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Ginger supplementation can prevent ethanol-induced reproductive dysfunction by improving hormone levels, reducing oxidative damage, inflammation, and regulating genes involved in testosterone synthesis.
2021 Brazilian Archives of Biology and Technology Ginger (Zingiber officinale Roscoe) Improves Ethanol-Induced Reproductive Dysfunction by Enhancing Steroidogenesis and Inhibiting Oxidative Stress and Inflammation Li N, Xing Y, Sultan AH, Raeeszadeh M, Akbari A, Liu H
Experimental Study Ginger Inflammation Oxidative Stress
The methodology involved twenty-four adult male rats divided into four groups for a 28-day experiment. The researchers administered either ethanol or ginger extract to respective groups and then measured varying physiological factors related to reproductive health such as testosterone levels, antioxidant enzyme activity, concentrations of tumor necrosis factor-alpha, and gonadotropins hormones. In addition, gene expressions related to oxidative damage, inflammation, and testosterone synthesis were also examined.
Animating the discussion of results, it was observed that the administration of ethanol significantly decreased levels of hormones, oxidative markers, and lowered gene expression involved in testosterone synthesis. Conversely, ethanol caused an increase in inflammatory markers and the expression of genes related to inflammation. On the other hand, rats given a ginger supplement positively reversed these effects, showing significant improvements in all factors, thus leading to the conclusion that ginger can prevent reproductive issues induced by ethanol. The results obtained from the histological study further confirmed these findings, reaffirming that ginger could effectively counter ethanol-induced reproductive dysfunction.
Pomegranate juice supplementation notably diminishes inflammation and vascular dysfunction markers in adults, offering potential cardiovascular health benefits.
2020 Complementary Therapies in Medicine The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review Wang P, Zhang Q, Hou H, Liu Z, Wang L, Rasekhmagham R, et al.
Meta-Analysis Endothelial Dysfunction Inflammation Pomegranate
The research used a broad approach, systematically reviewing and performing a meta-analysis of 16 randomised controlled trials including 572 participants, as per the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. Relevant articles and references were found via the PubMed/Medline and SCOPUS databases, with screening carried out up until May 2019. The studies explored the impact of pomegranate juice supplements.
The discussion reveals that pomegranate supplementation conspicuously reduced the levels of certain pro-inflammatory and vascular dysfunction markers. However, the research found no significant reduction in some other markers when compared to a placebo. Despite not all markers recording significant reduction, the overall findings strongly suggest pomegranate supplements as a viable tactic for reducing inflammation in adults, potentially offering cardiovascular health advantages.
Daily consumption of tart cherry juice for 12 weeks showed anti-oxidative and anti-inflammatory properties which may reduce blood pressure and lower LDL cholesterol in older adults.
2019 Nutrients Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults Chai S, Davis K, Zhang Z, Zha L, Kirschner K
Randomised Controlled Trial Cherry High Blood Pressure Inflammation
In the randomized-controlled clinical trial conducted, 37 participants aged between 65 and 80 were given either 480 mL of tart cherry juice or a control drink to consume daily for a span of 12 weeks. Blood biomarkers linked to inflammation and oxidative stress were analyzed both at the start and after the 12 weeks intervention.
Post the intervention period, levels of several inflammation and oxidative stress blood biomarkers in the tart cherry juice group observed notable differences compared to the control group. Particularly, a perceivable elevation in DNA repair activity coupled with a reduced mean c-reactive protein level was seen. Furthermore, a significant group effect was seen in plasma levels of c-reactive protein and malondialdehyde, with a slightly less significant effect observed for oxidized low-density lipoprotein. Post- intervention plasma levels showed a decreasing trend, with c-reactive protein, malondialdehyde, and oxidized low-density lipoprotein falling by 25%, 3%, and 11% respectively compared to the baseline values.