Insights & Discussion
The combined use of chamomile and saffron with usual medication enhances the efficacy against depression and ensures long term improvement.
This research was a randomized, open, blinded trial with 120 participants split evenly into a test and control group. After consent was obtained, a patient health questionnaire was filled out to determine depression scores. Participants in the test group received herbal tea sachets, containing 20 mg of chamomile and 1 mg of saffron, twice per day for a month in addition to their regular medications. Control group participants only received their standard allopathic medicine. Blood samples were taken both before and after the treatment period.
The test showed significant improvement in depressive symptoms for both groups. However, in the test group, the addition of the herbal teas amplified the effect of the medications. The herbal adjuvant therapy reduced inflammatory markers and tryptophan levels in plasma, which increased the availability of tryptophan in the brain, a key aspect in managing depression. Consequently, the research concluded that inclusion of these herbs enhances the effectiveness of the conventional treatment against depression and provides long term benefits.
Discover Related Insights
Green tea polyphenols can potentially protect against neurodegenerative disorders like Parkinson's Disease through antioxidant, anti-inflammatory, and neuroprotective actions.
2020 Molecules Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review Malar DS, Prasanth MI, Brimson JM, Sharika R, Sivamaruthi BS, Chaiyasut C, et al.
Review Article Anti-Inflammatory Antioxidant Green Tea
The study synthesized existing research on the potential neuroprotective benefits of green tea polyphenols, particularly in Parkinson's disease. The papers highlighted were drawn from numerous sources and focused on the antioxidant, anti-inflammatory, and neuroprotective attributes of these compounds. Green tea's potential protection against free radicals, inflammation, and neuro-damage were considerable points of interest. The analysis also took into account the complex physiological, social, and cultural factors that could influence the effectiveness of green tea polyphenols in human subjects.
Through the evaluation of numerous in vivo studies, researchers came to intriguing conclusions about the overall mechanism of green tea. The studies assessed explored how green tea consumption could mitigate neurodegenerative disorders like Parkinson's. In these analyses, investigators refined their understanding of how green tea and its polyphenols function from a neuroprotective standpoint. This information helps us better understand the advantages of green tea consumption and its potential role in preventing neurodegeneration.
Curcumin, a component of Indian spice turmeric, presents a potential natural treatment for depression, influencing neurotransmitters and protecting against several biological systems compromised in depression.
2012 Journal of Psychopharmacology Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects Lopresti AL, Hood SD, Drummond PD
Review Article Anti-Inflammatory Immunomodulation Neuroprotective
The research methodology involved an extensive review of the varying influences and effects of curcumin on systems implicated in depression. These included neurotransmitter systems like serotonin and dopamine which are critical to mood regulation. The study also explored the effects of curcumin on hypothalamus-pituitary-adrenal disturbances, famously associated with stress response and mood disorders.
In terms of results, curcumin demonstrated promising potential as an antidepressant in animal models of depression. Additionally, it was found to help moderate damage to neurological systems and intestinal permeability, both of which are often compromised in major depressive disorders. It also exhibited properties that could help lower inflammation and protect against oxidative stress and mitochondrial damage. Together, these findings position curcumin as a promising natural treatment for depression.