Insights & Discussion
Consumption of raw milk early in life appears to provide protection against asthma and allergies, regardless of whether children live on farms or in rural, non-farm areas.
Whoever did the research carried out a comprehensive literature review, identifying twelve relevant publications from eight unique studies. Their approach involved a meta-analysis to substantiate the protective effect of raw milk consumption in early life, particularly for ages ranging from less than one year old to five years old. They further analyzed the impacts of raw milk on not only asthma but also other ailments such as wheezing, hay fever, allergic rhinitis, and atopic sensitization. Moreover, evidence was provided about the beneficial effects of raw milk for children, both living on the farms and those in rural sectors but not on farms.
Moreover, in the interpretation of results, it was clearly evident that the consumption of raw milk had an independent effect, separate from other farm exposures. In essence, even children not residing on farms theoretically can still gain from the benefits of raw milk consumption. However, they express a strong sense of caution, advocating against the consumption of raw milk due to the possibility of life-threatening infections. Furthermore, the distinction between raw farm milk and industrially processed milk was underlined to highlight differences in cellular components, fat fraction, and heating degrees. Preliminary findings link these characteristics and attributes of raw milk to heat-labile molecules and components found in its fat fraction.
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Korean pear extracts appear to alleviate air pollution-related respiratory hypersensitivity by modulating beneficial gut microflora and suppressing pro-inflammatory cytokines.
2023 Journal of Medicinal Food Effects of Pear Extracts on Microbiome and Immunocytokines to Alleviate Air Pollution-Related Respiratory Hypersensitivity Yang M, Lee U, Cho HR, Lee KB, Shin YJ, Bae MJ, et al.
Air Pollution Gut Microbiota Pear
In the preclinical and randomized double-blind clinical studies, mild-asthma subjects living in Seoul, Korea were divided into two groups: one receiving a daily treatment of pear extracts for four weeks, and a placebo group. The pear extract was tested for its ability to mitigate respiratory hypersensitivity connected to air pollution. The treatment's effects were evaluated based on the toxicokinetic study of exposure biomarkers for airborne polyaromatic hydrocarbons and levels of pro-inflammatory cytokines in human subjects.
In terms of results, it was found that those individuals receiving daily pear extract exhibited decreased levels of exposure biomarkers related to airborne polyaromatic hydrocarbons. Furthermore, the pear extract treatment was associated with a significant increase in populations of fiber-degrading bacteria that boost beneficial gut microflora crucial for immune defense. Additionally, the extracts significantly suppressed the production of various pro-inflammatory cytokines, as per the preclinical tests conducted on asthma-induced mice. Overall, these outcomes suggest a beneficial role of Korean pear extracts in mitigating air pollution-related respiratory hypersensitivity.
HuoXiang ZhengQi (HQXXD) may be a safe and effective treatment for Chronic Cough Variant Asthma (CVA), improving clinical efficacy and airway responsiveness while reducing recurrence rates.
2022 Evidence-Based Complementary and Alternative Medicine The Effectiveness and Safety of Huangqi Xixin Decoction for Cough Variant Asthma: A Systematic Review and Meta-Analysis Wang C, Xia Q, Hu B, Jiang W, Zhang H
Systematic Review Cough Huang Qi Huangqi Xixin decoction
HuoXiang ZhengQi (HQXXD) for Chronic Cough Variant Asthma (CVA) was systematically evaluated. The HQXXD group showed significantly higher total effective rates of clinical efficacy and airway responsiveness compared to the control group, while the recurrence rate was lower. Adverse reactions were not reported in HQXXD treatment, indicating its safety for CVA patients.
Asthma severity can be notably reduced by Xi Xin essential oil, which decreases inflammation, immunoglobulins, and fibrotic mediators, while also alleviating airway obstruction.
2022 Pharmaceutics Exploring the Potential Effects and Mechanisms of Asarum sieboldii Radix Essential Oil for Treatment of Asthma Han JM, Kim MH, Choi LY, Kim G, Yang WM
Network Pharmacology Xi Xin
AEO was administered via a nebulizer for three weeks ahead of exposing mice to ovalbumin (OVA), a protein commonly used to provoke an allergic reaction, and particulate matter (PM), common air pollutants. Co-treatment of AEO, OVA, and PM was carried out for four weeks. Additionally, A549 lung epithelial cells were exposed to PM to study the influence of AEO on lung-fibrosis-related factors.
In our study, we found that AEO notably inhibited goblet cell accumulation, which led to a decrease in epithelial thickness. Collagen deposition in lung tissues, a common marker of airway remodeling, was significantly inhibited by AEO in asthmatic mice exposed to OVA and PM. AEO also lessened the influx of inflammatory cells into the bronchoalveolar lavage fluid, an indicator of respiratory inflammation. Similarly, the increases in serum IgE and IgG, immunoglobulins associated with allergic reactions, and cytokines in lung tissues were reduced by AEO. Moreover, AEO successfully managed the expression of key fibrotic mediators, particularly POSTN and TGF-β. All these indicators point to AEO's potential as a promising therapeutic treatment to alleviate asthma symptoms.
The type of dairy production system can influence the overall and specific levels of microRNAs, potentially affecting the functional potential of dairy products.
2022 Veterinary Sciences Differences in the microRNAs Levels of Raw Milk from Dairy Cattle Raised under Extensive or Intensive Production Systems Abou el qassim L, Alonso J, Zhao K, Le Guillou S, Diez J, Vicente F, et al.
Experimental Study Raw Milk
The research initially observed levels of microRNAs present in fat and cellular components from tank milk collected from farms using both intensive and extensive dairy production models. They commenced by sequencing microRNAs from three different milk samples from each production method. These selected microRNAs, which showed notable variance in both the fat and cellular content between the two production systems, were then further validated by conducting quantitative PCR on tank milk samples procured from an additional twenty different commercial farms.
The team discovered that the differences in the amounts of microRNAs were most significant in the fat portions of the milk. Here, they found that both the overall levels of microRNAs and the levels of specific types were considerably higher in milk from the intensive production system when compared to the extensive system. They also undertook a pathway analysis of the bovine mRNA targets for these specific microRNAs. While the precise reasons for these discrepancies in microRNA levels are yet to be determined, the research strongly indicated that the choice of production system could have a direct impact on both the microRNA content and the potential functionality of dairy and other agri-food products.
Honey, traditionally a food item, exhibits therapeutic properties—anti-microbial, anti-inflammatory, anti-cancer, and wound healing—showing promise in managing and preventing allergic diseases, as supported by scientific evidence and clinical studies.
2021 Frontiers in Pharmacology The Potential use of Honey as a Remedy for Allergic Diseases: A Mini Review Aw Yong PY, Islam F, Harith HH, Israf DA, Tan JW, Tham CL
Review Article Allergy Eczema Honey
This mini review explores honey's transition from a conventional food to a potential treatment for allergic diseases. Emphasis is placed on its diverse therapeutic properties, particularly its ability to alleviate pathological conditions and regulate inflammatory cell recruitment in cellular and animal models.
Scientific evidence and clinical studies suggest that honey holds potential in relieving allergic symptoms, offering a promising treatment or preventive approach for allergic diseases such as anaphylaxis, asthma, and atopic dermatitis. The review provides valuable insights for considering honey in clinical settings for allergic disease management.
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