Insights & Discussion
Honey intake has observed beneficial effects on various health aspects like cardiovascular, metabolic risk factors, and wound healing, primarily replacing other sweeteners.
In this comprehensive review study, the researchers went beyond just looking at one or two aspects of health; instead, they embarked on an ambitious task of reviewing forty-eight clinical trials that were published between 1985 and 2022, involving a total of 3655 subjects. The researchers aimed to critically analyze the effect of honey on multiple health indices, including, but not limited to, cardiovascular and metabolic risk factors, glucose tolerance, mucositis inflicted by chemo-radiotherapy, cough in children, and wound healing.
The evaluation and analysis of the data involved a thorough examination of the results of each of the clinical trials, consideration of several potential variables, and detailed cross-study comparisons. This broad and deep investigation allowed the researchers to draw correlations and pinpoint the beneficial influences of honey, considered a nutritious and natural food.
The results from these clinical trials saw more beneficial effects on health from honey intake when compared to neutral or negative outcomes. It was most notably effective, particularly when used as a substitute for other sweeteners. The review also pointed out the potential use of honey as a safe adjuvant to be used in combination with drugs for specific illnesses. Confidently stating that honey has clear benefits in the clinical trials analyzed, the researchers fostered a promising narrative for the further exploration and acceptance of honey as a health booster.
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Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases.
2023 Frontiers in Nutrition Eating more sardines instead of fish oil supplementation: Beyond omega-3 polyunsaturated fatty acids, a matrix of nutrients with cardiovascular benefits Santos HO, May TL, Bueno AA
Review Article Cardiovascular Disease Cholesterol High Blood Pressure
The abstract primarily acknowledges the importance of Omega-3 polyunsaturated fatty acids with respect to managing diseases related to heart health and metabolism, for instance, type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. However, these fatty acids are not the sole beneficial component of sardines. Minerals including but not limited to calcium, potassium, and magnesium as well as substances like taurine and arginine found in sardines have a significant role in controlling mild inflammation and oxidative stress which are usually present in cardiovascular diseases and hemodynamic dysfunction.
The results discussed in the abstract suggest a positive correlation between consumption of sardines and potential cardiometabolic benefits. By considering the dose-response relationship effects, a pragmatic approach towards consumption of nutrients was suggested. The intake of sardines was seen not only as a means of Omega-3 supplementation but also as a comprehensive approach to enhancing cardiovascular health. The abstract concludes with an emphasis on the many beneficial nutrients found in sardines besides Omega-3, underlining the need to shift the focus from synthetic supplementation to natural dietary improvement.
Honey accelerates the healing of diabetic foot ulcers, reduces wound size, and lowers the rates of amputation or hospitalisation, making it a cost-effective and safe treatment.
2023 Applied Sciences Honey Therapy in Diabetic Foot Ulcers: A Promising Strategy for Effective Wound Healing Bezerra A, Fonseca H, Rodrigues F, Delerue-Matos C, Gouvinhas I, Garcia J
Review Article Diabetic Foot Ulcer Honey Wound Healing
The methodology of the review incorporated studies exploring the effects of honey on wound healing, emphasizing its impact on diabetic foot ulcers (DFUs). Different types of honey and their potential influence on treatment efficacy were considered. The review also scrutinised the mechanisms by which honey promotes wound healing and how honey dressings are utilized in the management of diabetic wounds. Nonetheless, it was noted that few of the studies provided comprehensive data regarding the specific characteristics of the employed honey, affecting the comparison across honey types.
The discussion of the results found in most clinical studies indicated that DFUs treated with honey resulted in rapid wound healing, substantial wound contraction, and decreased rates of amputation or hospitalisation. The properties of honey - serving as an effective antibacterial agent against multidrug-resistant bacteria and fostering wound healing through its physical-chemical attributes - were found to be the underlying reasons for these positive outcomes. Furthermore, honey was deemed to be a cost-effective and safe option for managing DFUs.
Honey dressing significantly promotes healing and reduces recovery time in managing diabetic foot ulcers.
2023 Journal of Tissue Viability Use of honey in diabetic foot ulcer: Systematic review and meta-analysis Yildiz Karadeniz E, Kaplan Serin E
Systematic Review Diabetic Foot Ulcer Diabetic Foot Ulcers Honey
For the research methodology, the study used a combination of randomized controlled trials, quasi-experimental, and cross-sectional studies. Only the randomized controlled trials and quasi-experimental studies were chosen for the meta-analysis, while observational studies were subject to a descriptive analysis.
In terms of the results discussion, the meta-analysis indicated that using honey as a dressing for diabetic foot ulcers resulted in a reduction in wound recovery time, pain experienced, duration of hospital stay, and an acceleration in wound granulation. Therefore, it was concluded that honey dressing is an effective intervention for accelerating healing in diabetic foot ulcers.
Cocoa flavanols exhibit health and aging benefits and may act as powerful agents in preventing chronic diseases such as cardiovascular and metabolic disorders, and cancer.
2021 Food and Chemical Toxicology Impact of cocoa flavanols on human health Martin M, Ramos S
Systematic Review Anti-Ageing Cardiovascular Disease Cocoa
This research primarily relies on a comprehensive review of numerous human studies conducted over the past two decades. These studies provided significant data related to the health effects of cocoa intake and its impact on various chronic diseases. The studies encompassed different demographics and health conditions.
Though most studies indicate beneficial effects of cocoa on health and prevention of chronic diseases, the results exhibit some inconsistency. Different studies suggest various mechanisms of action for cocoa, but these potential pathways are still not completely understood. Also, crucial issues like recommending cocoa consumption to healthy subjects or patients, determining the appropriate dosage, or the period of intake remain unresolved. Despite these unclarities, the potential of cocoa use to decrease the risk for certain chronic diseases and improve general health and quality of life is emphasized.
Daily consumption of tart cherry juice may reduce processes involved in accelerated atherogenesis, potentially decreasing the risk of cardiovascular diseases.
2020 Journal of Medicinal Food Effects of Montmorency Tart Cherry Juice Consumption on Cardiometabolic Biomarkers in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Trial Johnson SA, Navaei N, Pourafshar S, Jaime SJ, Akhavan NS, Alvarez-Alvarado S, et al.
Randomised Controlled Trial Atherogenesis Cardioprotective Effects Cardiovascular Disease
In this randomized, single-blind, placebo-controlled, parallel-arm pilot clinical trial, 19 men and women aged between 20 to 60 years who have metabolic syndrome participated. They were assigned to consume either 240ml of tart cherry juice or an isocaloric placebo-control drink twice daily for a period of 12 weeks. Initial evaluations on arterial stiffness (determined through pulse wave velocity), brachial and aortic blood pressures, wave reflection or augmentation index, and blood markers for cardiovascular and metabolic health were established as their baseline values.
Despite observing no significant alterations in hemodynamics, arterial stiffness, or other assessed blood biomarkers, there was a noted decrease in oxidized low-density lipoprotein and soluble vascular cell adhesion molecule-1 levels in the tart cherry juice group compared to the control group at the end of 12 weeks. In addition, there was a trending lower total cholesterol level in the tart cherry group versus the control at the end of the trial. These results suggest that daily tart cherry juice consumption may help decrease processes involved in the rapid progression of atherogenesis.
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