Insights & Discussion
Green tea therapy can significantly improve rheumatoid arthritis symptoms, correlating with changes in specific circulating serum molecules, miR-125b and miR-146a.
In this study, 100 female patients suffering from rheumatoid arthritis and 50 healthy female subjects were examined. Patients with rheumatoid arthritis underwent green tea therapy, where they consumed 5 cups of green tea daily, delivering a total of 1230 mg of catechins, over a span of 24 weeks. During this time, researchers used real-time PCR analysis to measure the levels of miR-146a and miR-125 b in the patients' peripheral blood mononuclear cells. These cells were isolated from the subjects at three distinct stages: the starting point (baseline), after 12 weeks, and finally after 24 weeks of the treatment.
The observations revealed a notable increase in the level of circulating miR-125 b and decrease in miR-146 expression, and these shifts were seen to correspond positively with measures of disease activity and pain intensity in the patients after 24 weeks of the green tea therapy. Also of note was that the levels of miR-146a and miR-125b could accurately predict the clinical response to green tea therapy in 65% of the rheumatoid arthritis patients. Discrepancies in miR-146a and miR-125b levels following green tea therapy suggests that they may be attributed to the joint protective, antioxidant, and anti-inflammatory effects of green tea. It was therefore proposed that both miR-146a and miR-125b could potentially serve as diagnostic, therapeutic, and predictive biomarkers in green tea therapy and may even have valuable application in related non-drug rheumatoid arthritis therapy.
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Long-term consumption of green tea can potentially lessen the risk of depression in postmenopausal women by decreasing inflammation and boosting estradiol levels.
2023 Nutrients Long-Term Consumption of Green Tea Can Reduce the Degree of Depression in Postmenopausal Women by Increasing Estradiol Wan Z, Qin X, Tian Y, Ouyang F, Wang G, Wan Q
Cohort Study Anti-Inflammatory Depression Green Tea
In the study, researchers performed an analysis on a tea-producing village, incorporating 386 postmenopausal women in the investigation, who participated either as green tea consumers or non-drinkers (control group). The level of estradiol, inflammation markers, sleep quality, and depression symptoms were measured to uncover any correlations.
The results reflected significant disparities between the tea-drinking and control groups in terms of depression and insomnia levels, BMI, inflammation levels, and estradiol quantities. By appraising these outcomes, it was found that green tea intake could quell the likelihood of depression via its impact on sleep, inflammation, and estradiol levels. The risk of depression was consequently seen as reduced among postmenopausal women engaging in regular consumption of green tea.
Bananas and plantains contain compounds with anti-inflammatory, anti-apoptotic, and antioxidative properties that hold promise for potentially reversing neurological disorders.
2022 Foods Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules Oyeyinka BO, Afolayan AJ
Anti-Apoptotic Anti-Inflammatory Antioxidant
The methodology of the study revolved around scrutinizing the bioactive properties found in bananas and plantains. Researchers pinpointed various neuroprotective mechanisms within commonly consumed fruits, specifically bananas and plantains. The study examined protein expression regulation and targeted specific gene pathways, including nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. In their investigations, they also considered the underutilized peel components of these fruits.
The results suggest that the multitude of bioactive compounds found in both the pulp and peels of bananas and plantains perform a variety of beneficial neuroprotective activities. These range from acting as antioxidants, preventing cell death (anti-apoptotic), and reducing inflammation (anti-inflammatory), to directly influencing the functionality of the nervous system (neuromodulatory). This discovery implicates plant-based foods, specifically bananas and plantains, as potentially significant substances in combating, halting, or mitigating the pathological mechanisms underlying neurodegenerative disorders.
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
2022 Pharmacological Research - Modern Chinese Medicine Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Ai Ye Anti-Inflammatory Antioxidant
The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19.
Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.
Cherries and blueberries, rich in phenolic compounds, can be effectively used in pharmaceutical products, smart foods, functional beverages, and nutraceuticals to prevent or treat diseases.
2022 Molecules Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties Gonçalves AC, Nunes AR, Flores-Félix JD, Alves G, Silva LR
Review Article Anti-Diabetic Anti-Inflammatory Antioxidant
The research primarily studied the health-promoting potential of cherries and blueberries, given their high nutritional density and substantial phenolic compounds. The focus was on their ability to counteract oxidative stress markers and suppress pro-inflammatory responses, which are significant factors in chronic diseases such as diabetes. The researchers analyzed these fruits for their potential incorporation into various products such as pharmaceutical preparations, smart foods, functional beverages, and nutraceuticals.
In the discussion of the results, it was emphasized how cherries and blueberries exhibit significant biological potential. They were not only seen as effective in combatting oxidative stress and inflammation but also as potential immune boosters. The conclusions underscored the fruits' potential role as functional foods and their relevance to the burgeoning popularity of functional beverages, hinting at their promise for inclusion in a variety of health-related products.
Walnut seed skin extract demonstrates potential hepato-renal protective effects, inhibiting inflammatory responses, oxidative stress and apoptosis, in kidney-damaged Sprague-Dawley rats.
2022 Cytokine The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia/reperfusion damage Askin S, Askin H, Dursun E, Palabiyik E, Uguz H, Cakmak , et al.
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In the methodology, Sprague-Dawley rats in acute kidney injury state were divided into three groups: a healthy control, a group induced with renal ischemia/reperfusion (IR), and another group induced with renal IR and treated with walnut seed skin (WSS) extract. Blood, liver and kidney tissues were collected for serum evaluations of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, urea, and creatinine. Histopathological studies were performed on liver and kidney tissues, and gene markers related to anti-oxidant, anti-inflammatory, and apoptotic effects were measured.
The results showed an improvement in deteriorated serum parameters in rats with renal ischemia pre-treated with WSS extract. Histopathological analysis revealed a protective effect of WSS on kidney and liver tissues. Though gene expression studies yielded diverse results for liver and kidney tissues, the consensus was that WSS had a pronounced protective impact on the liver. It was inferred that WSS's healing potential in renal and hepatic tissues seems to work via inhibiting inflammatory response, oxidative stress, and apoptosis.
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