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Ginger, peppermint and caraway oil combination showed strong effectiveness in managing upper gastrointestinal complaints, with melatonin and marine alginate demonstrating moderate evidence.
2022 Nutrients Effectiveness of Nutritional Ingredients on Upper Gastrointestinal Conditions and Symptoms: A Narrative Review Schulz RM, Ahuja NK, Slavin JL
Review Article Alginate Caraway GERD
The methodology consisted of a literature review of the scientific studies pertaining to nutritional ingredients for upper gastrointestinal relief. The selection was based on recurring mentions within the literature and frequent appearance in consumer products. A predefined search for specific nutritional ingredients and terms related to upper GI health was conducted in five databases - Embase, Medline, Derwent drug file, ToXfile, and PubMed. A manual search was also undertaken for each ingredient to ensure comprehensive review.
The studies that gained inclusion encompassed 16 human clinical trials assessing nine different ingredients. The products investigated were divided into categories, including botanicals - with sub-categories of fiber and combinations, and non-botanical extracts. Several products demonstrated good potential, others showed promising but moderate results, while some had limited support from the scientific research.
Peppermint's extensive applications, especially its antimicrobial and antioxidant features, and potential health benefits can significantly increase its market value in various industries.
2020 Journal of Pharmacognosy and Phytochemistry Peppermint a medicinal herb and treasure of health: A review Parv Nayak, Tankesh Kumar, AK Gupta and NU Joshi
Review Article Antimicrobial Antioxidant
The study assembled and examined various research papers concerning the drying methods of peppermint. The focus was on how different drying methods affect the drying time, rate and enhancement of quality in terms of color and physical properties. As peppermint is a highly perishable and seasonal plant, efficient drying is important to extend its shelf life, decrease packaging and transportation costs, and generally ensure its availability all year round.
In the analysis of the results, the health benefits of peppermint were reviewed in depth, highlighting its anti-viral, anti-bacterial, anti-inflammatory, and anti-fungal properties, among others. Other beneficial advantages such as its anti-asthmatic, allopathic, spasmolytic, anti-headache, anti-septic, and radioactive properties were also in the spotlight, implying the enormous potential of peppermint in not just the food and cosmetic industries, but the medical and biotechnological area as well. This suggests that the plant can be leveraged more for wider human prosperity.
A combination of peppermint oil and caraway oil is an effective and safe short-term treatment for functional dyspepsia.
2019 Evidence-Based Complementary and Alternative Medicine A Combination of Peppermint Oil and Caraway Oil for the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis Juanjuan Li, Lin Lv, Jiaqi Zhang, Lin Xu, Enjin Zeng, Zedan Zhang, et al.
Systematic Review Caraway Digestive Health Indigestion
It is the first attempt to generate RCT data of peppermint oil and caraway oil (POCO) for the treatment of functional dyspepsia. In this meta-analysis, we evaluated the efficacy and safety of POCO based on five RCTs with 578 patients. The results demonstrated that POCO can significantly improve global symptoms of FD, with an NNT of 3 when data from four studies were pooled. The positive and significant efficacy in terms of improvement in epigastric pain was also shown between the two studies. Moreover, the available data have found that the safety profile of POCO is similar to placebo.
The strength of our findings is that no significant heterogeneity was detected across the studies. Besides, study designs of the included trials were fairly similar and the duration of treatment was identical. We used rigorous methodology as follows and believe that the results reflect the best available current evidence. Firstly, our literature search was comprehensive including all RCTs regardless of publication type and language. Besides, we adopted the intention-to-treat analysis on all data to enhance the robustness of the results.
Peppermint oil significantly reduces colonic spasm during colonoscopy, but does not affect the adenoma detection rate or cecal intubation time.
2019 The American Journal of Gastroenterology Peppermint Oil Decreases Colonic Spasm Without Significantly Affecting Cecal Intubation Time and Adenoma Detection Rate: A Systematic Review and Meta-Analysis Nehme, Fredy; Al Momani, Laith; Alomari, Mohammad ; Zafar, Yousaf
Systematic Review Irritable Bowel Syndrome Peppermint Oil
The methodology of this research primarily involved a review of randomized controlled trials that compared the use of peppermint oil and a placebo during colonoscopies. The various trials selected for review were identified through comprehensive searches of databases such as Medline, Google Scholar, and Cochrane up until May 2019. The analysis took into account key variables, including the extent of peristalsis inhibition, cecal intubation time, and adenoma detection rates.
In terms of results, there was significant variation in the dosage and administration of the peppermint oil among the 5 trials that qualified for the review. Comparisons were made between a group of 623 subjects who received peppermint oil and a placebo group of 239 individuals. It was found that peppermint oil led to a significant increase in the complete inhibition of colonic peristalsis. However, the cecal intubation times and adenoma detection rates were similar across both the peppermint oil and placebo groups, despite the high level of variation observed.
Peppermint oil capsules may significantly reduce the severity of premenstrual syndrome symptoms in reproductive-age women.
2019 Iranian Red Crescent Medical Journal Effect of Peppermint Oil on Premenstrual Syndrome: A Randomized, Double-Blind Placebo-Controlled Study Agajani Delavar M, Ebrahimi S, Esmaeilzadeh S, Khamse A
Randomised Controlled Trial Peppermint Oil Premenstrual Syndrome
The study was a randomized, double-blind, placebo-controlled trial involving 50 high school students in Babol, Iran who were diagnosed with premenstrual syndrome. Participants were divided into two groups. One group was given Colpermin® capsules, which contained peppermint oil, while the other group was given a placebo. These were taken twice daily from the 15th day of one menstrual period to the first day of the next period across two menstrual cycles. The severity of PMS was evaluated at the first luteal phase of the menstrual cycle and again at the third luteal phase, using a 28-item PMS checklist.
Over two menstrual cycles, participants who took the peppermint oil capsules experienced a more significant decrease in premenstrual syndrome scores compared to those in the placebo group. Thus, peppermint oil has demonstrated its potential as an effective treatment in managing the severity of premenstrual syndrome symptoms in this sample.
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