using specific terms related to the illness and green tea. Criteria for the evaluation included effects on body weight, fasting insulin, body mass index, body fat percentage, daily caloric intake, waist and hip circumference, and the waist/hip ratio.
Among the studies considered, there were a total of 169 women, with 85 allocated to the green tea group and 84 to the placebo group. It became apparent that there was a significant reduction in body weight for the group that received green tea supplementation. This leans towards the potential of green tea to be beneficial in the management of this syndrome.
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